Molecular Mechanisms of Hypertension
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 10
Special Issue Editor
2. Department of Medicine, Division of Kidney Diseases & Hypertension, The George Washington University School of Medicine & Health Sciences, Washington, DC 20052, USA
Interests: angiotensin; dopamine; gene rescue; gene silencing; hypertension; ion and non-ion renal tubule cell transport; oxidative stress; pharmacogenetics; receptors; signal transduction; kidney research; pharmacology & physiology
Special Issue Information
Dear Colleagues,
Essential hypertension, which affects 30% of the adult population, is a complex disorder. The pathogenesis of hypertension involves a complex interplay between behavior, epigenetics, genetics, microbiome, and environment; these factors involve multiple organs, including the peripheral and central nervous, vascular, and endocrine systems. However, the kidney has the primary role in setting the blood pressure level in the long term. Among numerous environmental factors, sodium and potassium intake are particularly important. Decreased potassium and increased sodium intake increase blood pressure, especially in salt-sensitive individuals. In inverse-salt-sensitive individuals, decreased sodium intake paradoxically increases blood pressure, often to hypertensive levels, and is associated with increased end-organ damage. Several genes are involved in the effect of sodium on blood pressure. Some of these genes encode proteins expressed in the kidney that regulate sodium transport. However, other organs affect sodium balance. For example, the gastrointestinal tract, via gastrointestinal-derived hormones, regulates the autocrine function of renal hormones, affecting sodium excretion. Epigenetic responses to sodium intake also affect sodium excretion. This Special Issue addresses the molecular mechanisms of hypertension in different organ systems.
Prof. Dr. Pedro A. José
Guest Editor
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Keywords
- salt sensitivity
- inverse salt sensitivity
- epigenetics
- genetics
- organ-to-organ communication
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