Advances in Molecular Therapeutics for HIV Co-Infections
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 602
Special Issue Editors
Interests: mycobacterial diseases; tuberculosis; host immune responses; pathogenesis
Special Issues, Collections and Topics in MDPI journals
Interests: vaccines; innate immunity; macrophages; neutrophils; inflammation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Ever since human immunodeficiency virus (HIV) was first discovered in 1981 more than 40 million people have died due to acquired immunodeficiency syndrome (AIDS). Currently 38 million people are living with HIV infection. HIV compromises the body’s immune system, increasing the likelihood of contracting opportunistic infections.
AIDS patients often suffer or die due to tuberculosis (TB). HIV and TB are considered a syndemic, defined as “the convergence of two or more diseases that act synergistically to magnify the burden of disease”. Today, TB remains the leading infectious cause of death in people with HIV, who are 15–22 times more likely to contract TB than people without. Importantly, HIV has been linked to several outbreaks of TB globally, especially in sub-Saharan Africa.
Much is known about the syndemic relationship of HIV and TB, yet the specifics and mechanisms behind how these two diseases interact have not been entirely addressed. This review will explore how Mtb worsens HIV infection. The objective of this review is to provide an insight into the interaction between Mtb and HIV to help overcome the difficulties in co-treatment of HIV and TB.
The special issue therefore invites submissions on:
- Strategies to maintain the immune system in those with HIV infection tp prevent M. tb co-infection.
- Adjunctive therapies for HIV and M. tb co-infection.
- Novel therapies to prevent HIV infection and M. tb co-infection in HIV-infected individuals.
- Treatment that will maintain undetectable viral load to prevent co-infections with tuberculous and non-tuberculous mycobacterial infections.
- Efforts to prevent HIV from developing resistance to ART.
- Recent developments in understanding the host immune responses against HIV and M. tb/M. avium co-infections.
- Current breakthroughs in the understanding of M. tb pathogenesis in the context of HIV infection.
Prof. Dr. Vishwanath Venketaraman
Dr. Selvakumar Subbian
Guest Editors
Manuscript Submission Information
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Keywords
- HIV co-infections
- molecular therapeutics
- Mtb
- ART
- immune responses
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