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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Biology of Gynecologic Health and Disease

edited by Marcin Bobiński

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1171 | Submission Open

Keywords: molecular biomarkers; gynecologic endocrinology; gynecologic oncology; hypothalamic–pituitary–ovarian axis; ovarian reserve and reproductive aging

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanisms and Cellular Functions of Tubulin in Neuronal Health and Disease

edited by

Antonella Sferra

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1169 | Submission Open

Keywords: tubulin; microtubules; neurodegeneration; neuron; brain; neurodevelopment; motor proteins

(This special issue belongs to the Section Molecular Biology)

Advances in Cardiovascular Disease: Pathophysiology, Diagnosis, and Therapy

edited by Masaru Tanaka

submission deadline 31 Jan 2027 | 2 articles | Viewed by 1154 | Submission Open

Keywords: cardiovascular disease; endothelial dysfunction; vascular remodeling; inflammation; immunothrombosis; biomarkers; extracellular vesicles; mitochondrial dysfunction; cellular senescence; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Roadmap of the Human Epigenome: Insights from RNAs

edited by

Maria Samara

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1138 | Submission Open

Keywords: human epigenome; non-coding RNAs; RNA-mediated regulation; transcriptomics; diagnostics and therapeutic strategies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cancer, Chronic Disease and Health Equity: Translational Oncology in the Era of Multimorbidity and Systems Innovation

edited by

Giorgio Malpeli

, Kiven Erique Lukong and Marco Feligioni

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1135 | Submission Open

Keywords: molecular mechanisms in chronic diseases and cancer; cancer metabolism, inflammation, and systemic disease interactions; biomarker discovery in cancer and chronic diseases; biological mechanisms in cancer and chronic diseases; neuroimmune responses in cancer and chronic diseases; epigenetic events in cancer and chronic diseases; translational oncology and precision medicine; artificial intelligence and digital innovation in oncology and chronic disease care; cancer and cardiometabolic disease intersections; multimorbidity management strategies in oncology care; integrated screening, prevention, and survivorship models; implementation science in cancer and chronic disease care

(This special issue belongs to the Section Molecular Oncology)

Rheumatic Diseases: From Pathophysiology to Novel Therapeutic Approaches

edited by Namrata Singh

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1134 | Submission Open

Keywords: rheumatic diseases; disease mechanisms; treatment; long-term outcomes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Sphingolipids in Infections, Disorders and Diseases

edited by Elita Avota

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1132 | Submission Open

Keywords: sphingolipids; sphingolipid biosynthesis; sphingolipidoses; metabolic disorders; infections; lipidomics; sphingolipid targeting drugs

(This special issue belongs to the Section Biochemistry)

Unraveling Immunometabolism in Sepsis: From Cellular Reprogramming to Therapeutic Targets

edited by

Marcello Candelli

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1120 | Submission Open

Keywords: sepsis; immunometabolism; metabolic reprogramming; cellular bioenergetics; innate and adaptive immunity; mitochondrial dysfunction; inflammatory signaling; metabolic biomarkers; therapeutic modulation; host–pathogen interactions

(This special issue belongs to the Section Molecular Immunology)

mRNA Vaccines Against Viral Infectious Diseases: Progress and Prospects

edited by

Barbara Ridolfi

and Maria Teresa Maggiorella

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1086 | Submission Open

Keywords: viruses; mRNA vaccines; mRNA structure; mRNA platform technologies; lipid nanoparticle (LNP) delivery; immunization strategies; adjuvants; preclinical trials; clinical trials; germline-targeting; broadly neutralizing antibodies; humoral immune response; cellular immune response; host–vaccine interactions

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms of Chronic Lung Diseases

edited by

Ramcés Falfán-Valencia

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1086 | Submission Open

Keywords: interstitial lung diseases; chronic respiratory diseases; genetic susceptibility; genomic; cytokine networks; metalloproteinases; inflammasome; inflammatory cytokines; telomere length

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insight into Biomaterials for Tissue Engineering and Regenerative Medicine

edited by

Diana Torge

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1085 | Submission Open

Keywords: biomaterials; tissue regeneration; regenerative medicine; bone regeneration; periodontal disease; morphology; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Emerging Topics in Polymeric Nanoparticles

edited by

Andrei Honciuc

and

Mirela Honciuc

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1065 | Submission Open

Keywords: polymeric nanoparticles; nanostructured materials; functional polymers; Janus particles; self-assembly; drug delivery; environmental remediation; microplastics; biodegradability; nanomedicine; green synthesis; adsorbents; life cycle assessment; surface functionalization; smart materials; biocompatibility; environmental impact; bioaccumulation; responsive polymers; hybrid nanomaterials

(This special issue belongs to the Section Macromolecules)

Current Molecular Advances in Apoptosis

edited by

Mariarosaria Boccellino

and

Davide Viggiano

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1056 | Submission Open

Keywords: apoptosis; glomerulonephritis; aging; caspase; endonuclease; DNA; cytokeratin

(This special issue belongs to the Section Biochemistry)

Novel Therapeutic Strategies and Targets in Rheumatoid Arthritis

edited by David Fox and

James J. Moon

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1039 | Submission Open

Keywords: RA; synovium; FLS; synovial fluid; microbiome; autoimmunity; DMARD; joint inflammation; joint damage; nanoparticle

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Immune Responses, Viral Infection and Neurodegenerative Diseases

edited by

Xin Dang

and Barbara Hanson

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1030 | Submission Open

Keywords: immune response; innate immunity; viral neuropathogenesis; viral biomarker; AD; PD; neurodegenerative diseases

(This special issue belongs to the Section Molecular Immunology)

New Molecular Research on High-Fat Diet on Human Health and Disease

edited by

Berta Alejandra Espinosa Escalona

submission deadline 31 Jan 2027 | 1 articles | Viewed by 999 | Submission Open

Keywords: obesity; diet-induced obesity; antioxidants

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms of Early-Life Environmental Effects on Brain Development

edited by

Sarah E. Latchney

submission deadline 31 Jan 2027 | 1 articles | Viewed by 986 | Submission Open

Keywords: early-life environment; brain development; neurodevelopmental programming; environmental exposures; developmental neurotoxicology; gene–environment interactions; maternal health; epigenetic regulation; neuroimmune interactions; endocrine disruption

(This special issue belongs to the Section Molecular Neurobiology)

Computational Approaches in Biomedicine: Innovations and Insights

edited by

Carlos Leon

submission deadline 31 Jan 2027 | Viewed by 983 | Submission Open

Keywords: computational biomedicine; artificial intelligence; machine learning; omic technologies; system biology; medical imaging; structural biology; drug discovery

(This special issue belongs to the Section Molecular Informatics)

Genome Editing and Biotechnology in Fruit Improvement

edited by Hongxia Miao

submission deadline 31 Jan 2027 | 1 articles | Viewed by 982 | Submission Open

Keywords: fruit improvement; horticultural crops; genome editing; biotechnology; molecular biology; plant genetics

(This special issue belongs to the Section Molecular Plant Sciences)

Vitamin D Metabolism and Molecular Signaling in Human Diseases

edited by

Anna Cieslinska

submission deadline 31 Jan 2027 | 1 articles | Viewed by 925 | Submission Open

Keywords: vitamin D; vitamin D metabolism; molecular signaling; genomic and non-genomic pathways; epigenetics; immune regulation; inflammation; metabolic disorders; autoimmune diseases; cancer biology; gut microbiota; genetic polymorphisms; precision medicine

(This special issue belongs to the Section Molecular Biology)

Chronic Stress, Neuroinflammation and Pain: Molecular Mechanisms, Biomarkers and Precision Therapies

edited by Nebojsa Knezevic and

Aleksandar Sič

submission deadline 31 Jan 2027 | Viewed by 922 | Submission Open

Keywords: chronic stress; chronic pain; neuroinflammation; biomarkers; pain mechanisms; neuropathic pain; low back pain; neuroimmune interactions; precision medicine; personalized therapy; pain phenotyping; translational research; mental health; neurobiology; pain management; inflammatory pathways; stress biomarkers; central sensitization

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Alternative Splicing, Isoform Diversity, and Cell Function

edited by

Tetiana Zaǐchuk

submission deadline 31 Jan 2027 | 1 articles | Viewed by 907 | Submission Open

Keywords: alternative splicing; isoform diversity; RNA-binding proteins; splicing regulation; cellular stress response; proteomic complexity; splicing in disease; computational splicing analysis

(This special issue belongs to the Section Molecular Biology)

Retinal Degeneration: From Pathophysiology to Therapeutic Approaches—4th Edition

edited by

Jan Wijnholds

submission deadline 31 Jan 2027 | 1 articles | Viewed by 897 | Submission Open

Keywords: hereditary retinal disease; retinal inflammation; retinal gene augmentation, editing, optogenetics and splice modulation therapy; natural history studies of the retina; human iPSC-derived retinal organoids and retinal pigment epithelium; retinal iPSC-derived cell therapy; retinal pathology; pre- and clinical gene therapy; animal models for retinal dystrophy; retinal imaging; retina-on-a-chip

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Horizons in Pain Therapeutics

edited by Alaa Abd-Elsayed

submission deadline 31 Jan 2027 | 1 articles | Viewed by 890 | Submission Open

Keywords: spinal cord stimulation; peripheral nerve stimulation; stem cell therapy; platelet-rich plasma (PRP) injections; chronic pain management; interventional pain procedure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Advances in Targeted Molecular Therapies for Genetic Disease

edited by Viorica-Elena Rădoi

submission deadline 31 Jan 2027 | 1 articles | Viewed by 879 | Submission Open

Keywords: genetic diseases; precision medicine; gene editing; RNA-based therapeutics; genomic profiling; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Anticancer Drug Discovery: Design, Synthesis and Molecular Insights

edited by

Michele De Franco

submission deadline 31 Jan 2027 | 2 articles | Viewed by 877 | Submission Open

Keywords: anticancer agents; drug design; drug synthesis; structure-activity relationship (SAR); target interactions; medicinal chemistry; lead optimization; targeted therapy; bioactive compounds

(This special issue belongs to the Section Molecular Pharmacology)

Green Gold: Microalgae as a Sustainable Source of Nutrients and Bioactive Compounds

edited by

Blanca Hernández-Ledesma

and Pilar Gómez-Cortés

submission deadline 31 Jan 2027 | 1 articles | Viewed by 876 | Submission Open

Keywords: microalgae; sustainable nutrition; bioactive compounds; functional foods; nutraceuticals; alternative proteins; phycochemistry; circular bioeconomy; biorefinery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Surfactants: Design, Synthesis and Properties

edited by

Joanna Krawczyk

submission deadline 31 Jan 2027 | 1 articles | Viewed by 868 | Submission Open

Keywords: design and synthesis of surfactants; adsorption and aggregation properties of surfactants; behavior of surfactants at different interfaces; application of biosurfactants and specialist surfactants (industry, agriculture, medicine, pharmacy)

(This special issue belongs to the Section Materials Science)

Molecular Research and Insights in Rapeseed Abiotic Stress

edited by

Ahsan Ayyaz

submission deadline 31 Jan 2027 | 1 articles | Viewed by 849 | Submission Open

Keywords: rapeseed (Brassica napus); abiotic stress; drought tolerance; salinity stress; heavy metal toxicity; molecular mechanisms; stress signaling; omics (transcriptomics, proteomics, metabolomics); molecular breeding; CRISPR-Cas9; stress-responsive genes; hormone cross-talk; epigenetic regulation; stress resilience

(This special issue belongs to the Section Molecular Plant Sciences)

Functional Materials for Biomedical Applications and Uses

edited by

Magdalena Laskowska

submission deadline 31 Jan 2027 | 1 articles | Viewed by 828 | Submission Open

Keywords: functional materials; nanomaterials; biomedical applications; molecular engineering

(This special issue belongs to the Section Materials Science)

Supramolecular Liquid Crystal Compounds—from Molecular Design to Functional Materials

edited by

Katarzyna Merkel

submission deadline 31 Jan 2027 | Viewed by 821 | Submission Open

Keywords: supramolecular; self-assembled; liquid crystal; hydrogen bonding

(This special issue belongs to the Section Materials Science)

Research Progress on Photosensitizers and Photodynamic Therapy

edited by

Michal Heger

submission deadline 31 Jan 2027 | Viewed by 803 | Submission Open

Keywords: photodynamic therapy; photosensitizers; tumor microenvironment; nanotechnology; immunotherapy; targeted drug delivery; reactive oxygen species; hypoxia; combination therapy; molecular mechanisms

(This special issue belongs to the Section Biochemistry)

Mesenchymal Stem Cell-Derived Extracellular Vesicles as Therapeutic Tools in Chronic Diseases

edited by

Elena Grossini

submission deadline 31 Jan 2027 | 1 articles | Viewed by 788 | Submission Open

Keywords: cell-free therapy; exosomes; immunomodulation; molecular mechanisms; regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Small Molecules in Tissue Repair and Regeneration

edited by

Ildiko Bock-Marquette

submission deadline 31 Jan 2027 | 1 articles | Viewed by 778 | Submission Open

Keywords: small molecules; organ and tissue regeneration; development; aging

(This special issue belongs to the Section Molecular Biology)

Vector–Pathogen–Host Interaction, Vaccines and Immunobiologicals

edited by Carlo José Freire Oliveira and

Marcos Vinícius Da Silva

submission deadline 31 Jan 2027 | 1 articles | Viewed by 775 | Submission Open

Keywords: host–pathogen–vector interactions; active biomolecules; immunomodulation; vaccines; binding molecules; immunobiologicals

(This special issue belongs to the Section Molecular Immunology)

Molecular and Systems Mechanisms of Neural Circuit Function and Plasticity

edited by

Hyunjung Oh

submission deadline 31 Jan 2027 | 1 articles | Viewed by 754 | Submission Open

Keywords: neural circuits; neuroplasticity; synaptic organization; brain aging; mood disorders; neurodegenerative disorders; cognitive function

(This special issue belongs to the Section Molecular Neurobiology)

Exploring the Crossroads of Autoimmunity, Inflammatory Diseases, and Cancer

edited by

Xuming Mao

submission deadline 31 Jan 2027 | 1 articles | Viewed by 752 | Submission Open

Keywords: autoimmune disorders; tumor microenvironment; chronic inflammation; immune checkpoint inhibitors; machine learning; epidemiology

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights into Stroke: Biomarkers and Mechanisms

edited by Jae Sang Oh

submission deadline 31 Jan 2027 | 1 articles | Viewed by 711 | Submission Open

Keywords: stroke; glymphatic system; biomarkers; human-derived specimens; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Molecular Basis of Vascular Pathology: 2nd Edition

edited by

Jolanta Neubauer-Geryk

submission deadline 31 Jan 2027 | 1 articles | Viewed by 709 | Submission Open

Keywords: vascular pathologies; blood vessels; dysfunction; vascular damage; blood flow; biomarkers; biomolecules; cytokines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapeutic Innovations in Urological Cancers

edited by Michele Marchioni,

Luigi Schips

and Angelo Cafarelli

submission deadline 31 Jan 2027 | 1 articles | Viewed by 686 | Submission Open

Keywords: urological cancers; molecular pathways; precision oncology; biomarkers; targeted therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Mechanisms and Therapeutics in Neurological Diseases—5th Edition

edited by

Barbara Mroczko

submission deadline 31 Jan 2027 | 1 articles | Viewed by 664 | Submission Open

Keywords: neurodegeneration; neuroinflammation; neurodegenerative diseases; neurodevelopmental disorders; tumor markers; specific proteins

(This special issue belongs to the Section Molecular Neurobiology)

Identification of Molecular Biomarkers Through Digital Pathology

edited by

Rafael Parra-Medina

submission deadline 31 Jan 2027 | 1 articles | Viewed by 656 | Submission Open

Keywords: digital pathology; molecular biomarkers; computational pathology; artificial intelligence; deep learning; spatial biology; multi-omics integration; tumor microenvironment; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Agricultural Hydrology: Plant-Soil-Water Interactions

edited by

Muhammad Bilal Khan

submission deadline 31 Jan 2027 | Viewed by 655 | Submission Open

Keywords: soil–plant–water system; agricultural hydrology; water-use efficiency; root water uptake; rhizosphere interactions; biogeochemical cycling; ecosystem functioning; climate change impacts; wastewater treatment

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Computational Drug Design and Molecular Modeling

edited by Ana C Stucki-Mafud

submission deadline 31 Jan 2027 | Viewed by 624 | Submission Open

Keywords: preclinical phase of drug development; computer-aided drug design; artificial intelligence; machine learning; deep learning; structure-based drug design; ligand-based drug design; virtual screening; pharmacophore modeling; molecular modeling

(This special issue belongs to the Section Molecular Informatics)

Aptamers in Cancer Therapy: Mechanisms, Applications, and Translational Perspectives

edited by

Gabor István Csonka

submission deadline 31 Jan 2027 | Viewed by 613 | Submission Open

Keywords: aptamers; targeted drug delivery; cancer immunotherapy; molecular imaging; biomarkers; precision oncology; SELEX; theranostics; translational oncology; mechanistic insights

(This special issue belongs to the Section Molecular Oncology)

Diverse Molecular Mechanisms of Berberine Action—Identifying Potential Targets and Therapeutic Potential

edited by

Dariusz Szukiewicz

submission deadline 31 Jan 2027 | 1 articles | Viewed by 605 | Submission Open

Keywords: berberine; isoquinoline alkaloid; AMPK activator; natural compound; metabolic syndrome; wieight loss; antioxidant effects; anti-inflammatory effects; antitumor activity; neuroprotection

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Valorization of Lignocellulosic Biomass: 2nd Edition

edited by

Haishun Du

submission deadline 31 Jan 2027 | Viewed by 596 | Submission Open

Keywords: lignocellulosic biomass; biorefinery; biomass conversion; bioenergy; biofuels; bioproducts; platform chemicals; cellulose nanomaterials; lignin nanoparticles; functional materials

(This special issue belongs to the Section Materials Science)

Emerging Roles of Extracellular Vesicles in Neurological Diseases

edited by Anudeep Yekula

submission deadline 31 Jan 2027 | Viewed by 585 | Submission Open

Keywords: extracellular vesicles; exosomes; neurological diseases; liquid biopsy; neurodegeneration; neuro-oncology; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Cancer Drugs That Target Epigenetic Processes

edited by Eileen Brantley

submission deadline 31 Jan 2027 | 1 articles | Viewed by 582 | Submission Open

Keywords: histone modifications; non-coding RNA; DNA methylation; cancer agents

(This special issue belongs to the Section Molecular Oncology)

Nanoparticles in Nanobiotechnology and Nanomedicine: 3rd Edition

edited by

Costica Caizer

submission deadline 31 Jan 2027 | Viewed by 577 | Submission Open

Keywords: nanoparticles; properties of nanoparticles; methods of obtaining nanoparticles; characterization techniques; theoretical models; computational simulation; applications in nanomedicine; applications in nanobiotechnology

(This special issue belongs to the Section Molecular Nanoscience)

Displaying special issue 2451-2500 on page 50 of 63.

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