Alternative Splicing, Isoform Diversity, and Cell Function
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 4
Special Issue Editor
Interests: apoptosis; epigenetics; DNA; tumor microenvironment
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Alternative splicing is a key mechanism that expands proteomic diversity and precisely regulates cellular functions in development, physiology, and disease. Isoform-specific regulation impacts nearly all aspects of cell biology, including organelle dynamics, signaling, stress responses, metabolism, and intercellular communication. This Special Issue seeks to highlight new advances in understanding how splicing-driven isoform diversity shapes molecular processes and cellular behavior.
We invite submissions of original research articles, comprehensive reviews, short communications, and methods papers from the molecular biology, cell biology, biochemistry, structural biology, computational biology, genetics, and biomedical research communities.
Topics of interest include, but are not limited to, the following:
- Mechanisms governing alternative splicing and the generation of isoforms;
- Isoform-specific functions, subcellular localization, and protein-protein interactions;
- Regulation of splicing by RNA-binding proteins and various RNA modifications;
- Dynamics of splicing during development, differentiation, and cellular transitions;
- Aberrant splicing implicated in disease (e.g., cancer, neurodegeneration, metabolic, and rare disorders);
- Splicing changes induced by cellular stress and subsequent adaptive responses;
- Integrative omics approaches for discovering and functionally annotating isoforms;
- Computational methods for predicting and modeling splicing decisions;
- Experimental technologies for the detection, quantification, and functional analysis of isoforms.
Dr. Tetiana Zaǐchuk
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- alternative splicing
- isoform diversity
- RNA-binding proteins
- splicing regulation
- cellular stress response
- proteomic complexity
- splicing in disease
- computational splicing analysis
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