Cardiovascular–Cerebrovascular Remodeling and Neuropsychiatric Conditions: Endothelium, Immunothrombosis, Microbiome Metabolites, Epigenetic Clocks
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 32
Special Issue Editor
Interests: depression; anxiety; dementia; pain; comorbidity; translational research
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue focuses on shared, multi-scale biology linking cardiovascular disease (CVD), cerebrovascular disease (including stroke), and neuropsychiatric conditions (notably depression and anxiety). We invite studies using single-cell and spatial multi-omics to resolve neurovascular and cardiac remodeling, vascular niche dynamics, and intercellular signaling across brain–heart axes. We especially welcome work on extracellular vesicles (EVs) as biomarkers and therapeutic carriers, including strategies that enhance blood–brain barrier (BBB) transport and improve post-stroke repair. Another priority is the interface of immunothrombosis, inflammation, and endothelial dysfunction as a mechanistic bridge from vascular injury to mood and cognitive outcomes. Submissions addressing gut microbiome–derived metabolites shaping cardiometabolic risk, cerebrovascular vulnerability, and anxiety-related phenotypes are encouraged. Finally, we seek mechanistic and translational manuscripts on mitochondrial stress, cellular senescence, and epigenetic clocks as drivers of vascular aging, cerebrovascular injury, cognitive decline, and neuropsychiatric trajectories. We welcome original research, computational/atlas resources, methods, and state-of-the-art reviews.
Dr. Masaru Tanaka
Guest Editor
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Keywords
- cardiovascular diseases
- cerebrovascular disorders
- stroke
- depressive disorder
- anxiety disorders
- single-cell analysis
- spatial transcriptomics
- extracellular vesicles
- blood–brain barrier
- immunothrombosis
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