Hydrogen Medicine: From Molecular Insights to Disease Intervention
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 29
Special Issue Editor
Interests: molecular hydrogen medicine; therapeutic medical gases; oxidative stress and antioxidants; signal transduction pathways; mitochondrial function and bioenergetics; ischemia-reperfusion injury; inflammation and cytokine regulation; metabolic syndrome and chronic diseases; hydrogen-based biomaterials and nanomedicine
Special Issue Information
Dear Colleagues,
Since the landmark discovery in 2007 that molecular hydrogen (H2) acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals, hydrogen medicine has emerged as a rapidly evolving field. Over the past decade, accumulating evidence from cell experiments, animal models, and clinical trials has demonstrated the therapeutic potential of hydrogen in a wide range of diseases, including ischemia–reperfusion injury, metabolic syndrome, neurodegenerative diseases, and cancer.
Despite these promising findings, the primary molecular targets of hydrogen and its precise mechanisms of action—such as its interaction with mitochondrial bioenergetics, regulation of gasotransmitters, and modulation of signal transduction pathways—remain to be fully elucidated. Bridging the gap between molecular insights and clinical intervention is critical for the translation of hydrogen medicine into standard clinical practice.
This Special Issue, "Hydrogen Medicine: From Molecular Insights to Disease Intervention," aims to gather the latest research advancing our understanding of hydrogen's biological effects. We welcome original research articles and comprehensive reviews covering topics including, but not limited to, the following:
- Molecular mechanisms of hydrogen action (e.g., mitochondrial function, Nrf2 pathway, anti-inflammation);
- Novel delivery systems for hydrogen (e.g., hydrogen-rich water, inhalation, nanomedicine);
- Therapeutic effects of hydrogen on acute and chronic diseases;
- Clinical trials and translational studies;
- Bioinformatics and multi-omics analysis in hydrogen medicine.
We look forward to receiving your contributions to this exciting field.
Dr. Fei Xie
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
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Keywords
- hydrogen medicine
- molecular hydrogen
- oxidative stress
- inflammation
- mitochondrial function
- gasotransmitters
- ischemia–reperfusion injury
- clinical trials
- signal transduction
- bioinformatics
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