Cellular Senescence as a Therapeutic Target in Cancer: Mechanisms, Challenges, and Therapeutic Opportunities

Dear Colleagues,

This Special Issue aims to delve into the intricate mechanisms that govern the induction of cellular senescence, explore its dual role in both tumor suppression and promotion, and address the challenges and therapeutic opportunities presented by targeting senescent cells in cancer therapy.

Cellular senescence is a complex biological process characterized by a permanent state of cell cycle arrest, often acting as a natural barrier to cancer development. However, senescent cells can also contribute to tumor progression and therapy resistance through their secretory phenotype. Understanding the delicate balance between these opposing roles is crucial for developing effective cancer therapies.

Through this Special Issue, we aim to provide a comprehensive overview of the current state of research on cellular senescence in cancer, highlight emerging therapeutic strategies, and foster a deeper understanding of the senescence–cancer axis. We look forward to receiving your contributions and advancing the field together.

Dr. Mi Kyung Park
Guest Editor

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