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Molecular Mechanisms of Plant Nutrient Uptake and Signaling Networks

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Plant Sciences".

Deadline for manuscript submissions: 29 January 2027 | Viewed by 525

Editor


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Guest Editor
1. Department of Food Biotechnology, Albert Kázmér Mosonmagyaróvár Faculty, Széchenyi István University, H-9200 Mosonmagyaróvár, Hungary
2. Institute of Applied Plant Biology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Boszormenyi Street 138, 4032 Debrecen, Hungary
Interests: soil–plant–microbe interactions; rhizosphere biology; molecular mechanisms of nutrient uptake; PGPR; abiotic stress physiology and adaptive responses in plants; biofortification and plant metabolic responses; biogeochemistry of trace elements and environmental contaminants; sustainable soil fertility and biostimulants; food biotechnology; prebiotics and synbiotic; bioactive oligopeptides; plant-based proteases; functional foods
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Special Issue Information

Dear Colleagues,

Efficient nutrient acquisition is fundamental to plant growth, productivity, and resilience under fluctuating environmental conditions. Recent advances in molecular biology, genomics, and systems biology have significantly expanded our understanding of how plants perceive, transport, and regulate essential macro- and micronutrients. Key processes—including membrane transport, ion homeostasis, root system architecture modulation, and rhizosphere interactions—are governed by complex regulatory networks involving transporters, transcription factors, signaling peptides, and phytohormones. Furthermore, emerging insights into nutrient sensing and cross-talk between signaling pathways highlight the intricate coordination required to optimize nutrient use efficiency under stress conditions such as nutrient limitation, salinity, and climate variability.

This Special Issue aims to bring together cutting-edge research focusing on the molecular and mechanistic basis of nutrient uptake and utilization in plants. We welcome original research articles, reviews, and perspectives addressing topics such as transporter function and regulation, nutrient signaling pathways, gene regulatory networks, plant–microbe interactions influencing nutrient acquisition, and integrative omics approaches. Contributions exploring biotechnological strategies to enhance nutrient use efficiency and sustainable crop production are particularly encouraged. This Special Issue seeks to provide a comprehensive platform for advancing molecular-level understanding and translating these insights into agricultural innovation.

Dr. Tarek Alshaal
Guest Editor

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Keywords

  • rhizosphere interactions
  • ion homeostasis
  • transporter regulation
  • signal transduction
  • transcriptional control
  • nutrient use efficiency
  • root architecture
  • plant–microbe symbiosis
  • abiotic stress adaptation
  • omics integration

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Published Papers (1 paper)

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Review

37 pages, 1620 KB  
Review
Endocrine-Disrupting Pesticides as Drivers of Human Disease: Mechanistic Toxicology and Life-Course Health Effects
by Nour El-Hoda Zidan, Tarek Alshaal, Nevien Elhawat, Osama Elhamalawy, Farag Malhat and Fawzy Eissa
Int. J. Mol. Sci. 2026, 27(15), 6928; https://doi.org/10.3390/ijms27156928 - 1 Aug 2026
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Abstract
Endocrine-disrupting pesticides (EDPs) are environmental toxicants capable of perturbing hormonal homeostasis through multiple molecular and cellular mechanisms. Growing evidence indicates that these compounds contribute to a broad spectrum of adverse health outcomes extending beyond classical endocrine dysfunction. This review critically synthesizes current knowledge [...] Read more.
Endocrine-disrupting pesticides (EDPs) are environmental toxicants capable of perturbing hormonal homeostasis through multiple molecular and cellular mechanisms. Growing evidence indicates that these compounds contribute to a broad spectrum of adverse health outcomes extending beyond classical endocrine dysfunction. This review critically synthesizes current knowledge on the toxicological mechanisms of EDPs and evaluates epidemiological evidence linking exposure to human disease. Mechanistically, EDPs act through modulation of nuclear hormone receptors, disruption of membrane-associated signaling pathways, interference with hormone synthesis, metabolism, and transport, induction of oxidative stress and mitochondrial dysfunction, and epigenetic reprogramming. These molecular events converge on shared biological pathways that affect multiple organ systems and life stages. Human and experimental evidence associates EDP exposure with reproductive dysfunction, endocrine-related cancers, metabolic disorders, thyroid abnormalities, and neurodevelopmental impairments. Particular concern surrounds exposure during critical windows of susceptibility, especially prenatal development and early childhood, when endocrine systems are highly vulnerable to disruption and developmental programming. Across disease endpoints, recurring mechanisms, including endocrine receptor perturbation, oxidative stress, inflammation, and epigenetic alterations, support a unifying toxicological framework linking diverse adverse outcomes. Despite substantial progress, important uncertainties remain regarding chronic low-dose exposure, non-monotonic dose–response relationships, cumulative effects of pesticide mixtures, and the translation of mechanistic findings into human risk assessment. Future research should integrate repeated biomonitoring, advanced mixture modeling, mechanistic biomarkers, and multi-omics approaches within longitudinal life-course studies. Improved integration of toxicological and epidemiological evidence will strengthen causal inference, refine hazard characterization, and support more protective regulatory strategies for reducing the human health burden associated with endocrine-disrupting pesticides worldwide. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Plant Nutrient Uptake and Signaling Networks)
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