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Nanobiomaterials for Medical Research: From Molecular Mechanisms to Clinical Translation

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 988

Editors


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Guest Editor
Faculty of Biology, University of Bucharest, 030018 Bucharest, Romania
Interests: alternative antimicrobials; molecular microbiology; biofilm modulation; host–pathogen interactions; antibacterial nanoparticles
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine, 050097 Bucharest, Romania
Interests: cellular biology; tissue engineering; nanomaterials

Special Issue Information

Dear Colleagues,

Nanomaterials could be considered the new golden standard for the management of the most challenging diseases of the century, such as cancer and infections caused by resistant pathogens.  Infections caused by multi-drug-resistant bacteria in patients with chronic diseases have been associated with high mortality and morbidity. Patients with cancer, diabetes, metabolic disorders, chronic wounds, and others are at special risk of developing difficult-to-treat infections. Deciphering microbial resistance at the molecular level and regulating key mechanisms to limit the selection of resistant strains by nanotechnology is a promising direction towards the control of multiresistant bugs. On the other hand, nanotechnology has a great impact on the diagnosis and treatment of numerous chronic diseases, which puts patients at a special risk of developing communicable conditions. This Special Issue will focus on the latest discoveries of different types of nanomaterials or biopolymers, alone or functionalized with key drugs (anticancer substances, hormones, antibodies, antibiotics, small peptides, plant extracts, probiotics) that could make a difference in the management of chronic diseases at the molecular level.

Original research articles and reviews regarding latest (nano)materials design, drug targeting, cellular and molecular trafficking which could be translated into treatment methods; their properties, and new insight into their mechanism of action at cellular and molecular level are welcome.

The scope of this Special Issue includes, but is not limited to, the following topics:

  • Materials in infection control;
  • New design of smart materials;
  • Coatings for modulating cellular adherence;
  • Biofilm control;
  • Bioactive medical devices;
  • Nanotechnology in host–pathogen studies;
  • Materials and new technologies for wound healing;
  • Drug delivery;
  • Molecular mechanisms of nanoparticles;
  • Cellular trafficking of nanostructured drugs;
  • Nanoparticles for chronic diseases.

Dr. Carmen Curutiu
Dr. Alina Maria Holban
Dr. Florin Iordache
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • biopolymers
  • medical research
  • chronic diseases
  • molecular mechanisms

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Published Papers (1 paper)

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Research

21 pages, 4500 KB  
Article
3D Bioprinting of Blood Vessel Model for Improving Wound Healing
by Florin Iordache, Madalina Dulceanu, Alina Maria Holban, Alexandra Valentina Badaluta, Aurelia Magdalena Pisoschi, Bogdan Stefan Vasile, Bogdan Amuzescu and Carmen Curutiu
Int. J. Mol. Sci. 2026, 27(9), 4019; https://doi.org/10.3390/ijms27094019 - 30 Apr 2026
Cited by 1 | Viewed by 669
Abstract
Hydrogel-based stem cell therapy uses different stem cells and bioactive molecules for wound healing in the treatment of diabetes and chronic burn wounds by accelerating angiogenesis, collagen deposition, and inhibition of inflammatory responses. Artificial vessels have already been used for patients with cardiovascular [...] Read more.
Hydrogel-based stem cell therapy uses different stem cells and bioactive molecules for wound healing in the treatment of diabetes and chronic burn wounds by accelerating angiogenesis, collagen deposition, and inhibition of inflammatory responses. Artificial vessels have already been used for patients with cardiovascular diseases, but most of them are polymeric, which can cause thrombosis and restenosis. 3D bioprinting combines cells, growth factors, and biomaterials to create a setting in which cells grow and differentiate into native tissue-like structures. The current study aimed to create a model of blood vessels using collagen and hyaluronic acid hydrogel combined with endothelial and muscle progenitor cells derived from amniotic mesenchymal stem cells using 3D bioprinting. A computer-aided design (CAD) software was employed to create the 3D models of a blood vessel model and printed using a 3D bioprinter with two printheads: one with bioink encapsulating endothelial progenitor cells and the second with bioink encapsulating smooth muscle progenitor cells. The blood vessel constructs were characterized morphologically and structurally by Fourier Transform Infrared (FTIR) Spectroscopy, thermogravimetric analysis (TGA), Scanning Electron Microscopy (SEM), immunohistochemistry, water uptake, and enzymatic degradation. Viability, proliferation, oxidative stress, vascular endothelial growth factor (VEGF) and nitric oxide (NO) production were assessed to demonstrate the cytocompatibility of the blood vessel constructs. Our results showed that collagen–hyaluronic acid hydrogels embedded with stem cells can be used for vascular constructs, meeting the desired requirements of biocompatibility and accuracy in reproducing the model created in the CAD software v1.0. Full article
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