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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Bioinspired and Emerging Functionalized Nanostructures for Precision Drug Delivery

edited by

Adelina-Gabriela Niculescu

and

Alexandra Catalina Birca

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1080 | Submission Open

Keywords: nanostructured materials; nanobiomaterials; nanocomposites; drug delivery systems; targeted therapies; controlled release; responsive functionalities; theranostics; biomedical applications; therapeutic innovations; bioinspired nanostructures; personalized medicine

(This special issue belongs to the Section Molecular Nanoscience)

Preimplantation Genetic Testing in Assisted Reproductive Technologies

edited by

Sung Tae Kim

submission deadline 20 Apr 2026 | Viewed by 1077 | Submission Open

Keywords: preimplantation genetic testing; embryo selection; in vitro fertilization; infertility; implantation failure; miscarriage; mosaicism; segmental aneuploidy; non-invasive technology

(This special issue belongs to the Section Molecular Genetics and Genomics)

Targeting Cancer Metabolism: From Mechanism to Therapies

edited by

Zisis Kozlakidis

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1076 | Submission Open

Keywords: cancer metabolism; metabolic alterations; Warburg effect; metabolic reprogramming; metabolic disorder; mitochondrial dysfunction; mitochondrial dynamics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Molecular Mechanism in Infertility

edited by

Antonio Simone Laganà

and Andrea Etrusco

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1056 | Submission Open

Keywords: infertility; molecular mechanisms; reproductive biology; genomics; epigenetics; biomarkers; assisted reproductive technologies; transcriptomics; proteomics; environmental factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Sex and Gender Medicine—Physiology: A New Horizon in Human Physiology

edited by

Rosanna Mallamaci

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1055 | Submission Open

Keywords: sex and gender; personalized medicine; sex-specific evidence; sex-specific differences

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Genotypes and Experimental Advances in Xenotransplantation

edited by Konrad Fischer

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1050 | Submission Open

Keywords: xenotransplantation; genetic engineering; preclinical models; genetically modified donor organs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hemolytic Anemia: From Molecular Mechanisms to Therapeutic Exploitation

edited by Joan-Lluis Vives-Corrons

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1030 | Submission Open

Keywords: hemolytic anemias; red blood cells; sickle cell disease; targeted therapies; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research and Recent Advances of Antimicrobials

edited by

Már Másson

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1028 | Submission Open

Keywords: antibiotic; antibacterial; antifungal; antiviral; chemical synthesis; drug discovery; natural products; small molecules; peptides; proteins; oligosaccharides; polysaccharides; drug delivery; nanoparticles; solutions; gels; formulation; nanoparticles; materials; coat-ings; drug release; structure– activity; mechanism of action; clinical application; veterinary applications; agricultural applications; food preservation

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanism of Sympathetic Nerves in Cardiovascular Diseases and Cancer

edited by

Yutang Wang

submission deadline 20 Apr 2026 | Viewed by 1018 | Submission Open

Keywords: sympathetic nerve activity; adrenergic receptors; renal denervation; heart disease; stroke; atherosclerosis; hypertension; diabetes; metabolic syndrome; cancer

(This special issue belongs to the Section Molecular Neurobiology)

The Role of Endocrine Disruptors in Immune Diseases

edited by

Eui-Bae Jeung

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1014 | Submission Open

Keywords: endocrine disruptors; immune disease; cytokine signaling; autoimmunity; immunotoxicity; epigenetic modulation; hormone receptors; inflammation; environmental toxicology; EDC exposure

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Insights in Metabolomics: Chromatography and Mass Spectrometry Applications in Cancer Research

edited by

Catarina Luís

and

Rosa Perestrelo

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1013 | Submission Open

Keywords: metabolomics; chromatography; mass spectrometry; molecular oncology; cancer pathways; precision medicine

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Artificial Intelligence in Molecular Biomarker Screening

edited by

Tony Hsiu-Hsi Chen

submission deadline 20 Apr 2026 | 1 articles | Viewed by 968 | Submission Open

Keywords: molecular biomarkers; imaging biomarkers; screening; artificial intelligence; metaverse

(This special issue belongs to the Section Molecular Informatics)

Chemical Elicitors and Microbial Metabolites: Synergistic Mechanisms in Plant Systemic Resistance Induction

edited by Heewan Kang

submission deadline 20 Apr 2026 | 1 articles | Viewed by 960 | Submission Open

Keywords: chemical elicitors; Bacillus spp.; microbial metabolites; amino acids; defense induction; resistance mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Cellular and Molecular Biology of Cardiac Hypertrophy and Heart Failure: Pathogenesis, Diagnostics and Treatment—2nd Edition

edited by

Morris Karmazyn

submission deadline 20 Apr 2026 | 1 articles | Viewed by 871 | Submission Open

Keywords: cardiac hypertrophy; myocardial remodelling; heart failure; cellular mechanisms; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Multidrug Resistance in Cancer: Molecular Mechanisms and Therapeutic Challenges

edited by

Odília Queirós

and

Patrícia M. A. Silva

submission deadline 20 Apr 2026 | 1 articles | Viewed by 866 | Submission Open

Keywords: cancer therapy; MultiDrug Resistance (MDR); Pgp; efflux pumps; tumor microenvironment; anticancer drug target; combination therapy; novel anticancer agents

(This special issue belongs to the Section Molecular Biology)

Application and Molecular Mechanisms of Microwaves for Materials Processing

edited by

Valentin Craciun

submission deadline 20 Apr 2026 | 1 articles | Viewed by 854 | Submission Open

Keywords: microwaves; non-ionizing radiation; molecular materials characterizations; molecular materials synthesis; microwave processing and engineering

(This special issue belongs to the Section Materials Science)

Advanced Plant Molecular Responses to Abiotic Stresses: 2nd Edition

edited by

Dong-Gwan Kim

submission deadline 20 Apr 2026 | 1 articles | Viewed by 832 | Submission Open

Keywords: abiotic stress responses (heat; drought; salinity; nutrient deficiency; oxygen quality; flooding; light; etc.); genetically modified plants; CRISPR/Cas-mediated stress overcome; microplastic/nanoparticle stresses; bioinformatic studies; miRNAs and other noncoding RNAs involved in abiotic stresses in plants; secondary metabolite synthesis

(This special issue belongs to the Section Molecular Plant Sciences)

Antimicrobial Agents: Natural Products or Synthetic Compounds 2nd Edition

edited by

Anna Duda-Madej

submission deadline 20 Apr 2026 | 1 articles | Viewed by 826 | Submission Open

Keywords: multidrug resistance; natural antimicrobial agents; synthetic antimicrobial compounds; combination therapy; severe infectious diseases

(This special issue belongs to the Section Molecular Microbiology)

Immune Cell Therapy and Genome Engineering

edited by

Kieu C. D. Nguyễn

submission deadline 20 Apr 2026 | 1 articles | Viewed by 799 | Submission Open

Keywords: immune cell therapies; regenerative therapy; gene editing technologies; epigenetic modulation; precision medicine; personalized therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular Mechanisms of Neurodegeneration and Neuroinflammation

edited by Marika Lanza and

Giovanna Casili

submission deadline 20 Apr 2026 | 1 articles | Viewed by 785 | Submission Open

Keywords: neuroinflammation; neurodegeneration; mitochondrial dysfunction; oxidative stress; metabolomics; therapeutic strategies

(This special issue belongs to the Section Molecular Biology)

Molecular Insight into Catalysis of Nanomaterials

edited by Dandan Liu

submission deadline 20 Apr 2026 | 1 articles | Viewed by 773 | Submission Open

Keywords: nanomaterial catalyst; thermal catalysis; photocatalysis; electrocatalysis; DFT calculation

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Advances in Assisted Reproductive Technologies

edited by

Sung Tae Kim

submission deadline 20 Apr 2026 | 1 articles | Viewed by 725 | Submission Open

Keywords: preimplantation genetic testing; embryo selection; in vitro fertilization; infertility; implantation failure; miscarriage; mosaicism; segmental aneuploidy; non-invasive technology; morpho kinetics; in vitro gametogenesis; in vitro oocyte maturation; reproductive tissue cryopreservation; artificial intelligence (AI)

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms in Cardiovascular Disease Progression

edited by Ying-Hsi Lin

submission deadline 20 Apr 2026 | 1 articles | Viewed by 721 | Submission Open

Keywords: cardiovascular disease progression; molecular mechanisms; inflammation; signal transduction; transcriptional and epigenetic regulation; mitochondrial dysfunction; sarcomeric remodeling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Roles of Non-Coding RNAs in Cancer

edited by Amit K. Mitra

submission deadline 20 Apr 2026 | 1 articles | Viewed by 651 | Submission Open

Keywords: lncRNA; miRNA; cancer; genomics; targeted therapy; biomarkers; drug resistance

(This special issue belongs to the Section Molecular Genetics and Genomics)

Emerging Plastic-Related Toxicity: From Environmental Exposure to Human Health

edited by

Antonietta Santoro

and

Marta Anna Szychlinska

submission deadline 20 Apr 2026 | 1 articles | Viewed by 619 | Submission Open

Keywords: (bio)plastic- and (bio)polymer-related toxicity; microplastic and nanoplastic accumulation/degradation in mammals; cell cultures; human health; in vivo models; epigenetics effects; endocrine disruptor properties of bioplastics; plastics and inflammation; plastics in neurodegeneration and neuroinflammation; reproduction; cell metabolism; immunomodulation

(This special issue belongs to the Section Molecular Toxicology)

Functional Food: Bridging the Gap Between Nutrition and Health

edited by Agata Kryczyk-Poprawa and

Wlodzimierz Opoka

submission deadline 20 Apr 2026 | 1 articles | Viewed by 590 | Submission Open

Keywords: functional foods; bioactive compounds; molecular targets; personalized nutrition strategies; chronic disease prevention; healthy aging; nutrient interactions

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Evolutionary Genomics in Plants: From Single Gene to Genome

edited by

Bei Gao

submission deadline 20 Apr 2026 | 1 articles | Viewed by 589 | Submission Open

Keywords: evolutionary genomics; plant adaptation; genome evolution; crop improvement; bioinformatics; polyploidy

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Hypertension

edited by Pedro A. José

submission deadline 20 Apr 2026 | Viewed by 579 | Submission Open

Keywords: salt sensitivity; inverse salt sensitivity; epigenetics; genetics; organ-to-organ communication

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

MicroRNAs in Physiology and Pathophysiology

edited by Małgorzata Guz

submission deadline 20 Apr 2026 | 1 articles | Viewed by 557 | Submission Open

Keywords: miRNA; cell physiology; metabolism; cancer; biomarkers; disease; molecular mechanisms; diagnosis; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Major Histocompatibility Complex Antigens in Disease

edited by Jerzy K. Kulski and Charles E. Larsen

submission deadline 20 Apr 2026 | Viewed by 542 | Submission Open

Keywords: major histocompatibility complex; immune response; human leukocyte antigen (HLA); immune function; disease susceptibility; pathogen resistance; antigenic transposable elements; cancer

(This special issue belongs to the Section Molecular Immunology)

Membrane Channels in Intercellular Communication

edited by

Camillo Peracchia

and

Jean Jiang

submission deadline 20 Apr 2026 | 1 articles | Viewed by 541 | Submission Open

Keywords: gap junctions; connexins; innexins; channels; hemichannels; connexin mutations; channel gating; chemical gating; voltage gating; cell– cell coupling; cell-cell uncoupling; cell communication; intercellular communication; calcium; pH

(This special issue belongs to the Section Biochemistry)

Recent Advancements in Studying Biomacromolecule–Ligand Interactions

edited by

Guo-Ping Zhou

submission deadline 20 Apr 2026 | Viewed by 531 | Submission Open

Keywords: biomacromolecule– ligand interaction; X-ray crystallography; nuclear magnetic resonance (NMR) spectroscopy; surface plasmon resonance (SPR); isothermal titration calorimetry (ITC); fluorescence spectroscopy (FS); mass spectrometry (MS); drug discovery

(This special issue belongs to the Section Macromolecules)

Natural Compounds for Skeletal Muscle Health and Regeneration

edited by

Khurshid Ahmad

submission deadline 20 Apr 2026 | Viewed by 522 | Submission Open

Keywords: skeletal muscle; natural compounds; molecular mechanism; muscle regeneration; computational analysis; experimental analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular and Clinical Advances in Ophthalmic Inflammation, Infection, and Degeneration

edited by Hyun Jin Shin

submission deadline 20 Apr 2026 | Viewed by 516 | Submission Open

Keywords: ophthalmic inflammation; ocular infection; ocular degeneration; molecular mechanisms; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring the Impact of the Biological Clock on Health and Disease

edited by

Bojlul Bahar

submission deadline 20 Apr 2026 | Viewed by 500 | Submission Open

Keywords: circadian rhythm; inflammation; oxidative stress; energy balance; metabolic syndrome; ageing; cancer; diabetes; obesity; entrainment; synchrony; melatonin

(This special issue belongs to the Section Molecular Biology)

Mitochondrial Energy Metabolism in Cells and Tissues

edited by

Alexander Remels

submission deadline 20 Apr 2026 | Viewed by 454 | Submission Open

Keywords: mitochondria; mitophagy; mitochondrial biogenesis; mitochondrial dynamics; fusion; fission; energy metabolism

(This special issue belongs to the Section Molecular Biology)

Molecular Biology and Chemistry of Mycotoxins and Phytotoxins, 3rd Edition

edited by

Makoto Kimura

submission deadline 20 Apr 2026 | Viewed by 450 | Submission Open

Keywords: aflatoxins; trichothecenes; fumonisins; ochratoxins; host-specific toxins; Alternaria toxins; emerging mycotoxins; biosynthesis; gene cluster; transcriptional regulation; toxicity; modification; ecological role

(This special issue belongs to the Section Molecular Toxicology)

Nose-to-Brain Drug Delivery: Opportunities and Challenges

edited by

Daisuke Inoue

submission deadline 20 Apr 2026 | Viewed by 441 | Submission Open

Keywords: nose-to-brain drug delivery; brain drug delivery system; CNS diseases; intranasal administration; nasal formulation

(This special issue belongs to the Section Molecular Pharmacology)

Psychobiotics as Next-Generation Probiotics: A Holistic Approach to Mental Health and Gut–Brain Axis Modulation

edited by

Edyta Juszczuk-Kubiak

submission deadline 20 Apr 2026 | Viewed by 431 | Submission Open

Keywords: probiotics; gut microbiota; gut– brain axis; mental health

(This special issue belongs to the Section Molecular Biology)

Research Progress of Orthopedic Materials

edited by Robert Karpiński

submission deadline 20 Apr 2026 | Viewed by 415 | Submission Open

Keywords: biocompatibility; biomaterials; orthopedic implants; hydroxyapatite; biodegradable polymers; tissue engineering; bioactive surfaces; bone cements; bone regeneration; antibacterial coatings

(This special issue belongs to the Section Materials Science)

Immune Regulation During Pregnancy

edited by Sabrina Marie Scroggins

submission deadline 20 Apr 2026 | Viewed by 411 | Submission Open

Keywords: maternal– fetal immunology; multiomics in pregnancy; in utero inflammation; therapeutics; placental biology; neurodevelopment; gestational disorders; epigenetics; microbiome

(This special issue belongs to the Section Molecular Immunology)

Advanced Nanomaterials for Bone Regeneration and Osseointegration

edited by Cristian Covarrubias

submission deadline 20 Apr 2026 | Viewed by 396 | Submission Open

Keywords: nanomaterials; bone regeneration; osseointegration; bifunctional biomaterials; bioceramics; metal nanoparticles; metal-organic frameworks (MOFs); nanostructured surfaces; composite materials; tissue engineering

(This special issue belongs to the Section Molecular Nanoscience)

Nanotechnology in Drug Delivery: Applications and Perspectives

edited by Ádám Juhász

submission deadline 20 Apr 2026 | Viewed by 393 | Submission Open

Keywords: nanostructured materials; drug delivery; drug– carrier interactions; hydrogel; aerogels; associated colloids; surfactants; macromolecules; blood– brain barrier; controlled release

(This special issue belongs to the Section Molecular Nanoscience)

Preparations and Applications of Aerogels and/or Cryogels: From a Molecular Perspective

edited by

Angelika Kmita

and

Dorota Lachowicz

submission deadline 20 Apr 2026 | Viewed by 392 | Submission Open

Keywords: inorganic and/or organic aerogels; hybrid materials; eco-friendly materials; diagnosis

(This special issue belongs to the Section Materials Science)

New Advances in Genetic and Molecular Mechanisms Underlying Agronomic Traits in Crops

edited by Hongbin Zhang

submission deadline 20 Apr 2026 | Viewed by 378 | Submission Open

Keywords: agronomic traits; crops; vegetable crops; fruit trees; genetic; molecular; high-throughput sequencing; agronomic genes

(This special issue belongs to the Section Molecular Plant Sciences)

Attosecond Science: Toward Applications in Biology, Chemistry and Medicine

edited by

Predrag Ranitovic

submission deadline 20 Apr 2026 | Viewed by 374 | Submission Open

Keywords: ultrafast light– matter interaction; high-harmonic generation; strong-field ionization; free-electron laser (FEL) ultrafast sources

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Mechanism of Diabetes and Its Complications

edited by Michishige Terasaki

submission deadline 20 Apr 2026 | Viewed by 363 | Submission Open

Keywords: diabetes; hyperglycemia; oxidative stress; atherosclerosis; comorbidity; complication; metabolic metabolic dysfunction associated steatotic liver disease (MASLD); steatohepatitis (MASH); chronic kidney disease (CKD); heart failure; heart failure with preserved ejection fraction (HFpEF); coronary artery disease (CAD)

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Photodiagnosis and Photodynamic Therapy

edited by

Tomasz Kubrak

and

David Aebisher

submission deadline 20 Apr 2026 | Viewed by 351 | Submission Open

Keywords: photodiagnosis; photodynamic therapy; photosensitizers; natural photosensitizers; biomedical imaging; nanomedicine; targeted therapies; light as a therapeutic tool

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms and Non-Conventional and Complementary Treatments for Inflammatory Bowel Disease

edited by Roberta Ottria and

Giovanni Maconi

submission deadline 20 Apr 2026 | Viewed by 347 | Submission Open

Keywords: inflammatory bowel disease; leaky gut; molecular mechanisms; inflammatory pathways; small molecules in inflammatory bowel disease; non-conventional treatment; complementary medicine; inflammatory cytokines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurotoxicity: Cellular Death Mechanisms in the Pathogenesis of Neurodegenerative Diseases

edited by