Molecular Mechanism and Therapeutic Approaches of Breast Cancer, Metastatic Breast Cancer, 3rd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 1027
Special Issue Editor
2. Department of Bio-Healthcare, Hwasung Medi-Science University, Hwaseong-si 18274, Republic of Korea
Interests: molecular mechanism; tumor microenvironment; epithelial-to-mesenchymal transition (EMT); post-translational modification (PTM); autophagy; potential therapeutic approaches; preclinical mouse models for cancers; breast cancer; liver cancer; lung cancer; pancreatic cancer; cancer progression and metastasis
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Special Issue Information
Dear Colleagues,
Breast cancers are heterogeneous and have a multistep progression at molecular and morphologic levels during tumor development. Metastatic breast cancer is a cancer that originated in the breast, dispersed into the lymph nodes or several other sites, such as the bone, liver, lung, or brain, and acquired genetic and epigenetic alterations in cancer cells. The molecular mechanisms of the epithelial-to-mesenchymal transition (EMT) are therapeutic targets in metastatic breast cancer. Metastasis is a multistage process that is involved in various epigenetic and post-translational modifications (PTMs) during breast cancer progression and metastasis. The remodeling between the tumor microenvironment and the extracellular matrix (ECM) is also essential for metastasis. Various elements of the breast tumor microenvironment enhance metastatic progression.
This Special Issue, “Molecular Mechanism and Therapeutic Approaches of Breast Cancer, Metastatic Breast Cancer, 3rd Edition”, aims to provide a platform for obtaining new, deeper insights into the molecular mechanisms and potential therapeutic approaches in cancer. Authors are invited to submit original research and topical review articles on these topics.
Dr. Mi Kyung Park
Guest Editor
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Keywords
- breast cancer
- metastatic breast cancer
- epithelial-to-mesenchymal transition (EMT)
- epigenetic and post-translational modifications (PTM)
- tumor microenvironment
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