Immune Cell Therapy and Genome Engineering
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 72
Special Issue Editor
Interests: mitochondria; cancer; chronic diseases; infectious disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Immune cell therapies, such as CAR-T cells, TCR-T cells, and NK cell therapies, are transforming the landscape of cancer treatment and chronic immune disorders. These therapies harness and reprogram the patient’s immune cells to recognize, target, and eliminate disease-causing cells. Beyond oncology, immune cell therapies are showing promise in infectious diseases and autoimmune conditions, offering a highly personalized therapeutic approach.
Regenerative therapy seeks to repair or replace damaged cells, tissues, and organs using stem cells, biomaterials, and bioengineered constructs. Innovations in mesenchymal stem cell (MSC) therapy, platelet-rich plasma (PRP), exosome therapies, and tissue engineering are redefining possibilities for healing and recovery in degenerative, inflammatory, and trauma-related conditions. These strategies hold significant promise for neurodegeneration, cardiovascular repair, musculoskeletal restoration, and beyond.
Advancements in gene editing technologies, such as CRISPR-Cas9, base editors, and prime editors, allow precise alterations in the genome to correct genetic defects or modulate disease pathways. These tools are rapidly being integrated into therapeutic pipelines for monogenic diseases, oncology, infectious diseases, and even for enhancing immune cell therapies. The combination of gene editing with cell-based platforms offers a powerful modality for curative interventions.
Understanding gene regulation at the epigenetic level—through DNA methylation, histone modifications, non-coding RNAs, and chromatin architecture—adds a crucial layer to precision medicine. Epigenetic modulation can influence disease susceptibility, therapeutic response, and aging processes. The emergence of epigenome-editing tools allows targeted modulation of gene expression without altering the underlying DNA sequence, offering reversible and programmable control of cellular behavior.
This Special Issue aims to highlight the integration of cutting-edge innovations in immune modulation, regeneration, genome engineering, and epigenetic reprogramming—ushering in a new era of systems-level, personalized, and regenerative medicine. These interwoven disciplines not only enhance therapeutic precision but also redefine the boundaries of what is biologically and clinically possible.
Prof. Dr. Kieu C. D. Nguyễn
Guest Editor
Manuscript Submission Information
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Keywords
- immune cell therapies
- regenerative therapy
- gene editing technologies
- epigenetic modulation
- precision medicine
- personalized therapy
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