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Advances in Diabetic Ischemic Heart Failure

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 481

Special Issue Editor


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Guest Editor
1. Cardiology Clinic, University Clinical Center of Serbia, Belgrade, Serbia
2. Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Interests: coronary heart disease; hypertrophic cardiomyopathy; myocardial ischemia; cardiomyopathy

Special Issue Information

Dear Colleagues,

In patients with diabetes mellitus, rapid progression of atherosclerosis can lead to spectrum of cardiovascular diseases including chronic and acute forms of coronary artery disease, as well as ischemic cardiomyopathy and heart failure. Over the last 5–10 years we have witnessed on one of the major advances in the field of cardiology regarding new treatment modalities in patients with heart failure. In fact, application of new glucose-lowering drugs—sodium/glucose-co-transporter-2 (SGLT2) inhibitors and glucagon-like peptuide-1 (GLP1) receptor agonists—has further promoted interest in the management of patients with diabetes, ischemic heart disease and heart failure. Determining the best molecular diagnostic, therapeutic and revascularization strategy with diabetes, ischemic heart disease and heart failure remains one of the most challenging issues in current cardiology treatment.

In this special issue, we shall discuss different aspects of ischemic cardiomyopathy with diabetes starting with pathophysiological mechanism for the progression of the disease to heart failure, followed by contemporary diagnostic and therapeutic modalities, up to revascularization options and strategy.

Prof. Dr. Branko Beleslin
Guest Editor

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Keywords

  • diabetes
  • ischemic cardiomyopathy
  • pathophysiology
  • diagnostics
  • therapy

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Published Papers (1 paper)

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Review

19 pages, 706 KiB  
Review
Myocardial Revascularization in Patients with Diabetes and Heart Failure—A Narrative Review
by Stefan Zivkovic, Aleksandar Mandic, Kosta Krupnikovic, Aleksa Obradovic, Vojko Misevic, Mihajlo Farkic, Ivan Ilic, Milorad Tesic, Srdjan Aleksandric, Stefan Juricic, Branko Beleslin and Milan Dobric
Int. J. Mol. Sci. 2025, 26(7), 3398; https://doi.org/10.3390/ijms26073398 - 5 Apr 2025
Viewed by 337
Abstract
Heart failure and diabetes mellitus are major contributors to global morbidity and mortality, with their prevalence continuously rising, primarily due to aging populations and improvements in healthcare. These conditions often coexist or develop sequentially, leading to complex interactions that significantly influence the progression [...] Read more.
Heart failure and diabetes mellitus are major contributors to global morbidity and mortality, with their prevalence continuously rising, primarily due to aging populations and improvements in healthcare. These conditions often coexist or develop sequentially, leading to complex interactions that significantly influence the progression and management of both diseases. Furthermore, heart failure and diabetes are commonly associated with coronary artery disease, which presents a unique challenge in clinical management, particularly in the context of myocardial revascularization. The presence of diabetes exacerbates atherosclerotic progression and impairs endothelial function, while heart failure complicates the perfusion and recovery of myocardial tissue post-intervention. This narrative review delves into the underlying mechanisms contributing to revascularization failure in patients with heart failure and diabetes, emphasizing the importance of understanding these interactions for optimal treatment. The review also summarizes key findings from randomized controlled trials, examining evidence both in the general population and in specific subgroups, including the elderly and patients with left main coronary artery disease, chronic kidney disease, peripheral artery disease, and chronic obstructive pulmonary disease. Understanding these complexities is critical for improving patient outcomes. Full article
(This article belongs to the Special Issue Advances in Diabetic Ischemic Heart Failure)
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