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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Strategies for Enzyme-Based Biosensors

edited by

Roxana Apetrei

submission deadline 31 Dec 2026 | Viewed by 74 | Submission Open

Keywords: molecular recognition; biocatalysis; biological receptors; nanozymes; molecularly imprinted polymers; transduction interfaces

(This special issue belongs to the Section Macromolecules)

Molecular Insights into Sustainable Food and Packaging Systems

edited by

Kingwascharapong Passakorn

submission deadline 1 Jan 2027 | Viewed by 112 | Submission Open

Keywords: molecular food science and molecular interactions; structure–function relationships of food biomolecules; bioactive compounds and functional ingredients; food quality, stability, and functionality; alternative proteins; sustainable processing and circular economy; by-product valorization; biodegradable and active packaging; biomaterials for food and packaging applications; advanced analytical and characterization techniques

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Uncovering the Advantages of Natural Medicines in Treating and Preventing Diseases

edited by

Xingkang Wu

submission deadline 20 Jan 2027 | Viewed by 149 | Submission Open

Keywords: natural medicine; natural product; natural product derivatives; traditional medicine; extract; therapeutic efficacy; toxicological effects; multi-target, multi-pathway

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Novel Insights into Active Substances and Extracts

edited by Diamanto Lazari and

Charikleia Paloukopoulou

submission deadline 20 Jan 2027 | Viewed by 118 | Submission Open

Keywords: bioactive compounds; natural products; synthetic molecules; functional materials; molecular mechanisms; cell signaling; oxidative stress; structure–activity relationships; nutraceuticals; molecular pharmacology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advances in Anticancer Agents: Discovery, Development, and Clinical Applications

edited by

Nicoletta Cordani

submission deadline 20 Jan 2027 | Viewed by 101 | Submission Open

Keywords: anticancer agents; targeted therapy; immunotherapy; drug discovery; precision oncology; biomarkers; drug resistance; combination therapy; translational research; clinical applications

(This special issue belongs to the Section Molecular Pharmacology)

Melanoma: Advances in Biology and Treatment

edited by

Joanne Tobacman

submission deadline 20 Jan 2027 | Viewed by 84 | Submission Open

Keywords: chondroitin sulfate; proteoglycans; chondroitin sulfatases; sulfotransferases; microenvironment; checkpoint inhibitor combinations

(This special issue belongs to the Section Molecular Biology)

Nanodelivery Systems in Health and Disease: Molecular Design and Biomedical Applications

edited by

Chi Lin

submission deadline 25 Jan 2027 | Viewed by 119 | Submission Open

Keywords: nanodelivery systems; molecular design; targeted drug delivery; stimuli-responsive nanocarriers; supramolecular assembly; bioactive molecules; nucleic acid delivery; biomedical applications; nutraceutical delivery

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Basis of Vector–Host–Pathogen Interactions

edited by

Van Lun Low

submission deadline 28 Jan 2027 | Viewed by 91 | Submission Open

Keywords: vector–host–pathogen interactions; vector-borne diseases; vector competence; host immune responses; pathogen transmission; molecular mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Cancer-Driving Molecules: From Molecular Mechanisms to Novel Therapeutics

edited by

Georgios Pantouris

submission deadline 29 Jan 2027 | 8 articles | Viewed by 12576 | Submission Open

Keywords: cancer; mechanism of action; tumor microenvironment; immune system; DNA/RNA/protein; small-molecule probes; activation/inhibition; biological activity

(This special issue belongs to the Section Molecular Oncology)

Emerging Trends of Biotechnology in Bioremediation and Biodegradation

edited by

Marta Alejandra Polti

submission deadline 29 Jan 2027 | 1 articles | Viewed by 3018 | Submission Open

Keywords: emerging technologies; biological treatment; environmental sustainability; innovative methodologies; ecosystem restoration

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Hypertension

edited by Pedro A. José

submission deadline 29 Jan 2027 | 2 articles | Viewed by 2425 | Submission Open

Keywords: salt sensitivity; inverse salt sensitivity; epigenetics; genetics; organ-to-organ communication

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Plant Nutrient Uptake and Signaling Networks

edited by

Tarek Alshaal

submission deadline 29 Jan 2027 | 1 articles | Viewed by 822 | Submission Open

Keywords: rhizosphere interactions; ion homeostasis; transporter regulation; signal transduction; transcriptional control; nutrient use efficiency; root architecture; plant–microbe symbiosis; abiotic stress adaptation; omics integration

(This special issue belongs to the Section Molecular Plant Sciences)

Plant Genome Editing: Recent Advances and Future Perspectives

edited by

Hakim Manghwar

submission deadline 29 Jan 2027 | 1 articles | Viewed by 614 | Submission Open

Keywords: gene knockout; gene knock-in; gene knockdown; base editing; transcription activation; prime editing; off-target analysis; new CRISPR variants; high-throughput genome editing system

(This special issue belongs to the Section Molecular Plant Sciences)

Mitochondrial Signaling Pathways in Inflammation and Diseases

edited by

Francesca Oppedisano

and

Cristina Algieri

submission deadline 29 Jan 2027 | Viewed by 508 | Submission Open

Keywords: mitochondria; cell metabolism; inflammatory mitochondrial signalling; metabolic pathways; mitochondrial dysfunction; mtDNA; cGAS-STING pathway; NLRP3 inflammasome; human pathology

(This special issue belongs to the Section Biochemistry)

Emerging Metabolomics Techniques and Applications

edited by Jun Han

submission deadline 29 Jan 2027 | Viewed by 275 | Submission Open

Keywords: metabolomics; lipidomics; bioinformatics; micro-extraction; chemical derivatization; liquid chromatography-mass spectrometry (LC-MS); matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS); gas chromatography-mass spectrometry (GC-MS); metabolic profiling; biomarker assay

(This special issue belongs to the Section Molecular Informatics)

Molecular Mechanisms Underlying Glomerular and Tubular Kidney Diseases

edited by

Gabriel Estrela

submission deadline 29 Jan 2027 | Viewed by 110 | Submission Open

Keywords: acute kidney injury (AKI); chronic kidney disease (CKD); glomerular injury; tubular epithelial cells; podocyte dysfunction; renal fibrosis; inflammation and immune response; epithelial–mesenchymal transition (EMT); mitochondrial dysfunction; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Perspectives on the Gut-Brain Axis: Multiomics, Machine Learning, and Therapeutic Interventions

edited by Gabriela Ibáñez-Cervantes and

Cindy Bandala

submission deadline 29 Jan 2027 | Viewed by 41 | Submission Open

Keywords: gut–brain axis; multi-omics integration; metagenomics and metabolomics; single-cell transcriptomics; machine learning algorithms; predictive computational models; psychobiotics and postbiotics; neuroinflammation; synaptic plasticity; metabolic diseases

(This special issue belongs to the Section Molecular Microbiology)

Calcium Homeostasis of Cells in Health and Disease: Third Edition

edited by

Péter Szentesi

and

László Csernoch

submission deadline 30 Jan 2027 | 6 articles | Viewed by 10667 | Submission Open

Keywords: Ca2+; calcium homeostasis; calcium-binding proteins; aging; disease

(This special issue belongs to the Section Biochemistry)

Exosomes and Extracellular Vesicles in Health and Diseases: 4th Edition

edited by

Manuela Zavatti

and

Francesca Beretti

submission deadline 30 Jan 2027 | 6 articles | Viewed by 4409 | Submission Open

Keywords: exosome; extracellular vesicles; network signals; biomarkers; pathological conditions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Substances from Plants: Discovery and Functional Characterization

edited by

Mohamed Ouknin

and

Lhou Majidi

submission deadline 30 Jan 2027 | 2 articles | Viewed by 1903 | Submission Open

Keywords: plant bioactive compounds; phytochemicals; natural products; functional characterization; phytochemical profiling; metabolomics; structure–activity relationships; biological activities

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Biology of Cancer—Implications for Diagnosis and Treatment: 4th Edition

edited by

Stergios Boussios

and

Tania Vanessa Pierfelice

submission deadline 30 Jan 2027 | 3 articles | Viewed by 1630 | Submission Open

Keywords: cancer molecular biology; tumor microenvironment; cancer biomarkers; precision oncology; cancer metabolism; translational cancer research

(This special issue belongs to the Section Molecular Oncology)

Recent Advances in Fungal–Host Interactions

edited by Julliana Ribeiro Alves Santos

submission deadline 30 Jan 2027 | Viewed by 276 | Submission Open

Keywords: fungal–host interactions; fungal pathogens in humans; fungal pathogens in plants; fungal–host molecular interaction; fungal pathogenicity; molecular basis of antifungal resistance

(This special issue belongs to the Section Molecular Immunology)

Plant-Derived Bioactives: Antioxidant Mechanisms and Preventive Health Strategies, 2nd Edition

edited by

Charles Manful

submission deadline 30 Jan 2027 | Viewed by 238 | Submission Open

Keywords: antioxidant; plant-derived bioactive compounds; flavonoids; oxidative stress; mechanisms of action

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Novel Structure and Function of Biological Molecules

edited by

Andrea Bernini

submission deadline 30 Jan 2027 | Viewed by 228 | Submission Open

Keywords: biological molecules; molecular structure; biomolecular function; structure–function relationships; molecular interactions; computational modeling; biophysical techniques

(This special issue belongs to the Section Molecular Biophysics)

Extracellular Vesicles in Tumor Growth and Progression

edited by

Josiah Ochieng

submission deadline 30 Jan 2027 | Viewed by 186 | Submission Open

Keywords: extracellular vesicles (EVs); tumor cells; secretion and uptake; metastasis; cancer biomarkers

(This special issue belongs to the Section Molecular Oncology)

Decoding the Exposome: Integrative Multi-Omics and Computational Toxicology for Precision Environmental Health

edited by

Ahsanullah Unar

submission deadline 30 Jan 2027 | Viewed by 176 | Submission Open

Keywords: exposome; multi-omics integration; computational toxicology; precision environmental health; environmental epigenomics; adverse outcome pathways; machine learning in toxicology; exposome-wide association studies; chemical risk assessment; systems toxicology

(This special issue belongs to the Section Molecular Informatics)

Chemical Biology Advance in Protein Conformational Diseases

edited by

Myriam M. Altamirano-Bustamante

and Nelly Altamirano-Bustamante

submission deadline 30 Jan 2027 | Viewed by 138 | Submission Open

Keywords: protein conformational diseases; misfolding and diseases; protein folding and diseases; amyloid proteins and diseases; diabetes; obesity; metabolic syndrome; Alzheimer diseases; cancer

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms and Therapeutic Targeting of Inflammatory Complications—2nd Edition

edited by

Kota V. Ramana

submission deadline 30 Jan 2027 | Viewed by 121 | Submission Open

Keywords: inflammation; oxidative stress; cytokines; autoimmune diseases; infectious diseases; cancer; targeted therapies; molecular pathways; asthma; sepsis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Prostate Cancer: Detection, Diagnosis and Treatment—a Contemporary Perspective

edited by

Mikhail Baryshev

submission deadline 30 Jan 2027 | Viewed by 102 | Submission Open

Keywords: prostate cancer; molecular biomarkers; cancer-specific DNA methylation; noncoding genes; gene fusions; lncRNA

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Gut Microbiota–Host Interaction

edited by

Vincent C. Lombardi

submission deadline 30 Jan 2027 | Viewed by 89 | Submission Open

Keywords: gut microbiota; host interaction; molecular mechanisms; microbiota-derived signals; host signaling networks; mucosal immunity; gastrointestinal barrier integrity

(This special issue belongs to the Section Molecular Microbiology)

Oxidative Stress in Disease: From Biomarkers to Clinical Translation

edited by

Joško Osredkar

submission deadline 30 Jan 2027 | Viewed by 54 | Submission Open

Keywords: oxidative stress; disease biomarkers; redox regulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Natural Products for Human Health and Disease

edited by

Rumyana Simeonova

submission deadline 31 Jan 2027 | 4 articles | Viewed by 20327 | Submission Open

Keywords: medicinal plants; phytochemistry; bioactive compounds; metabolomics; proteomics; antioxidants; signal transduction; immunomodulation; phytopharmacology; ethnopharmacology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

25th Anniversary of IJMS: Updates and Advances in "Materials Science" Section

edited by

Miklós Fried

and

Filippo Rossi

submission deadline 31 Jan 2027 | 15 articles | Viewed by 19911 | Submission Open

Keywords: nanomaterials; functional polymers; bio-inspired systems; complex intelligent; responsive materials

(This special issue belongs to the Section Materials Science)

Advancing Molecular Science Through Reproducible qPCR: MIQE Guidelines and Beyond

edited by

Stephen Bustin

submission deadline 31 Jan 2027 | 6 articles | Viewed by 17859 | Submission Open

Keywords: MIQE; qPCR; reverse transcription

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Animal Models for Human Diseases

edited by Yuning Song

submission deadline 31 Jan 2027 | 8 articles | Viewed by 17093 | Submission Open

Keywords: animal models; translational research; preclinical studies; biomedical innovation; reproducibility

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Supplements and Drug-Based Strategies in Neonatal and Paediatric Health

edited by

Giulia Malaguarnera

submission deadline 31 Jan 2027 | 3 articles | Viewed by 13250 | Submission Open

Keywords: neonatal pharmacology; paediatric supplements; nutraceuticals in early life; microbiota–host interactions; infectious diseases in children; neurodevelopmental disorders; drug–nutrient interactions; dosing and delivery routes; molecular paediatrics; critical analysis of paediatric interventions

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cutting-Edge Insights into Bacterial Infection and Host Immune Response

edited by

Pablo C. Baldi

submission deadline 31 Jan 2027 | 7 articles | Viewed by 12841 | Submission Open

Keywords: bacteria–host interaction; virulence factors; cellular and molecular immune response; immune evasion mechanisms

(This special issue belongs to the Section Molecular Microbiology)

New Insights into Adipose Tissue Metabolic Function and Dysfunction, 4th Edition

edited by

Federica Mannino

submission deadline 31 Jan 2027 | 6 articles | Viewed by 11938 | Submission Open

Keywords: inflammation; browning; thermogenesis; adipogenesis; diabetes; adipokines; energy storage; insulin resistance; obesity; lipolysis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Computational Approaches in Drug Discovery and Design: From Molecular Modeling to Translational Applications

edited by

Przemysław Czeleń

submission deadline 31 Jan 2027 | 6 articles | Viewed by 11905 | Submission Open

Keywords: computational drug discovery; molecular modeling; AI-driven drug design; molecular dynamics simulations; quantum chemistry; structure-based drug design; machine learning in pharmacology; virtual screening and docking; ADMET prediction; personalized medicine modeling

(This special issue belongs to the Section Molecular Informatics)

Psychedelics and Mental Disorders: From Molecular Mechanisms to Therapies Potential

edited by

Beatriz Caballero

and

Yaiza Potes

submission deadline 31 Jan 2027 | 2 articles | Viewed by 11038 | Submission Open

Keywords: psychedelics; drug-induced neurotoxicity; therapeutic potential; mental disorders; neuroprotective mechanisms; adult neurogenesis

(This special issue belongs to the Section Molecular Neurobiology)

Bone Metabolism and Bone Diseases

edited by

Giacomina Brunetti

submission deadline 31 Jan 2027 | 6 articles | Viewed by 10746 | Submission Open

Keywords: bone metabolism; bone diseases; osteoclast; osteoblasts and osteocytes; bone remodelling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innovative Molecular Target and Therapeutic Approaches in Fatty Liver Disease

edited by

Consolato M. Sergi

submission deadline 31 Jan 2027 | 1 articles | Viewed by 9092 | Submission Open

Keywords: liver; fatty liver disease; steatosis; rectors; ARA; THR-Beta; IL-22; glucagon; CRISPR-Case9; randomized clinical trials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomolecular Structure, Function and Interactions: 2nd Edition

edited by

Ivo Crnolatac

submission deadline 31 Jan 2027 | 6 articles | Viewed by 8739 | Submission Open

Keywords: biophysical chemistry; protein–protein interactions; protein–DNA interactions; protein–ligand interactions; receptor–ligand interactions; biomolecular structure and function; protein folding and stability

(This special issue belongs to the Section Biochemistry)

Colorectal Cancers: New Approach to Their Pathology, Diagnosis and Therapy

edited by

Mariusz Chabowski

submission deadline 31 Jan 2027 | 6 articles | Viewed by 8401 | Submission Open

Keywords: occult blood test; colorectal cancer; colonoscopy; rectal bleeding; abdominal pain; hemicolectomy; novel oncological drugs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Pathogen Interactions: 3rd Edition

edited by

Sixue Chen

submission deadline 31 Jan 2027 | 2 articles | Viewed by 8261 | Submission Open

Keywords: pathogenicity; plant immunity; pattern-triggered immunity (PTI); effector-triggered immunity (ETI); effectors; avirulent; virulent; biotroph; necrotrophy; interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Natural Compounds in Cancer Therapy: Molecular Mechanisms and Translational Potential

edited by

Gregory Christodoulidis

submission deadline 31 Jan 2027 | 2 articles | Viewed by 7934 | Submission Open

Keywords: natural compounds; cancer research; oxidative stress

(This special issue belongs to the Section Molecular Oncology)

Molecular Pathways, Microbiome, and Chronic Inflammatory Skin Diseases: Bridging the Gap

edited by

Oliver Seifert

submission deadline 31 Jan 2027 | 3 articles | Viewed by 7825 | Submission Open

Keywords: psoriasis; skin microbiome; chronic inflammatory skin diseases; molecular pathogenesis; biomarkers

(This special issue belongs to the Section Molecular Biology)

Circulating Biomarkers for the Diagnosis of Neurobiological Diseases—3rd Edition

edited by

Yasemin M. Akay

submission deadline 31 Jan 2027 | 1 articles | Viewed by 7399 | Submission Open

Keywords: circulating miRNAs; differently expressed genes; long COVID-19; neurobiological diseases; mesenchymal stem cells; circulating pasma exosomes; neuropathogenesis; proteomic analysis

(This special issue belongs to the Section Molecular Neurobiology)

Bioactive Compounds and Their Antioxidant Role: 2nd Edition

edited by Tamara Jurina

submission deadline 31 Jan 2027 | 5 articles | Viewed by 7172 | Submission Open

Keywords: bioactive compounds; antioxidants; polyphenolic compounds; nutraceuticals; phytochemicals; bioavailability; medicine

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Toxicology Research: Understanding and Predicting Compound-Induced Toxicity

edited by

Miriam Beatríz Virgolini

submission deadline 31 Jan 2027 | 5 articles | Viewed by 7167 | Submission Open

Keywords: toxicity; adverse-outcome pathway; metals; pesticides; drugs of abuse; pharmaceuticals

(This special issue belongs to the Section Molecular Toxicology)

Displaying special issue 2251-2300 on page 46 of 64.

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