Mitochondrial Signaling Pathways in Inflammation and Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 1
Special Issue Editors
Interests: nutraceuticals; mitochondria; membrane proteins; cell metabolism; cardiovascular disease; metabolic syndrome
Special Issues, Collections and Topics in MDPI journals
Interests: mitochondria; bioenergetics; mitochondrial diseases; apoptosis; ATP synthase; oxidative stress; mitochondrial dysfunction; respiratory chain; cellular energy metabolism; mitochondrial-derived vesicle-mediated signaling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
It is widely accepted that mitochondria, in addition to being responsible for cellular energy metabolism, are involved in regulating the inflammatory response.
In fact, in recent years, in-depth biochemical studies have demonstrated that stress conditions compromise mitochondrial integrity, resulting in the leakage of mitochondrial DNA (mtDNA) into the cytosol. mtDNA functions as a damage-associated molecular pattern (DAMP) that activates the stimulator of the interferon gene (STING) expression pathway, resulting in pathological inflammation.
In particular, a growing number of studies have demonstrated that the cGAS-STING signaling pathway is aberrantly activated by the release of cytosolic mtDNA, and this is implicated in multiple pathologies, such as cardiovascular disease, cancer, metabolic diseases, neurodegenerative diseases, and immunometabolic disorders.
Therefore, in light of this, it is important for the scientific community to increase our knowledge of mitochondrial dysfunction in order to better understand the interrelationship between different cellular mechanisms.
In particular, we encourage submission of original manuscripts and reviews that provide new insights and information on the biochemical interaction of potential mitochondrial dysfunction with cellular metabolism, in health and disease, to design new and innovative therapeutic approaches.
Dr. Francesca Oppedisano
Dr. Cristina Algieri
Guest Editors
Manuscript Submission Information
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Keywords
- mitochondria
- cell metabolism
- inflammatory mitochondrial signalling
- metabolic pathways
- mitochondrial dysfunction
- mtDNA
- cGAS-STING pathway
- NLRP3 inflammasome
- human pathology
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