Cellular Senescence as a Therapeutic Target in Cancer: Mechanisms, Challenges, and Therapeutic Opportunities
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 August 2025 | Viewed by 398
Special Issue Editor
2. Department of Bio-Healthcare, Hwasung Medi-Science University, Hwaseong-si 18274, Republic of Korea
Interests: molecular mechanism; tumor microenvironment; epithelial-to-mesenchymal transition (EMT); post-translational modification (PTM); autophagy; potential therapeutic approaches; preclinical mouse models for cancers; breast cancer; liver cancer; lung cancer; pancreatic cancer; cancer progression and metastasis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue aims to delve into the intricate mechanisms that govern the induction of cellular senescence, explore its dual role in both tumor suppression and promotion, and address the challenges and therapeutic opportunities presented by targeting senescent cells in cancer therapy.
Cellular senescence is a complex biological process characterized by a permanent state of cell cycle arrest, often acting as a natural barrier to cancer development. However, senescent cells can also contribute to tumor progression and therapy resistance through their secretory phenotype. Understanding the delicate balance between these opposing roles is crucial for developing effective cancer therapies.
Through this Special Issue, we aim to provide a comprehensive overview of the current state of research on cellular senescence in cancer, highlight emerging therapeutic strategies, and foster a deeper understanding of the senescence–cancer axis. We look forward to receiving your contributions and advancing the field together.
Dr. Mi Kyung Park
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cellular senescence
- cancer therapy
- therapeutic targeting
- senolytic drugs
- senescence-associated secretory phenotype (SASP)
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
