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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Toxicological Impacts of Emerging Contaminants on Aquatic Organisms

edited by

Mohamed Hamed

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1574 | Submission Open

Keywords: aquatic toxicology; emerging contaminants; physiology and behavior; oxidative stress; antioxidant biomarkers; immunotoxicity; neuroendocrine toxicity; bioremediation; molecular mechanisms

(This special issue belongs to the Section Molecular Toxicology)

Gynecological Oncology: From Molecular Basis to Therapy

edited by

Martin Götte

and Lars Hanker

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1531 | Submission Open

Keywords: gynecological oncology; molecular basis; targeted therapy; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Advancing Liver Health: State of the Art and Recent Research Advances

edited by

Chase Wehrle

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1526 | Submission Open

Keywords: liver; liver cancer and malignancy; liver transplantation; inflammation and immunity; liver health and ageing; molecular genomics; cellular senescence; metabolic dysfunction-associated liver disease; cirrhosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Natural Compounds in Neuroscience

edited by

Sarmistha Mitra

submission deadline 20 Feb 2026 | Viewed by 1520 | Submission Open

Keywords: natural products; bioactive metabolites; secondary metabolites; neuronal development; neurotrophins; neuromedicine; neurodegeneration; memory disorders

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into the Role of Exercise in Disease and Health, 2nd Edition

edited by

Brisamar Estébanez

, María José Cuevas-González and Chun-Jung Huang

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1494 | Submission Open

Keywords: physical activity; molecular mechanisms; disease prevention; metabolic health; cardiovascular diseases; neurodegenerative diseases; sarcopenia; immune function; healthy aging; epigenetics

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Tumorigenesis of Human and Animal Stem Cells

edited by

Daniela Salvatori

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1488 | Submission Open

Keywords: malignancy; stem cells; safety; chromosal aberrations; animal; human; teratoma assay; in vitro assays

(This special issue belongs to the Section Molecular Oncology)

Research on Alloy Materials Microstructure and Their Functionalization

edited by

Ozkan Gokcekaya

and Celaletdin Ergun

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1475 | Submission Open

Keywords: alloy design; microstructure; production methods; additive manufacturing; sol– gel process; biofunctional materials; magnetic properties; nanoparticles; ceramics; composites

(This special issue belongs to the Section Materials Science)

Molecular Biology of Periodontal Disease and Periodontal Pathogens

edited by Yago Leira and

João Botelho

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1463 | Submission Open

Keywords: periodontitis; general medicine; inflammation; bacteraemia; education

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Parasitic Infection

edited by Marcin Wiśniewski and

Piotr Bąska

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1411 | Submission Open

Keywords: parasitic infections; host– parasite interactions; parasite genomics; drug-resistance mechanisms; transcriptomics; proteomics; diagnostic tools; immune evasion; therapeutic strategies

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research and Insight in Neurotransmission and Neuromodulation

edited by Miklos Jaszberenyi

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1400 | Submission Open

Keywords: histology; microanatomy; morphology; molecular biology; neurotransmitter; neuromodulator; neuropeptide; neurohormone; nervous system

(This special issue belongs to the Section Molecular Neurobiology)

Biomechanics and Molecular Research on Glioblastoma: 2nd Edition

edited by

Lorenzo Corsi

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1398 | Submission Open

Keywords: GBM; molecular pathways; biomechanics; oncogene; cancer; microenvironment; drug targeting; diagnostic; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Harnessing Bioinformatics for miRNA Research: Methods, Insights and Applications

edited by Maria Rosaria Tumolo and Saverio Sabina

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1352 | Submission Open

Keywords: microRNA; bioinformatics; hub genes; miRNA target prediction; miRNA regulatory networks; miRNA-based biomarkers; artificial intelligence in miRNA research; multi-omics approaches

(This special issue belongs to the Section Molecular Informatics)

Advances in Vitiligo: From Mechanisms to Treatment Innovations

edited by Hyun Jeong Ju

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1349 | Submission Open

Keywords: autoimmune disease; cytokine signaling; depigmentation; immunotherapy; melanocyte regeneration; microbiome; oxidative stress; vitiligo

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Plant Cell Wall: Structural Dynamics, Functions, and Future Innovations

edited by

Ioannis-Dimosthenis Adamakis

and

Kosmas Haralampidis

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1348 | Submission Open

Keywords: plant cell wall; biosynthesis; biomass; abiotic stress; biotic stress; renewable resources; biotechnology; climate change

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Interactions and Advanced Computational Methods for Biomolecular Systems

edited by

Amar Singh

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1347 | Submission Open

Keywords: molecular interactions; biological systems; computational biology; protein– protein interactions; protein docking; bioinformatics; structural modeling; multiscale modeling techniques

(This special issue belongs to the Section Molecular Biophysics)

Molecular Mechanisms and Therapeutic Strategies of Colorectal Cancer

edited by

Daniel Gabriel Pons

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1345 | Submission Open

Keywords: colorectal cancer; tumor microenvironment; biomarkers; intercellular communication; therapeutic strategies

(This special issue belongs to the Section Molecular Oncology)

Advanced Research on Plant-Derived Products in the Service of Immune Regulation

edited by

Lyuba Dineva Miteva

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1332 | Submission Open

Keywords: plant bioactive compound; inflammation; immunity; cytokine; chronic disease

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms and Neural Circuits in Behavioral Neuroscience

edited by Matteo Di Segni and Rossella Ventura

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1289 | Submission Open

Keywords: behavioral neuroscience; neural circuits; psychopathology; neuroscience; drug addiction; depression; mental illness

(This special issue belongs to the Section Molecular Neurobiology)

Microbiome-Immunity Crosstalk and Its Role in Health and Disease

edited by

Ana Isabel Beltrán-Velasco

and Sara Uceda

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1272 | Submission Open

Keywords: gut microbiota; immune system; nutrition; inflammatory processes; dysbiosis; neurodegenerative diseases

(This special issue belongs to the Section Molecular Microbiology)

The Toxicity of Bisphenol A and Its Analogs

edited by

Krystyna Makowska

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1206 | Submission Open

Keywords: bisphenols; endocrine disruptors; bisphenol A and analogs; toxicology

(This special issue belongs to the Section Molecular Toxicology)

Novel Insights into Buckwheat Reproductive Biology

edited by

Agnieszka Płażek

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1151 | Submission Open

Keywords: antioxidant properties; biotechnological methods; embryology; seed chemical composition; yield

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms Linking Obesity to Atherosclerosis Pathogenesis

edited by

Weibin Shi

submission deadline 20 Feb 2026 | 1 articles | Viewed by 995 | Submission Open

Keywords: obesity; overweight; atherosclerosis; coronary artery disease; obesity paradox; body mass index; visceral fat

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neuromodulatory Effects of Serotonin, 2nd Edition

edited by

Yasemin M. Akay

submission deadline 20 Feb 2026 | 1 articles | Viewed by 976 | Submission Open

Keywords: neuromodulation; Serotonin; pain research; cognition; emotions; depression; anxiety; GBM

(This special issue belongs to the Section Molecular Neurobiology)

The Environment, Human Stress, and Gut Microbiome: A Triad in Disease Development

edited by

Natalia Kurhaluk

and Halina Tkaczenko

submission deadline 20 Feb 2026 | 1 articles | Viewed by 976 | Submission Open

Keywords: gut microbiome stress interactions; environmental microbiome disease linkages; stress-driven microbiome dysbiosis; microbiome environment disease pathways; human microbiome stress responses; environmental stress disease mechanisms; gut microbiome oxidative stress interactions; environmental oxidative stress impacts; stress-driven microbiome oxidative imbalance; oxidative stress microbiome diseases; human oxidative stress pathways; oxidative stress disease mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Cancer Progression and Therapeutic Resistance Mechanisms

edited by

Fabrizio Fontana

submission deadline 20 Feb 2026 | 1 articles | Viewed by 968 | Submission Open

Keywords: cancer drug resistance; growth factors; DNA repair; miRNAs; ABC transporters; cancer stem cells; extracellular vesicles; circulating cancer cells; circulating cancer DNA; liquid biopsies; natural anticancer compounds

(This special issue belongs to the Section Molecular Oncology)

Metabolic Dynamics and Immune Surveillance in the Tumor Microenvironment

edited by

Jyoti Kaushal

submission deadline 20 Feb 2026 | 1 articles | Viewed by 934 | Submission Open

Keywords: cancer; TME; metabolism; immune cells; signaling pathway; therapy

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Cardiovascular Research: From Molecular Mechanisms to Novel Therapies

edited by Piotr Musiałek, Monika M. Gladká and Lukasz Tekieli

submission deadline 20 Feb 2026 | 1 articles | Viewed by 863 | Submission Open

Keywords: cardiovascular diseases; cardiovascular repair and regeneration; molecular cardiology; gene and stem cell therapy; drug and gene delivery; advanced imaging; biomarkers; tissue engineering; thrombosis and clotting abnormalities; animal models of human disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Beyond the Gene: Molecular Circuits Shaping Plant Cells and Tissues

edited by

Tarek Alshaal

submission deadline 20 Feb 2026 | Viewed by 858 | Submission Open

Keywords: cell function; cell polarity; tissue organization; transporter; localization

(This special issue belongs to the Section Molecular Plant Sciences)

Therapeutic Potential: Exploring Membrane Transporters and Channels as Drug Targets

edited by

Jinwei Zhang

submission deadline 20 Feb 2026 | Viewed by 847 | Submission Open

Keywords: membrane transporters; channels; drug targets; therapeutic potential; neurological disorders; metabolic syndromes; methodologies; mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Degradable Polymers: Synthesis, Applications, and Environmental Impact

edited by Ce Sun and

Haiyang Gao

submission deadline 20 Feb 2026 | 1 articles | Viewed by 776 | Submission Open

Keywords: degradable polymer; synthesis; degradation mechanisms; sustainability

(This special issue belongs to the Section Macromolecules)

Iron and Sulfur in Plants, 4th Edition

edited by

Stefania Astolfi

and

Silvia Celletti

submission deadline 20 Feb 2026 | Viewed by 742 | Submission Open

Keywords: biofortification; Fe– S clusters; iron; iron deficiency; metabolites; methionine; nutrient interaction; root exudates; strategy I; strategy ii; sulfur; sulfur deficiency

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Nanomaterial-Mediated Immune Modulation

edited by

Ivan Kempson

submission deadline 20 Feb 2026 | Viewed by 732 | Submission Open

Keywords: nanomaterial; immune modulation; immunological responses

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Mechanisms Underlying Skin Diseases

edited by Maria Lucia Dell'Anna

submission deadline 20 Feb 2026 | 1 articles | Viewed by 727 | Submission Open

Keywords: pigmentation; lipid signaling; immune cells; inflammation; skin barrier; oxidative damage; mitochondria

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Molecular Mechanisms and Targeted Therapies for Leukemia

edited by

Moo Kon Song

submission deadline 20 Feb 2026 | Viewed by 706 | Submission Open

Keywords: targeted therapy; acute myeloid leukemia; genetic mutations

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Targeted Therapy of Lymphedema and Lipedema

edited by

Raghu P. Kataru

and Geoffrey E. Hespe

submission deadline 20 Feb 2026 | Viewed by 699 | Submission Open

Keywords: secondary lymphedema; breast cancer related lymphedema; chronic CD4+ T cell inflammtion Th2 driven fribrosis; lymphatic pathophysiology; tissue fibrosis; lymphovenous bypass; lymph node transplanatation; targeted therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Study on the Microenvironment in Lymphoma

edited by

Jonathan P. Butchar

submission deadline 20 Feb 2026 | 2 articles | Viewed by 689 | Submission Open

Keywords: tumor microenvironment; lymphoma; hodgkin lymphoma; non-hodgkin lymphoma; burkitt lymphoma; follicular lymphoma; waldenströ m’ s macroglobulinemia; NK/T-cell lymphoma; diffuse large B-cell lymphoma; mantle cell lymphoma; marginal zone lymphoma; lymphoproliferative disorder; anaplastic large cell lymphoma; mediastinal B cell lymphoma; T-cell lymphomas

(This special issue belongs to the Section Molecular Oncology)

Vitamin K in Disease Mechanisms and Therapy

edited by Maria Kokozidou

submission deadline 20 Feb 2026 | Viewed by 655 | Submission Open

Keywords: vitamins K; vitamins K-soluble proteins; vitamin K-dependent clotting factors; matrix Gla protein; calcification of blood vessels; vascular stiffness; cardiac output; stroke volume

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Histological Approaches in Oral Tissue Regeneration and Diagnostics

edited by

Fabiana Nicita

submission deadline 20 Feb 2026 | 1 articles | Viewed by 636 | Submission Open

Keywords: dentistry; histological analysis; immunofluorescence; molecular pathogenesis; tissue

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Cellular Neurobiology of Headache and Migraine

edited by

Mamoru Shibata

submission deadline 20 Feb 2026 | 1 articles | Viewed by 562 | Submission Open

Keywords: headache; migraine; calcitonin gene-related peptide (CGRP); spreading depolarization/depression; TRP channels; pituitary adenylate cyclase-activating polypeptide; PACAP; cluster headache

(This special issue belongs to the Section Molecular Neurobiology)

The Role of Melatonin in Plants: 3rd Edition

edited by

Małgorzata M. Posmyk

submission deadline 20 Feb 2026 | 1 articles | Viewed by 559 | Submission Open

Keywords: melatonin; phytomelatonin; plants; seed germination; seasonal and circadian rhythms; flowering; fruit ripening; plant immunity; abiotic stresses

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Linkages Between Obesity, Diabetes and Cancer

edited by Pilar F. Valerón

submission deadline 20 Feb 2026 | Viewed by 537 | Submission Open

Keywords: obesity; GLUT4; PPARg; lipid transporters (CD36 and AQP7); cancer progression; metastasis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanisms in Biofilm Formation, Tolerance and Control: 3rd Edition

edited by

Manuel Simões

and Lúcia Chaves Simões

submission deadline 20 Feb 2026 | Viewed by 529 | Submission Open

Keywords: adhesion; antimicrobial action; antimicrobial resistance; biofilm development; biofilm matrix; biofilm structure; quorum sensing; motility; surfaces

(This special issue belongs to the Section Molecular Microbiology)

Cellular Senescence as a Therapeutic Target in Cancer: Mechanisms, Challenges, and Therapeutic Opportunities

edited by

Mi Kyung Park

submission deadline 20 Feb 2026 | Viewed by 525 | Submission Open

Keywords: cellular senescence; cancer therapy; therapeutic targeting; senolytic drugs; senescence-associated secretory phenotype (SASP)

(This special issue belongs to the Section Molecular Oncology)

Advances in Heparin, Heparan Sulfate and Heparanase, 2nd Edition

edited by

Nobuaki Higashi

submission deadline 20 Feb 2026 | Viewed by 521 | Submission Open

Keywords: allergy; angiogenesis; cancer metastasis; cellular trafficking; exosome; fibrosis; glycocalyx; glycosaminoglycans; heparan sulfate; heparanase; heparin; immune responses; inflammation; inbibitor development; sepsis/SIRS (systemic inflammatory response syndrome); sulfatase; viral infections

(This special issue belongs to the Section Macromolecules)

Role of Quorum Sensing in Plant Microbiome: Advances and Prospects

edited by

Clarisse Brígido

submission deadline 20 Feb 2026 | Viewed by 502 | Submission Open

Keywords: quorum sensing; quorum quenching; rhizosphere signaling; signaling molecules; N-Acyl-L-homoserine lactones; AHLs; microbiome; chemical molecules; sustainable agriculture

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Molecular Research of Facial Adipose Compartments

edited by Marius Valeriu Hînganu

submission deadline 20 Feb 2026 | Viewed by 496 | Submission Open

Keywords: facial fat; facial adipose tissue; molecular markers of facial fat; hormonal environmental; metabolic disorders; facial deformities; single-cell RNA sequencing; CRISPR-Cas9 gene editing

(This special issue belongs to the Section Molecular Biology)

Advancements and Applications of Phyto-Nanotherapy in Targeted Disease Treatment

edited by

Adewale Fadaka

and

Nicole Remaliah Samantha Sibuyi

submission deadline 20 Feb 2026 | Viewed by 495 | Submission Open

Keywords: phyto-nanotherapy; medicinal plants; nanoparticles; targeted drug delivery; phytochemicals; phytotherapy; green nanotechnology; chronic diseases; infectious diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Treatment in Skin Cancer

edited by

Jànos Hunyadi

submission deadline 20 Feb 2026 | 1 articles | Viewed by 480 | Submission Open

Keywords: skin cancer; early detection; treatment; prevention; pathophysiology; vitamin-C; cell energetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Endometrial Function in Women with Polycystic Ovary Syndrome: Molecular Data

edited by

Stefano Palomba

submission deadline 20 Feb 2026 | Viewed by 479 | Submission Open

Keywords: endometrium; infertility; polycystic ovary syndrome; PCOS; receptivity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Quantum Chemical Approaches for Investigating Reaction Mechanisms in Organic Chemistry

edited by

Robert O'Reilly

submission deadline 20 Feb 2026 | Viewed by 473 | Submission Open

Keywords: organic chemistry; biochemistry; density functional theory; coupled cluster theory; free radicals; reaction mechanisms; transition states

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Displaying special issue 1751-1800 on page 36 of 70.

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