Metabolic Sensing and Adaptive Stress Responses in Aging and Chronic Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 951
Special Issue Editor
2. The School of Life Sciences, Manchester Metropolitan University, Manchester M1 5QA, UK
Interests: C-reactive protein; stem cell; drug delivery; neurodegenerative disease; stroke; autoimmune disease
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Special Issue Information
Dear Colleagues,
I am pleased to invite you to contribute to a forthcoming Special Series entitled “Metabolic Sensing and Adaptive Stress Responses in Aging and Chronic Disease”. This series will bring together leading and emerging research that explores how cells, tissues, and organ systems sense metabolic, mechanical, and redox cues to maintain resilience across the lifespan.
A growing body of evidence suggests that pathways involved in energy sensing, mitochondrial quality control, autophagy, and redox homeostasis are central determinants of healthy aging and protection against chronic non-communicable diseases. Physical exercise, in particular, has emerged as a powerful physiological stimulus capable of engaging these pathways in a coordinated manner, offering mechanistic insights that extend beyond traditional pharmacological approaches.
The purpose of this Special Series is to provide a platform for interdisciplinary work spanning molecular and cellular biology, physiology, translational medicine, and clinical research. We especially welcome contributions that elucidate how metabolic stress signaling and exercise-induced adaptations modulate aging trajectories, reduce chronic inflammation, and confer protection against cardiovascular, metabolic, neurodegenerative, and inflammatory diseases.
By integrating fundamental mechanisms with translational perspectives, this Special Issue will advance our understanding of metabolic plasticity and identify actionable strategies for promoting healthspan and disease resilience. I warmly encourage you to submit original research articles, reviews, and perspectives that align with these themes, and I look forward to receiving your contributions.
With kind regards,
Prof. Dr. Mark Slevin
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- metabolic sensing
- aging and healthspan
- exercise physiology
- AMPK–mTOR signaling
- autophagy and mitophagy
- redox biology
- mitochondrial quality control
- cellular stress adaptation
- chronic disease prevention
- inflammaging
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