Advanced Nanomaterials for Bone Regeneration and Osseointegration
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".
Deadline for manuscript submissions: 30 October 2025 | Viewed by 125
Special Issue Editor
Special Issue Information
Dear Colleagues,
Bone regeneration and osseointegration represent major challenges in clinical practice, particularly in the treatment of large bone defects, compromised healing and the long-term integration of implants in orthopedic, maxillofacial, and dental applications. In this context, nanomaterials have emerged as a promising class of biomaterials capable of enhancing bone repair and improving the biological fixation of implants. Their unique physicochemical properties allow for controlled release of therapeutic agents, tailored surface bioactivity, and modulation of the cellular microenvironment. Nanostructured materials such as bioceramics, metal nanoparticles, metal–organic frameworks (MOFs), nanostructured particles, functionalized surfaces or coatings, and a wide range of composite and hybrid systems offer exciting opportunities for innovation. This Special Issue also welcomes studies on bifunctional nanomaterials—those designed to promote bone tissue regeneration or implant osseointegration while providing additional therapeutic benefits such as antimicrobial activity, inhibition of osteosarcoma recurrence, or modulation of inflammatory responses. We invite original research articles and reviews addressing the synthesis, functionalization, biological evaluation, and clinical potential of such advanced nanomaterials. Studies combining molecular biology, biomaterials science, and translational research are particularly encouraged.
Topics for this Special Issue include, but are not limited to, the following:
- Design and synthesis of nanomaterials for bone tissue regeneration;
- Surface modifications and coatings with nanomaterials to enhance bone–implant osseointegration;
- Bifunctional nanomaterials for bone applications, offering additional antimicrobial, anticancer (e.g., osteosarcoma), or immunomodulatory effects;
- Nanostructured bioceramics and metallic nanomaterials for bone repair in orthopedic and dental contexts;
- Metal–organic frameworks (MOFs) and other nanostructured systems for bone tissue engineering and regeneration;
- Nanostructured scaffolds and composite nanomaterials tailored for bone tissue reconstruction;
- In vitro and in vivo evaluation of nanomaterials in bone regeneration and osseointegration models;
- Molecular and cellular mechanisms involved in bone formation promoted by nanomaterial-based approaches;
- Translational and clinical strategies using nanomaterials for bone regeneration and implant osseointegration.
Dr. Cristian Covarrubias
Guest Editor
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Keywords
- nanomaterials
- bone regeneration
- osseointegration
- bifunctional biomaterials
- bioceramics
- metal nanoparticles
- metal-organic frameworks (MOFs)
- nanostructured surfaces
- composite materials
- tissue engineering
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