Current Molecular Advances in Apoptosis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 21
Special Issue Editors
Interests: endometrium; pregnancy
Interests: nephrology; chaotic systems
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Special Issue Information
Dear Colleagues,
Apoptosis is a vital mechanism for maintaining tissue integrity, immune balance, and proper development. Core apoptotic components include caspases, mitochondrial cytochrome c release, and chromatin condensation. However, recent studies highlight caspase-independent pathways involving apoptosis-inducing factor (AIF) and endonuclease G. Circulating biomarkers like cell-free DNA and cytokeratin-18 now allow the better monitoring of apoptotic activity in vivo. Apoptosis dysregulation is linked not only to cancer, neurodegeneration, and glomerulonephritis, but also to aging. This Special Issue explores apoptosis within a broader context of regulated cell death, including necroptosis, ferroptosis, pyroptosis, and NETosis, revealing their interconnected roles in inflammation and disease. A particularly intriguing feature of apoptosis is how DNA cleavage by CAD (Caspase-Activated DNase) induces unique chromatin condensation, suggesting that DNA length may physically restrict compaction. By addressing emerging molecular pathways, death modalities, and diagnostic tools, this Special Issue aims to foster innovative approaches to target apoptosis and related mechanisms for therapeutic benefit.
Dr. Mariarosaria Boccellino
Dr. Davide Viggiano
Guest Editors
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Keywords
- apoptosis
- glomerulonephritis
- aging
- caspase
- endonuclease
- DNA
- cytokeratin
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