Molecular Advances in Metabolic Bone Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 241
Special Issue Editor
Interests: metabolic bone disease; osteoporosis; molecular biology; bone cells; calciotropic factors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolic bone disorders (MBD) can affect anyone but are more likely to occur in certain individuals, such as those with advanced age, vitamin D deficiency, chronic oral glucocorticoid use, acute weight loss, inactivity and alcohol excess. However, this issue of the journal is focused on rare metabolic disease. This is diverse group of disorders and include Paget's disease of bone (PDB), tumour-induced osteomalacia, fibrous dysplasia, osteogenesis imperfecta (OI), X-linked hypophosphatemia, hypophosphatasia (ALPL) and osteopetrosis. Healthy bone has a finely balanced remodelling coupling of formation by osteoblasts and resorption by osteoclast, normal mineralisation process and bone matrix formation. MBD have shared pathological features in collagen organisation, excess or abnormal osteoid or excess microfractures due to poor bone microarchitecture.
Regarding MBD, genetic and locus heterogeneity in various disorders, such as OI, ALPL and hypophosphatemic rickets, remains a challenge in linking phenotypic manifestation with molecular and cellular biology. The underlying molecular mechanism of somatic mosaicism remains a mystery for segmental PDB and mosaic OI. A deeper understanding of molecular biology of BMD is critical for explaining unpredictable severity of the disorders, early diagnosis and pathway-targeted therapies, as well as for future gene-editing and miRNA therapies.
Dr. Harish K. Datta
Guest Editor
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Keywords
- metabolic bone disease
- bone cells
- rare diseases
- genetics
- molecular biology
- skeletal development disorders
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