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Molecular Biology and Chemistry of Mycotoxins and Phytotoxins, 3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: closed (20 April 2026) | Viewed by 1253

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Guest Editor
Department of Biological Mechanisms and Function, Graduate School of Bioagricultural Sciences, Nagoya University, Furo‐cho, Chikusa‐ku, Nagoya 464‐8601, Aichi, Japan
Interests: fungal molecular biology; mycotoxin biosynthesis and regulation; secondary metabolism; plant-pathogen interaction; gene expression
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Special Issue Information

Dear Colleagues,

This Special Issue continues on from our previous Special Issues, “Molecular Biology and Chemistry of Mycotoxins and Phytotoxins” and “Molecular Biology and Chemistry of Mycotoxins and Phytotoxins 2.0”.

Many filamentous fungi can grow on pre- or post-harvest crops under favorable growth conditions, either parasitically or saprophytically. In this process, they often produce secondary metabolites with ecological significance. Such small molecules were traditionally termed as mycotoxins (fungal toxins active toward animals) and phytotoxins (fungal toxins active toward plants); however, it is now evident that this categorization does not appropriately represent the nature of the toxic chemicals. For example, fumonisins and AAL-toxins (host-specific toxins) are mycotoxins and phytotoxins, respectively, and yet they share the same polyketide backbone and biological activity. Trichothecene mycotoxins contribute to plant disease development and play minor roles as phytotoxins. The biosynthesis genes of toxins involved in biological interactions tend to evolve extensively and generate structural diversity of the toxin side-chains.

This Special Issue, entitled “Molecular Biology and Chemistry of Mycotoxins and Phytotoxins”, deals with the various aspects of fungal toxins potentially involved in the survival of the producers in their ecological niche. The scope of this Issue includes, but is not limited to, the following:

  • Biosynthesis of fungal secondary metabolites with ecological significance;
  • Structural diversity of fungal toxins, such as trichothecenes and fumonisins;
  • Regulation of fungal toxin gene expression;
  • Plant, microbial, and animal responses to toxigenic fungi and toxins

We wholeheartedly welcome both original research articles and reviews on fungal toxins.

Prof. Dr. Makoto Kimura
Guest Editor

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Keywords

  • aflatoxins
  • trichothecenes
  • fumonisins
  • ochratoxins
  • host-specific toxins
  • Alternaria toxins
  • emerging mycotoxins
  • biosynthesis
  • gene cluster
  • transcriptional regulation
  • toxicity
  • modification
  • ecological role

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Published Papers (1 paper)

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Research

15 pages, 3098 KB  
Communication
Culture Condition-Dependent Acylation Patterns of Trichothecenes in a T-2 Toxin-Producing Strain of Fusarium sporotrichioides NBRC 9955
by Kazuyuki Maeda, Yuya Tanaka, Yuichi Nakajima, Kosuke Matsui, Yoshiaki Koizumi, Shuichi Ohsato, Naoko Takahashi-Ando and Makoto Kimura
Int. J. Mol. Sci. 2026, 27(2), 1030; https://doi.org/10.3390/ijms27021030 - 20 Jan 2026
Viewed by 617
Abstract
Fusarium sporotrichioides strain M-1-1, originally deposited as Fusarium solani IFO 9955 in 1974 and later moved to NBRC, is known for producing T-2 toxin. In addition to NRRL 3299, which was used in the United States to study T-2 toxin biosynthesis, NBRC 9955 [...] Read more.
Fusarium sporotrichioides strain M-1-1, originally deposited as Fusarium solani IFO 9955 in 1974 and later moved to NBRC, is known for producing T-2 toxin. In addition to NRRL 3299, which was used in the United States to study T-2 toxin biosynthesis, NBRC 9955 has been extensively used for trichothecene research in Japan. To facilitate and accurately document studies on trichothecene biosynthesis using NBRC 9955, its phylogenetic classification and trichothecene metabolite profiles were determined. As anticipated, NBRC 9955 was classified as F. sporotrichioides, which exhibited a more distant phylogenetic relationship to other strains within the same species. Time-course TLC analyses demonstrated the accumulation of various deacetylated trichothecenes in yeast extract-rich liquid media during the late growth stages. Conversely, an increase in 3-O-acetylation of T-2 toxin was observed at late stages when cultivated in micronutrient-poor synthetic liquid medium. Northern blot analysis revealed that Tri8 expression halted in cultures with the synthetic medium, which accounts for the growth stage-dependent 3-O-acetylation observed. On a brown rice flour solid medium, the fungal strain produced mixtures of T-2 toxin, neosolaniol, HT-2 toxin, and their 3-O-acetyl derivatives. These results highlight the risk of underestimating the levels of toxic trichothecene metabolites when using the standard contamination monitoring protocols. Full article
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