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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cardiovascular Diseases: From Molecular Diagnosis to Treatment

edited by

Li Wang

submission deadline 31 Aug 2026 | 2 articles | Viewed by 3228 | Submission Open

Keywords: cardiovascular diseases; molecular diagnosis; multi-omics approaches; liquid biopsies; molecular imaging; gene and cell therapies; nanomedicine; pharmacogenomics; targeted molecular therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Neuropeptides and Their GPCRs in the Neuroendocrine System

edited by

Hirotaka Sakamoto

submission deadline 31 Aug 2026 | 1 articles | Viewed by 3225 | Submission Open

Keywords: neuropeptides; G-protein-coupled receptors (GPCRs); neuroendocrine system; signal transduction; hypothalamus

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Zoology: 2nd Edition

edited by

Valeria Maselli

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2911 | Submission Open

Keywords: zoology; genomics; transcriptomics; phylogeny; molecular evolution; mtDNA; eDNA; RNA; molecular zoology

(This special issue belongs to the Section Molecular Biology)

Bioactivity and Mechanistic Insights of Plant-Derived Chemical Compounds

edited by

Mohammed Dalli

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2767 | Submission Open

Keywords: plant-derived compounds; bioactivity; mechanism of action; phytochemicals; pharmacology; natural products; molecular targets; ethnopharmacology; drug discovery; translational research

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Exploring Melatonin and Related Indolic Agents

edited by

Burkhard Poeggeler

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2623 | Submission Open

Keywords: aging; antioxidant; bioenergetic agent; biological clock; immunomodulation; indole-3-propionic acid; indole-3-propionamide; melatonin; senescence; tryptophan

(This special issue belongs to the Section Molecular Pharmacology)

Role of Integrins in Cytokine Signaling

edited by

Yoshikazu Takada

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2276 | Submission Open

Keywords: integrins; cytokines; FGF1; CX3CL1; ternary-complex; antagonist; inside-out signaling; integrin-binding motif; cytokine-integrin crosstalk; ligand-induced activation

(This special issue belongs to the Section Molecular Biology)

MicroRNA and Non-Coding RNA: From Basic Research to Potential Clinical Application—2nd Edition

edited by

Erika Cione

and

Diana Abrego-Guandique

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2275 | Submission Open

Keywords: microRNA; non-coding RNA; gene regulation; biomarkers; RNA therapeutics; extracellular vesicles; microarray; NGS

(This special issue belongs to the Section Molecular Genetics and Genomics)

Sjogren's Disease: Multidimensional Perspectives on Pathogenesis, Clinical Manifestations, and Therapeutic Advancements (2nd Edition)

edited by

Xiang Lin

submission deadline 31 Aug 2026 | 5 articles | Viewed by 2236 | Submission Open

Keywords: Sjögren's disease; diagnosis; therapeutics; bioinformatics; pre-clinical; cytokine; lymphocytes; autoantibodies; exocrine glands

(This special issue belongs to the Section Molecular Immunology)

Advances in the Molecular Diagnosis and Treatment of Neurodegenerative Diseases

edited by

Bruno Manadas

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2180 | Submission Open

Keywords: neurodegenerative disorders; biomarkers; treatment; omics; systems biology

(This special issue belongs to the Section Molecular Neurobiology)

Advanced In Vitro Systems for Mechanistic Toxicology

edited by

João Pedro Silva

and

Félix Carvalho

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2150 | Submission Open

Keywords: mechanistic toxicology; organ-on-chip; microphysiological systems; human iPSC models; organoids; AI/ML modeling; multi-omics; high-content screening; 3D cell cultures

(This special issue belongs to the Section Molecular Toxicology)

The Toxicity of Bisphenol A and Its Analogs

edited by

Krystyna Makowska

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2135 | Submission Open

Keywords: bisphenols; endocrine disruptors; bisphenol A and analogs; toxicology

(This special issue belongs to the Section Molecular Toxicology)

Techniques and Applications of Forensic Molecular Biology: From Pathology to Clinical Practice

edited by

Angelo Montana

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2120 | Submission Open

Keywords: biomarkers; immunohistochemistry; histopathology; forensic pathology; forensic toxicology; forensic biomarkers; toxicological biomarkers; neuropathology; mRNA; post-mortem interval; cerebral damage; in vitro, in vivo, and in silico models; hypoxic–ischemic brain injury; pregnancy biomarkers; vitality

(This special issue belongs to the Section Molecular Biology)

Nutrition, Inflammation and Chronic Kidney Diseases

edited by

Rodolfo A. Valtuille

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2071 | Submission Open

Keywords: chronic kidney disease; nutrition; inflammation; bioimpedance; gut-kidney axis; uremic toxins; oxidative stress; protein-energy wasting; precision nutrition; biomarkers

(This special issue belongs to the Section Molecular Immunology)

DNA Methylation Dynamics Due to Environmental Factors and in Human Diseases

edited by

Naila Francis Paulo De Oliveira

and

José Maria Chagas Viana Filho

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2064 | Submission Open

Keywords: inflammatory diseases; mental diseases; tumour diseases; epidrugs; exposure biomarkers; epigenetic drugs

(This special issue belongs to the Section Molecular Genetics and Genomics)

Hydrogen Medicine: From Molecular Insights to Disease Intervention

edited by

Fei Xie

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1822 | Submission Open

Keywords: hydrogen medicine; molecular hydrogen; oxidative stress; inflammation; mitochondrial function; gasotransmitters; ischemia–reperfusion injury; clinical trials; signal transduction; bioinformatics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Cellular Mechanisms of Vaccine-Induced Immune Responses

edited by In Ohk Ouh

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1803 | Submission Open

Keywords: vaccine platforms; molecular mechanisms; innate immune sensing; adaptive immune responses; adjuvants and signaling pathways; antigen processing and presentation; immunological memory; systems immunology

(This special issue belongs to the Section Molecular Immunology)

Molecular Targets and Toxic Interactomes of Pathogenic Proteins in Neurodegeneration

edited by

Kohji Fukunaga

and Ichiro Kawahata

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1762 | Submission Open

Keywords: neurodegenerative diseases; tau protein; TDP-43; α-synuclein; endoplasmic reticulum stress; mitochondrial toxicity; liquid–liquid phase separation; toxic Interactomes

(This special issue belongs to the Section Molecular Neurobiology)

Degradable Polymers: Synthesis, Applications, and Environmental Impact

edited by Ce Sun and

Haiyang Gao

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1758 | Submission Open

Keywords: degradable polymer; synthesis; degradation mechanisms; sustainability

(This special issue belongs to the Section Macromolecules)

Mathematical Computation and Modeling in Biology

edited by

Shinuk Kim

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1749 | Submission Open

Keywords: mathematical model; computational methods; systemic molecular interaction; machine learning; integrating molecular materials

(This special issue belongs to the Section Molecular Informatics)

Intermittent Hypoxia and Physiological Effects: Interplay Between Oxidative Stress, Inflammation, and Autonomic Dysregulation

edited by

Rodrigo L. Castillo

and

Esteban G. Figueroa

submission deadline 31 Aug 2026 | 3 articles | Viewed by 1655 | Submission Open

Keywords: intermittent hypoxia; cardiovascular and pulmonary effects; oxidative stress; autonomic dysfunction; neuroinflammation; renal effects; animal models

(This special issue belongs to the Section Molecular Biology)

Feature Papers in ‘Physical Chemistry and Chemical Physics’: Fifth Edition

edited by

Dongho Kim

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1596 | Submission Open

Keywords: heterogeneous structures; alignment and surface phenomena; quantum theory; mathematical physics; statistical and classical mechanics; molecular structure; chemical kinetics; laser physics; dynamics; kinetics; photochemistry; spectroscopy; exciton dynamics; statistical mechanics; thermodynamics; electrochemistry; catalysis; surface science; quantum mechanics; theoretical developments; fundamental aspects of catalysis; solar energy conversion; polymer dynamics

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Ion Channels in Health and Disease: From Physiology to Therapeutics

edited by

Yohan Seo

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1574 | Submission Open

Keywords: ion channels; cellular homeostasis; chronic diseases; cancer; inflammation; therapeutic targets; drug resistance; channel modulators; translational medicine

(This special issue belongs to the Section Molecular Biology)

Precision Medicine in Cancer: Biomarker and Bioinformatics Research

edited by

Youping Deng

and

Shaoqiu Chen

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1472 | Submission Open

Keywords: precision medicine; cancer biomarkers; bioinformatics; multi-omics; machine learning; tumor heterogeneity

(This special issue belongs to the Section Molecular Informatics)

Metabolic Sensing and Adaptive Stress Responses in Aging and Chronic Disease

edited by Mark Slevin

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1458 | Submission Open

Keywords: metabolic sensing; aging and healthspan; exercise physiology; AMPK–mTOR signaling; autophagy and mitophagy; redox biology; mitochondrial quality control; cellular stress adaptation; chronic disease prevention; inflammaging

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Metabolic Bone Disorders

edited by

Harish K. Datta

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1329 | Submission Open

Keywords: metabolic bone disease; bone cells; rare diseases; genetics; molecular biology; skeletal development disorders

(This special issue belongs to the Section Molecular Biology)

Programmed Cell Death and Oxidative Stress: 4th Edition

edited by

Takuya Noguchi

submission deadline 31 Aug 2026 | 3 articles | Viewed by 1314 | Submission Open

Keywords: oxidative stress; programmed cell death; cellular stresses; senescence; cytotoxicity; cancer; neurodegenerative disease; inflammatory disease; organelle stress

(This special issue belongs to the Section Biochemistry)

Brain–Organ Axis and Related Neurodegeneration

edited by

Nan-Shan Chang

and

Hieu-Huy Nguyen-Tran

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1277 | Submission Open

Keywords: brain–organ axis; microbiota–gut–brain axis; neurodegenerative diseases; neuroinflammation; signaling pathways and alterations; innate immunity

(This special issue belongs to the Section Molecular Neurobiology)

New Advances in Functional Nanomaterials, Nanomedicines and Biosensors Based on Nucleic Acids

edited by

Yuancong Xu

and Peng Cao

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1230 | Submission Open

Keywords: nucleic acids; functional nanomaterials; nanomedicine; biosensors; DNA nanotechnology; delivery systems; self-assembly; biomedical imaging; clinical applications; diagnostics

(This special issue belongs to the Section Molecular Nanoscience)

Recent Advances in Non-Coding RNAs in Human Research

edited by

Jesús Adrián López

submission deadline 31 Aug 2026 | 3 articles | Viewed by 1228 | Submission Open

Keywords: microRNAs; lncRNAs; mRNA regulation; cell signaling pathways; RNA methylation; RNA phosphorylation; RNA deamidation; cell communication; chemoresistance; RNA inhibitors or activators

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular and Nanostructured Materials for Energy, Environmental, and Biomedical Applications

edited by

Balaji Murugan

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1198 | Submission Open

Keywords: advanced sustainable materials; molecular engineering; energy conversion and storage (supercapacitor, solar cells, and batteries); electrocatalysis and photocatalysis; environmental remediation; biomedical applications; bio/electrochemical sensing and bioelectronics; molecular surface structure and interface chemistry; in situ/operando spectroscopy

(This special issue belongs to the Section Molecular Nanoscience)

Advanced Molecular Research on Kidney Diseases

edited by Joan Torras and Laura Martinez Valenzuela

submission deadline 31 Aug 2026 | 3 articles | Viewed by 1196 | Submission Open

Keywords: renal genomics; molecular; proteomics and metabolomics; cellular mechanisms and biomarkers; therapeutic innovations; translational and precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Vascular Function, Senescence and Remodeling: A New Direction for Therapeutic Approach to Prevent CVDs

edited by

Gautham Yepuri

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1164 | Submission Open

Keywords: vascular dysfunction; senescence; endothelial cells; small molecules; anti-aging; cardiovascular diseases; sudden death

(This special issue belongs to the Section Molecular Biology)

The Placental Barrier: From Fundamental Mechanisms to Clinical Implications

edited by

Ricardo Emilio Fretes

and María I. De La Calle

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1156 | Submission Open

Keywords: placental barrier; maternal–fetal interface; pregnancy pathologies; vertical transmission

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Imprinting Technologies for Biological and Biomedical Applications

edited by

Urtė Prentice

and

Simonas Ramanavičius

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1153 | Submission Open

Keywords: molecularly imprinted polymers; biosensors and diagnostics; biomolecular recognition; molecular imprinting; nanomaterials; molecular biology applications

(This special issue belongs to the Section Molecular Informatics)

Traditional and Emerging Molecular Approaches for Enhancing Genetic Gain in Plant Breeding

edited by

Fozia Ghouri

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1152 | Submission Open

Keywords: genome editing and engineering; marker-assisted selection; molecular mechanisms of stress adaptation; epigenetics and gene regulation; speed breeding and molecular markers; artificial intelligence; omics and biotechnological technologies

(This special issue belongs to the Section Molecular Plant Sciences)

Immune Regulatory Mechanisms in the Pathogenesis of Autoimmunity

edited by

Elias Toubi

and

Vadasz Zahava

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1125 | Submission Open

Keywords: immune regulation; soluble regulatory molecules; autoimmunity

(This special issue belongs to the Section Molecular Immunology)

Advanced Optical Imaging and Spectroscopy: Bridging Technical Innovation and Molecular Insights in Biomedicine

edited by Kanwarpal Singh and Sharma Gargi

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1116 | Submission Open

Keywords: optical imaging; biomedical spectroscopy; multimodal imaging; molecular imaging; label-free diagnostics; photonic instrumentation; in vivo imaging; computational imaging

(This special issue belongs to the Section Molecular Biophysics)

Molecular Mechanisms of Endothelial Dysfunction, Fifth Edition

edited by

Catherine Davis

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1051 | Submission Open

Keywords: vascular permeability; atherosclerosis; blood–brain barrier; endothelial adhesion molecules; vasodilation; thrombosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Global Challenges in Fungal Diseases: Pathogenesis, Host Interactions, and Novel Antifungal Approaches

edited by Samir Jawhara

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1009 | Submission Open

Keywords: Candida species; Aspergillus spp.; Mucorales; Fusarium spp.; multidrug-resistant fungi; immune response; opportunistic mycoses; host–pathogen interactions fungal cell wall glycans anti-fungal drugs

(This special issue belongs to the Section Molecular Microbiology)

Nanobiomaterials for Medical Research: From Molecular Mechanisms to Clinical Translation

edited by

Carmen Curutiu

Alina Maria Holban

and

Florin Iordache

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1003 | Submission Open

Keywords: nanomaterials; biopolymers; medical research; chronic diseases; molecular mechanisms

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Mechanisms, Biomarkers, and Therapeutic Targets in Heart Failure

edited by Celestino Sardu

submission deadline 31 Aug 2026 | 1 articles | Viewed by 951 | Submission Open

Keywords: heart failure; molecular mechanisms; ventricular remodeling; biomarkers; myocardial fibrosis; inflammation; oxidative stress; non-coding RNAs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Research in Cerebellar Development and Disease

edited by Maryam Rahimi-Balaei

submission deadline 31 Aug 2026 | 1 articles | Viewed by 945 | Submission Open

Keywords: cerebellar development; cerebellum; neural development; neurogenesis; neuronal migration; cerebellar malformations

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Plant Bioactive Compounds

edited by

Tarek Alshaal

submission deadline 31 Aug 2026 | 1 articles | Viewed by 919 | Submission Open

Keywords: plant bioactive compounds; phytochemicals; polyphenols; flavonoids; terpenoids; alkaloids; antioxidants; anti-inflammatory activity; molecular mechanisms; signaling pathways; gut microbiota; bioavailability; nutraceuticals; functional foods; phytochemistry; omics technologies; structure–activity relationship

(This special issue belongs to the Section Molecular Plant Sciences)

Multi-Omics Research in Oncology

edited by

Wenchao Gu

submission deadline 31 Aug 2026 | 1 articles | Viewed by 881 | Submission Open

Keywords: multi-omics; cancer genomics; transcriptomics; single-cell sequencing; spatial omics; machine learning; artificial intelligence; biomarker discovery

(This special issue belongs to the Section Molecular Oncology)

Current Research Trends on Enzyme Structure, Dynamics, and Mechanisms of Action

edited by

Amarendra Nath Maity

submission deadline 31 Aug 2026 | 1 articles | Viewed by 862 | Submission Open

Keywords: enzyme mechanism; enzyme dynamics; metalloenzymes; cofactor; X-ray crystallography; cryo-electron microscopy; QM/MM; DFT; EPR; drug target

(This special issue belongs to the Section Biochemistry)

Oral and Esophageal Disorders: Molecular Induction/Promotion, Treatment, and Prevention

edited by

Takanobu Takata

submission deadline 31 Aug 2026 | 2 articles | Viewed by 854 | Submission Open

Keywords: oral disorders; esophageal disorders; stomatitis; esophagitis; lifestyle-related diseases; advanced glycation-end products; modern European medicines; traditional medicines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Compounds and Molecular Mechanisms in Health and Disease

edited by

Lucas Fornari Laurindo

and

Maria Angélica Miglino

submission deadline 31 Aug 2026 | Viewed by 836 | Submission Open

Keywords: bioactive compounds; molecular mechanisms; metabolic regulation; inflammation; oxidative stress; signaling pathways; chronic diseases; translational research; systems biology; disease prevention and therapy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Bacterial–Host Interactions: Molecular Mechanisms Governing Mutualism and Pathogenicity

edited by

Charles Viau

submission deadline 31 Aug 2026 | 1 articles | Viewed by 772 | Submission Open

Keywords: bacterial–host interactions; bacteria; host; host–microbe

(This special issue belongs to the Section Molecular Microbiology)

Medicinal Plants: Molecular Dissection of Active Compounds

edited by

Moxian Chen

and

Abazar Ghorbani

submission deadline 31 Aug 2026 | 1 articles | Viewed by 752 | Submission Open

Keywords: medicinal plants; active compounds; secondary metabolites; biosynthetic pathways; metabolic regulation; terpenoids; flavonoids; multi-omics; metabolic engineering; bioactivity

(This special issue belongs to the Section Molecular Plant Sciences)

Natural Products and Synthetic Molecules: Development of Novel Anticancer Drugs

edited by Vinícius D’Ávila Bitencourt Pascoal

submission deadline 31 Aug 2026 | Viewed by 727 | Submission Open

Keywords: anticancer drugs; natural products; synthetic molecules; bioactive compounds; molecular biology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Displaying special issue 251-300 on page 6 of 63.

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