Advances in Vascular Function, Senescence and Remodeling: A New Direction for Therapeutic Approach to Prevent CVDs
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 January 2026
Special Issue Editor
Interests: cardiovascular diseases; vascular aging; sirtuins; mitochondrial function; heart failure; ischemia reperfusion injury; cell senescence; endothelial biology; induced pluripotent stem cell biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Cardiovascular diseases still remain the leading cause of death worldwide. Sudden cardiac arrest, heart attack, and stroke are on the rise, often leading to unexpected fatalities even before medical attention can be provided. Chronic vascular dysfunction—characterized by sustained vascular inflammatory responses, endothelial cell senescence, remodeling, and vessel collapse or stiffening—can account for cardiovascular and cerebrovascular diseases. A deeper understanding of this area may offer insights into how these events occur. Key challenges we face include the discovery of novel pathways and small molecules that can effectively target them. Current therapeutic approaches have not been successful in preventing mortality or improving clinical outcomes in patients following cardiovascular events. This Special Issue is now accepting articles that focus on novel mechanisms and potential therapeutic strategies to prevent vascular disfunction, cellular senescence, vascular inflammation, and remodeling—processes that may underline the development of cardiovascular diseases.
Dr. Gautham Yepuri
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- vascular dysfunction
- senescence
- endothelial cells
- small molecules
- anti-aging
- cardiovascular diseases
- sudden death
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