Recent Research in Cerebellar Development and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 411
Special Issue Editor
Interests: cerebellar development and anomalies; neurogenesis; neural migration; neural differentiation; microRNA
Special Issue Information
Dear Colleagues,
Cerebellum is involved in numerous functions from motor control to cognition and emotion. Although the cerebellum occupies about ten percent of brain volume, it contains ~ 80% of the brain's neurons, organized into dense cellular layers. This neuron-rich region is formed by two distinct germinal zones for GABAergic and glutamatergic lineages. The entire process of neural development—including neurogenesis, neuronal migration, and differentiation/maturation—is under precise molecular control, involving tightly regulated signaling, transcription, and epigenetic mechanisms in the cerebellum. Cerebellar cytoarchitecture and compartmentalization are established from embryonic through postnatal stages. A wide variety of congenital anomalies can affect this delicate brain region and are associated with developmental disabilities. Several genes implicated in congenital human cerebellar malformations have been identified and studied in mouse models. Moreover, exposure to toxic substances has profound effects on the developing cerebellum, resulting in neural cell death. In this issue, complementary human and mouse studies work synergistically to advance our understanding of the mechanisms governing cerebellar development and disease.
Dr. Maryam Rahimi-Balaei
Guest Editor
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Keywords
- cerebellar development
- cerebellum
- neural development
- neurogenesis
- neuronal migration
- cerebellar malformations
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