Mesenchymal Stem Cell-Derived Extracellular Vesicles as Therapeutic Tools in Chronic Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 126
Special Issue Editor
Interests: oxidative stress; cardiac function; mitochondrial function; aging; nitric oxide; physiology; NAFLD; microvesicles
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Human Umbilical Cord Mesenchymal Stem Cell-derived Extracellular Vesicles (HUMSC-EVs) have emerged as a pivotal “cell-free” therapeutic strategy in regenerative medicine. These vesicles encapsulate a rich cargo of bioactive molecules, including microRNAs, messenger RNAs, proteins, and lipids, which facilitate intercellular communication and modulate the microenvironment of damaged tissues. Unlike cell-based therapies, HUMSC-EVs offer the advantages of low immunogenicity and reduced tumorigenic risk while retaining the regenerative properties of their parent cells.
In the pathophysiology of chronic diseases, sustained inflammation and oxidative stress play central roles in tissue deterioration. HUMSC-EVs have demonstrated the ability to intervene in these processes by regulating key molecular pathways involved in immunomodulation, apoptosis, angiogenesis, and extracellular matrix remodeling. Hence, understanding the specific molecular cargo and the downstream signaling cascades triggered by these EVs is essential for developing targeted treatments.
Despite the promising therapeutic data, many questions remain regarding the precise molecular interactions between HUMSC-EVs and target cells in specific chronic conditions, as well as the optimization of their cargo for enhanced efficacy. Increasing knowledge about these molecular mechanisms could be useful from the perspective of preventive medicine and novel therapeutic strategies. For the abovementioned reasons, this Special Issue aims to fill these gaps on the topic by collecting original research and comprehensive reviews.
Dr. Elena Grossini
Guest Editor
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Keywords
- cell-free therapy
- exosomes
- immunomodulation
- molecular mechanisms
- regeneration
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