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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Insights into Cardiomyopathy
edited by
submission deadline 20 Nov 2026 | Viewed by 369 | Submission Open
Keywords: cardiomyopathy; inflammation; molecular mechanisms; targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Drug Delivery for Human Diseases: From Basic Research to Clinical Applications
edited by
submission deadline 20 Nov 2026 | Viewed by 200 | Submission Open
Keywords: drug delivery systems; nanomedicine; targeted therapy; traditional medicine; translational pharmaceutical research
(This special issue belongs to the Section Molecular Pharmacology)
The Impact of the Exposome on Gut Health: Deciphering Molecular Mechanisms and Pathophysiological Pathways
edited by
submission deadline 20 Nov 2026 | Viewed by 190 | Submission Open
Keywords: exposome (internal & external); molecular gastroenterology; intestinal barrier function; gut-microbiota-host crosstalk; environmental toxicology; signal transduction pathways; nutritional epigenomics; metabolic dysregulation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Therapies of Colorectal Cancer: 5th Edition submission deadline 20 Nov 2026 | Viewed by 170 | Submission Open
Keywords: pancreatic cancer; metabolism; cellular plasticity; tumor microenvironment; target therapy
(This special issue belongs to the Section Molecular Oncology)
Latest Molecular Discoveries of Arthropod-Borne Viruses
edited by Henry Puerta-Guardo
submission deadline 20 Nov 2026 | Viewed by 158 | Submission Open
Keywords: arbovirus; whole genome sequencing; pathogenesis; transcriptomics; CRISPR-Cas9; in silico; antivirals; vaccines; diagnostics
(This special issue belongs to the Section Molecular Microbiology)
Advances in Olfactory Neurobiology, Adult Neurogenesis and Dopaminergic Neuron Research
edited by
submission deadline 20 Nov 2026 | Viewed by 133 | Submission Open
Keywords: olfaction; olfactory bulb; dopaminergic neurons; Parkinson’s disease; Alzheimer’s disease; adult neurogenesis; early biomarker; neurodegenerative disease; smell impairment; smell test
(This special issue belongs to the Section Molecular Neurobiology)
Role of MicroRNAs in Human Diseases: 2nd Edition
edited by
submission deadline 25 Nov 2026 | 10 articles | Viewed by 20163 | Submission Open
Keywords: microRNAs, miRNAs, miRs; preclinical models; target interaction; regulatory networks; oncology; cancer biology; cardiovascular disease; neurodegenerative conditions; diagnostic applications; therapeutic development and clinical trials
(This special issue belongs to the Section Molecular Genetics and Genomics)
Nutrition and Cardiovascular Development, from Fetal Origins to Adulthood
edited by
submission deadline 25 Nov 2026 | Viewed by 321 | Submission Open
Keywords: fetal programming; developmental origins of health and disease; maternal nutrition; placental function; offspring; cardiovascular function; cardiometabolic risk; cardio renal development; essential fatty acids; linoleic acid
(This special issue belongs to the Section Molecular Biology)
Novel Antiviral Agents: Challenges and Opportunities from Molecular Targeting to Validation submission deadline 25 Nov 2026 | Viewed by 209 | Submission Open
Keywords: antiviral agents; molecular targeting; virus–host interactions; drug repurposing; host-directed antivirals; combination therapy; antiviral resistance; translational virology
(This special issue belongs to the Section Molecular Pharmacology)
Advanced 3D-Bioprinting for Next-Generation In Vitro Models: Molecular and Technological Perspectives submission deadline 25 Nov 2026 | Viewed by 195 | Submission Open
Keywords: 3D bioprinting; in vitro models; biofabrication; bioinks; hydrogels; disease modeling; toxicology; drug screening; biomaterials; organ-on-a-chip
(This special issue belongs to the Section Macromolecules)
Nanomaterial: Synthesis and Application
edited by
submission deadline 25 Nov 2026 | Viewed by 176 | Submission Open
Keywords: nanomaterials; green synthesis; surface functionalization; nanoparticle engineering; drug delivery systems; energy storage; catalysis; environmental remediation; biocompatibility; molecular nanotechnology
(This special issue belongs to the Section Molecular Nanoscience)
Mitochondrial Functions and Dynamics
edited by
submission deadline 27 Nov 2026 | 4 articles | Viewed by 16646 | Submission Open
Keywords: bioenergetics; mitochondrial biogenesis; mitochondrial morphology; apoptosis; mitophagy; reactive oxygen species; calcium homeostasis; cardiovascular diseases; neurodegenerative diseases; in vitro, cellular, and animal models; myopathies; mitochondria and immune system
(This special issue belongs to the Section Molecular Biology)
Molecular Insight into Catalysis of Nanomaterials
edited by Dandan Liu
submission deadline 27 Nov 2026 | 3 articles | Viewed by 5113 | Submission Open
Keywords: nanomaterial catalyst; thermal catalysis; photocatalysis; electrocatalysis; DFT calculation
(This special issue belongs to the Section Molecular Nanoscience)
Mechanisms and Effects of Endocrine Disruptors and Environmental Contaminants on Human Health submission deadline 27 Nov 2026 | 3 articles | Viewed by 4747 | Submission Open
Keywords: environmental exposure; emerging compounds; human health; risk assessment; adverse outcome pathway; new approach methodologies; one health
(This special issue belongs to the Section Molecular Toxicology)
Recent Approaches for Wound Treatment: 3rd Edition submission deadline 27 Nov 2026 | 1 articles | Viewed by 3409 | Submission Open
Keywords: wound healing; inflammation; angiogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Insights into Buckwheat Reproductive Biology
edited by
submission deadline 27 Nov 2026 | 1 articles | Viewed by 2006 | Submission Open
Keywords: antioxidant properties; biotechnological methods; embryology; seed chemical composition; yield
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms of Various Diseases and Drugs Involved in Vascular Tone Regulation in Cardiovascular Disease
edited by
submission deadline 27 Nov 2026 | 1 articles | Viewed by 1908 | Submission Open
Keywords: vasoconstriction; vasodilation; calcium; protein kinase C; Rho-kinase; hypertension; nitric oxide
(This special issue belongs to the Section Molecular Biology)
Solid Tumours in Focus: Tissue Biomarkers and Spatial Technologies in Cancer Pathology
edited by Kathryn Pennel
submission deadline 27 Nov 2026 | 2 articles | Viewed by 1578 | Submission Open
Keywords: biomarkers; cancer pathology; spatial biology; molecular mechanisms; tumour microenvironment; cell signalling and communication
(This special issue belongs to the Section Molecular Oncology)
Tissue Engineering and Advanced Biomaterials for Regenerative Medicine submission deadline 27 Nov 2026 | 1 articles | Viewed by 1331 | Submission Open
Keywords: tissue engineering; regenerative medicine; drug delivery; bioengineering; angiogenesis
(This special issue belongs to the Section Molecular Biology)
Harnessing Natural Compounds to Combat Cancer and Metastasis
edited by
submission deadline 27 Nov 2026 | Viewed by 948 | Submission Open
Keywords: natural compounds; bioactive molecules; natural extracts; chemotherapy; immunomodulatory compounds; anti-metastatic compounds; anti-angiogenic compounds
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Targeting Receptor Tyrosine Kinases and Related Signalling Pathways in Cancer: Mechanisms, Resistance, and Therapeutic Advances submission deadline 27 Nov 2026 | 1 articles | Viewed by 929 | Submission Open
Keywords: tyrosine kinase receptors (TKRs); tyrosine kinase inhibitors (TKIs); cancer; therapeutic resistance/cancer drug resistance/chemotherapy resistance; signaling pathways; metastasis; combination therapy; targeted therapy; next-generation inhibitors; allosteric inhibitors; personalized medicine; tumor microenvironment; immune evasion; immunotherapy; crosstalk in cancer signaling; miRNAs; lncRNAs; cancer therapeutics; biomarkers
(This special issue belongs to the Section Molecular Oncology)
Cellular Plasticity in Cancer: Mechanisms, Measurement and Therapeutic Opportunities
edited by Costa Frangou and
submission deadline 27 Nov 2026 | 1 articles | Viewed by 921 | Submission Open
Keywords: cellular plasticity; cancer progression; EMT/MET; lineage infidelity; therapy-induced reprogramming; stem-like states; single-cell analysis; spatial transcriptomics; lineage tracing; computational modeling; biomarkers; therapeutic re-sistance; metastasis; solid tumors
(This special issue belongs to the Section Molecular Oncology)
New Advances in DNA Nanotechnology
edited by Zhaoqi Yang
submission deadline 27 Nov 2026 | Viewed by 646 | Submission Open
Keywords: DNA nanotechnology; DNA-based drug delivery; DNA cages and DNA polyhedra; DNA origami; DNA-based electronic circuits; DNA-based sensors; DNA-based catalysis; DNA-based data storage
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Targeting and Pharmacology of Neuroinflammation
edited by
submission deadline 27 Nov 2026 | Viewed by 604 | Submission Open
Keywords: glia-targeted therapeutics; neuroinflammation; CNS drug development; astrocyte; microglia; neurodegeneration; translational neuroscience; biomarkers; human genetics; cytokine signaling
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Research on Endocrine and Metabolic Diseases
edited by
submission deadline 27 Nov 2026 | Viewed by 338 | Submission Open
Keywords: systems biology; metabolomics; fluxomics; organoid models; epigenetic regulation; precision medicine; endocrine–metabolic crosstalk
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Nanocomplexes and Drug Delivery Systems for Cancer Therapy
edited by
submission deadline 27 Nov 2026 | Viewed by 332 | Submission Open
Keywords: nanocomplexes; drug delivery systems; cancer therapy; nanocarriers; stimuli-responsive systems; theranostics; biomolecules delivery; tumor microenvironment; personalized medicine; multidrug resistance
(This special issue belongs to the Section Molecular Nanoscience)
Current Research for Heart Disease Biology and Therapeutics: Fourth Edition
edited by Claudia Kusmic
submission deadline 29 Nov 2026 | 3 articles | Viewed by 2151 | Submission Open
Keywords: myocardial hypertrophy; cardiac remodeling; heart failure; drug therapy; molecular therapeutic targets; myocardial gene therapy; heart disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Ethylene Signaling in Plants: Molecular Mechanisms from Growth Regulation to Postharvest Biology submission deadline 29 Nov 2026 | Viewed by 320 | Submission Open
Keywords: ethylene signaling networks; ethylene in plant development and senescence; ethylene-responsive gene expression; ethylene control of senescence and ripening; ethylene in postharvest biology
(This special issue belongs to the Section Molecular Plant Sciences)
Viruses as Therapeutic Tools: Medical and Biotechnological Applications
edited by
submission deadline 30 Nov 2026 | 8 articles | Viewed by 28003 | Submission Open
Keywords: molecular virology; virus–host interactions; immunology; gene therapy vectors; vaccines; antivirals
(This special issue belongs to the Section Molecular Microbiology)
Antimicrobial and Antiviral Peptides: 2nd Edition
edited by
submission deadline 30 Nov 2026 | 5 articles | Viewed by 21700 | Submission Open
Keywords: antimicrobial peptides; antiviral peptides; peptide mining; molecular mechanism of biological activity; structure–activity relationship; molecular targets; in silico design; in vivo models; peptide delivery strategies; biomedical applications
(This special issue belongs to the Section Biochemistry)
Molecular Advances on Cannabinoid and Endocannabinoid Research, 3rd Edition submission deadline 30 Nov 2026 | 5 articles | Viewed by 17854 | Submission Open
Keywords: cannabinoid; endocannabinoid; cannabinoid receptor; endogenous cannabinoid; pharmacological research
(This special issue belongs to the Section Molecular Pharmacology)
Advances in Epigenetics of Mental Disorders
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 17806 | Submission Open
Keywords: mental disorders; epigenetic; epigenomic; gene–environment interactions
(This special issue belongs to the Section Molecular Neurobiology)
Lifestyle Interventions in MASLD: Molecular and Clinical Perspectives
edited by Muhammad Y. Sheikh
submission deadline 30 Nov 2026 | 1 articles | Viewed by 17711 | Submission Open
Keywords: NAFLD (nonalcoholic fatty liver disease); MASLD (metabolic syndrome-associated steatotic liver disease); metabolic syndrome; dyslipidemia; diabetes mellitus 2; hypertension; natural bioactive
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Studies in Aging, 2nd Edition
edited by
submission deadline 30 Nov 2026 | 8 articles | Viewed by 16994 | Submission Open
Keywords: senescence; active aging; sarcopenia; osteoporosis; oxidative stress; brain aging; cardiovascular aging
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms Linked to Exercise
edited by
submission deadline 30 Nov 2026 | 2 articles | Viewed by 15514 | Submission Open
Keywords: molecular mechanisms; exercise adaptations; translational health
(This special issue belongs to the Section Molecular Biology)
Natural Active Substances in Human Diseases
edited by
submission deadline 30 Nov 2026 | 4 articles | Viewed by 14733 | Submission Open
Keywords: natural active substances; bioactive compounds; molecular mechanisms; traditional medicine; metabolic disorders; inflammatory diseases; neurodegenerative diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Modulation of the Immune System and Oxidative Stress in Liver Illnesses
edited by and Dan Ionuț Gheonea
submission deadline 30 Nov 2026 | 2 articles | Viewed by 14387 | Submission Open
Keywords: oxidative stress; liver illnesses; immune system; inflammatory
(This special issue belongs to the Section Molecular Immunology)
New Insights in Biomarkers of Autoimmune and Autoinflammatory Diseases: 2nd Edition
edited by
submission deadline 30 Nov 2026 | 5 articles | Viewed by 14135 | Submission Open
Keywords: inflammaging; inflammasome; autoantibodies; free light chains; cytokines; receptor; signal transduction; innate immunity; adaptive immunity
(This special issue belongs to the Section Molecular Immunology)
Steatotic Liver Disease: From Bench to Bedside and Back
edited by
submission deadline 30 Nov 2026 | 2 articles | Viewed by 11945 | Submission Open
Keywords: MASLD; ALD; MetALD; fibrosis; hepatocellular carcinoma; molecular mechanisms; molecular markers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Vitamin D in Human Health and Diseases, 5th Edition submission deadline 30 Nov 2026 | 5 articles | Viewed by 11301 | Submission Open
Keywords: vitamin D; vitamin D receptor; calciferol; health; disease; inflammation; gene transcription; cell metabolism; differentiation; vitamin D deficiency; vitamin D supplementation
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Neurogenesis and Neurodegeneration: Insights into Regeneration and the Impact of Neurotrophins submission deadline 30 Nov 2026 | 4 articles | Viewed by 11270 | Submission Open
Keywords: neurogenesis; neurodegeneration and regeneration; neurotrophins; brain plasticity
(This special issue belongs to the Section Molecular Neurobiology)
Neurological Diseases: From Physiology to Therapy submission deadline 30 Nov 2026 | 2 articles | Viewed by 11006 | Submission Open
Keywords: neurophysiology; genetics; Alzheimer’s disease; neurological diseases; neurodegenerative diseases
(This special issue belongs to the Section Molecular Neurobiology)
Functional Food Ingredients in Immunity Improvement submission deadline 30 Nov 2026 | 1 articles | Viewed by 10958 | Submission Open
Keywords: functional food ingredients; bioactive compounds; health potentials; food processing and immunomodulation; green extraction techniques; molecular mechanisms; nutritional immunology; dietary intervention
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Roles of Diet and Nutrition in Metabolic Diseases: Advancements in Molecular Insights
edited by Ramos-López Omar
submission deadline 30 Nov 2026 | 6 articles | Viewed by 10505 | Submission Open
Keywords: diet; nutrition; metabolic diseases; obesity; genetics; microbiota; epigenetics; metabolomics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Multidrug Resistance in Cancer: Molecular Mechanisms and Therapeutic Challenges submission deadline 30 Nov 2026 | 3 articles | Viewed by 10406 | Submission Open
Keywords: cancer therapy; MultiDrug Resistance (MDR); Pgp; efflux pumps; tumor microenvironment; anticancer drug target; combination therapy; novel anticancer agents
(This special issue belongs to the Section Molecular Biology)
Molecular Diagnosis and Treatment in Cardiovascular Diseases
edited by Calogera Pisano, and Giuseppe Raffa
submission deadline 30 Nov 2026 | 4 articles | Viewed by 10342 | Submission Open
Keywords: cardiac diseases; molecular diagnosis; aortopathy; aneurysm; dissection; heart failure
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Focus on Endocrine and Metabolic Research Priorities in PCOS/PMOS
edited by
submission deadline 30 Nov 2026 | 3 articles | Viewed by 10260 | Submission Open
Keywords: polycystic ovary syndrome; metabolism; insulin resistance; inflammation; hyperandrogenism
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
CRISPR/Cas Systems and Genome Editing—3rd Edition
edited by
submission deadline 30 Nov 2026 | 6 articles | Viewed by 9551 | Submission Open
Keywords: CRISPR/Cas; bacterial argonauts; transcription regulation; genome editing; genome editing tools
(This special issue belongs to the Section Molecular Genetics and Genomics)
Recent Advances in Urological Cancer
edited by Andrea Zivi and
submission deadline 30 Nov 2026 | 1 articles | Viewed by 9288 | Submission Open
Keywords: genitourinary oncology; urologic surgery; urologic radiotherapy innovations; translational research; emerging therapies
(This special issue belongs to the Section Molecular Oncology)
Plant Physiology and Molecular Nutrition: 2nd Edition
edited by and
submission deadline 30 Nov 2026 | 6 articles | Viewed by 8886 | Submission Open
Keywords: plant nutritional physiology; nutrient signaling; phytohormones; gene regulation network; environment and nutrition crosstalk
(This special issue belongs to the Section Molecular Plant Sciences)
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