Immune Regulatory Mechanisms in the Pathogenesis of Autoimmunity
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 1007
Editors
Interests: autoimmunity; regulatory mechanisms; atopic dermatitis; chronic spontaneous urticaria
Special Issues, Collections and Topics in MDPI journals
Interests: immune-mediated-inflammation; semaphorins; regulatory molecules; chronic spontaneous urticaria
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Immune-mediated diseases, specifically autoimmune, develop when regulatory mechanisms fail to maintain self-tolerance. Immune regulation is classically maintained by the proper function of T and B regulatory cells, which prevent immune inflammation and keep a normal balance between inflammatory and inhibitory cytokines. During the last decade, attention was switched towards the role of many membrane-bound regulatory molecules on both B and T regulatory cells, such as CD72, semaphorin3A (sema3A), PD1-PDL1 pairs, LAG3 and others. Moreover, soluble regulatory molecules such as sol CD72, sol sema3A, sol CTLA-4, sol LAG3 and others are intensively investigated, becoming a hot issue with the aim of obtaining a better understanding of their pathogenesis of autoimmunity. With respect to all of the above, new therapeutic approaches are introduced, aiming to target these molecules and achieve better outcomes for all immune-mediated diseases. In this Special Issue, we invite contributors to submit relevant original papers or reviews covering new aspects and highlighting new ideas to enhance our understanding of these regulatory molecules.
Prof. Dr. Elias Toubi
Prof. Dr. Vadasz Zahava
Guest Editors
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Keywords
- immune regulation
- soluble regulatory molecules
- autoimmunity
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