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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Functional Genomics in Translational Medicine

edited by

Cornelia Braicu

, Oana Zanoaga and

Ștefan Strilciuc

submission deadline 20 Aug 2026 | 2 articles | Viewed by 6864 | Submission Open

Keywords: functional genomics; omics approaches; drug response/resistance; therapeutic targets; genomics and transcriptomic alteration; bioinformatic analysis; data integration; human disease; personalized medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Neurodegenerative Diseases: Genetic Bases and Pathogenetic Mechanisms

edited by Emanuele Panza

submission deadline 20 Aug 2026 | 3 articles | Viewed by 6607 | Submission Open

Keywords: neurodegenerative diseases; molecular and cellular pathways; pathogenetic mechanisms

(This special issue belongs to the Section Molecular Neurobiology)

Fish Nutrition, Biochemical Pathways, and Physiological Adaptations

edited by Paula Simó-Mirabet and Fernando Naya-Català

submission deadline 20 Aug 2026 | 2 articles | Viewed by 6511 | Submission Open

Keywords: fish; nutrition; metabolism; physiology; growth performance; fish stress; transcriptomics; metataxonomics; metagenomics; epigenomics; aquaculture

(This special issue belongs to the Section Molecular Biology)

Progress in Adipokines Research in Cardiovascular Health and Diseases

edited by

Morris Karmazyn

submission deadline 20 Aug 2026 | 4 articles | Viewed by 5888 | Submission Open

Keywords: adipokine receptors and cell signalling; adipokines and heart failure and hypertrophy; adipokines and myocardial ischemia; adipokines and hypertension; adipokines and thrombosis/atherosclerosis; adipokines and vascular/endothelial function, structure, and integrity; adipokines and cardiovascular inflammation; adipokines, adiposity, and cardiovascular disease in obesity

(This special issue belongs to the Section Molecular Biology)

Hearing Loss: Molecular Biological Insights, 2nd Edition

edited by María Beatriz Durán-Alonso

submission deadline 20 Aug 2026 | 4 articles | Viewed by 5445 | Submission Open

Keywords: genetics; microRNA; epigenetics; CRISPR; multi-omics; presbycusis; ototoxicity; development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Intestinal Diseases and Gut Microbiota

edited by

Anna Duda-Madej

submission deadline 20 Aug 2026 | 2 articles | Viewed by 5319 | Submission Open

Keywords: gut microbiota; dysbiosis; natural compounds; colorectal cancer; neurological diseases; autoimmune diseases; probiotics; gut-brain axis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Products in Cancer Prevention and Treatment—Second Edition

edited by

Simona Serini

and

Gabriella Calviello

submission deadline 20 Aug 2026 | 3 articles | Viewed by 5289 | Submission Open

Keywords: natural products; cancer; therapeutic strategies; novel molecular pathways

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Microbial Fermentation: Advances in Synthetic Biology, Metabolic Engineering, and Biomanufacturing

edited by

Yaokang Wu

submission deadline 20 Aug 2026 | 4 articles | Viewed by 4884 | Submission Open

Keywords: microbial fermentation; synthetic biology; metabolic engineering; biomanufacturing; industrial biotechnology

(This special issue belongs to the Section Molecular Microbiology)

Gene Regulation and Neurotoxicity in Alcohol Related Pathologies

edited by

Stefano Casalotti

submission deadline 20 Aug 2026 | 1 articles | Viewed by 4440 | Submission Open

Keywords: alcohol; ethanol; gene expression; neurotoxicity; epigenetics; polymorphisms; neu-rons; glial cell; plasticity

(This special issue belongs to the Section Molecular Neurobiology)

From Electronic Structure to Application: Computational Insights into Bioactive and Functional Molecules

edited by

Karolina Kula

submission deadline 20 Aug 2026 | 2 articles | Viewed by 4428 | Submission Open

Keywords: molecular design; molecular modeling; substituent effect; reactivity descriptors; biological potential; in silico study; physicochemical properties; ADME; PASS; QSAR

(This special issue belongs to the Section Molecular Informatics)

Molecular Mechanisms and Therapeutic Strategies for Pregnancy Complications

edited by

Joško Osredkar

submission deadline 20 Aug 2026 | 4 articles | Viewed by 4355 | Submission Open

Keywords: pregnancy complications; placenta diseases; molecular mechanisms; therapeutics; biomarkers; preeclampsia; gestational diabetes; intrauterine growth restriction; maternal-fetal exchange; inflammation mediators

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research on Immune Cells and Cytokines (3rd Edition)

edited by

Athanasia Mouzaki

submission deadline 20 Aug 2026 | 5 articles | Viewed by 4118 | Submission Open

Keywords: immune cells; cytokines; immunomodulatory treatments; immune diseases; immune system

(This special issue belongs to the Section Molecular Immunology)

Focus on Plant Biotechnology and Molecular Breeding

edited by

Magdalena Wróbel-Kwiatkowska

submission deadline 20 Aug 2026 | 4 articles | Viewed by 4111 | Submission Open

Keywords: genetic engineering; plant transformation; applied biotechnology; functional genomics; crop plants; crop improvement; plant tissue cultures; secondary metabolites

(This special issue belongs to the Section Molecular Plant Sciences)

Cell Proliferation and Differentiation in Cancer

edited by

Sérgio Paulo Bydlowski

submission deadline 20 Aug 2026 | 2 articles | Viewed by 4079 | Submission Open

Keywords: cell signaling; cell transduction; transcriptional and post-transcriptional pathways; growth factors; second messengers; cell proliferation; cell differentiation; cell metabolism; cell death; cell invasion

(This special issue belongs to the Section Molecular Oncology)

Advances in Colitis Research: Exploring Molecular Mechanisms and Immune Regulation

edited by

Jochen Mattner

submission deadline 20 Aug 2026 | 3 articles | Viewed by 4076 | Submission Open

Keywords: colitis; inflammation; infection; autoimmunity; mucosal tolerance; colonization resistance; intestinal microbiota; host-microbe interactions

(This special issue belongs to the Section Molecular Immunology)

The Impact of Cancer–Immune Cell Crosstalk on Diagnosis, Prognosis and Treatment

edited by Fabricio Figueiro

submission deadline 20 Aug 2026 | 2 articles | Viewed by 3999 | Submission Open

Keywords: protumoral immunity; anticancer immunity; crosstalk; tumor microenvironment; purinergic signaling; immune checkpoints; immunometabolism; extracellular vesicles; RNA communication

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antibiotics Science: Molecular Insights, Detection Strategies, Resistance Challenges and Interdisciplinary Applications

edited by

Lidia Magerusan

submission deadline 20 Aug 2026 | 3 articles | Viewed by 3998 | Submission Open

Keywords: antibiotics; antibiotic molecular design and synthesis; antibiotic action mechanism; antibiotics resistance; environmental contamination; therapeutic monitoring; antibiotic sensing and detection; food and environmental safety

(This special issue belongs to the Section Molecular Microbiology)

Advances in Mass Spectrometry-Based Proteomics: From Biomarker Discovery to Translational Applications

edited by

Yanlong Ji

submission deadline 20 Aug 2026 | 1 articles | Viewed by 3925 | Submission Open

Keywords: mass spectrometry; LC-MS method development; phosphoproteomics; glycoproteomics; biomarker discovery; multi-omics data integration

(This special issue belongs to the Section Biochemistry)

Plant Responses to Heavy Metals: From Deficiency to Excess, 2nd Edition

edited by

Anna D. Kozhevnikova

and

Ilya Vladimirovich Seregin

submission deadline 20 Aug 2026 | 3 articles | Viewed by 3900 | Submission Open

Keywords: heavy metals; deficiency; metal toxicity; metal (hyper-)accumulation; mechanisms of metal tolerance; metal transport; metal uptake; metal sequestration; metal homeostasis

(This special issue belongs to the Section Molecular Plant Sciences)

Environmental Pollutants Exposure and Toxicity

edited by

Tzveta Georgieva

submission deadline 20 Aug 2026 | 4 articles | Viewed by 3884 | Submission Open

Keywords: environmental pollutants exposure assessment; molecular methods; biomarkers; human safety; environmental safety

(This special issue belongs to the Section Molecular Toxicology)

Advances in Conventional Tree Breeding: Integrating Phenotypic Selection, Genetic Gain, and Sustainable Forest Management

edited by

Jingli Yang

submission deadline 20 Aug 2026 | 1 articles | Viewed by 3780 | Submission Open

Keywords: forest trees; genetic breeding; conventional tree breeding; forest management; forest tree varieties; modern molecular technology; genetic engineering

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances in Molecular and Cellular Approaches to Tuberculosis Pathogenesis, Treatment and Prevention

edited by

Selvakumar Subbian

submission deadline 20 Aug 2026 | 2 articles | Viewed by 3752 | Submission Open

Keywords: tuberculosis (TB); animal models of mycobacterium infections; molecular pathogenesis; host-directed therapy (HDT); nanoparticle drug delivery; vaccine development; cellular immunology; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in the Synthesis and Study of Novel Bioactive Molecules

edited by

Adriana Georgieva Bakalova

and

Emiliya Demireva Cherneva

submission deadline 20 Aug 2026 | 4 articles | Viewed by 3742 | Submission Open

Keywords: organic compounds; metal complexes; bioactive molecules

(This special issue belongs to the Section Biochemistry)

Recent Advances in Molecular Imaging and Therapy

edited by

Xuyi Yue

submission deadline 20 Aug 2026 | 2 articles | Viewed by 3698 | Submission Open

Keywords: molecular imaging; therapy; clinical translation; precision medicine; radiotheranostics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Regenerative and Anti-Aging Medicine

edited by

Takayuki Yoshimoto

submission deadline 20 Aug 2026 | 2 articles | Viewed by 3681 | Submission Open

Keywords: induced pluripotent stem cells (iPSCs); mesenchymal stem cells (MSCs); platelet-rich plasma (PRP); placenta; organoid; secretome; exosome; senolytics; nicotinamide mononucleotide (NMN); nicotinamide adenine dinucleotide+ (NAD+)

(This special issue belongs to the Section Molecular Biology)

Ferroptosis and Cuproptosis: Mechanism and Crosstalk in Cancer, Neurodegeneration, and Metabolic Syndrome

edited by

Rosanna Squitti

submission deadline 20 Aug 2026 | 3 articles | Viewed by 3674 | Submission Open

Keywords: ferroptosis; cuproptosis; Alzheimer's disease; colorectal cancer; neurodegeneration; metabolic syndrome; regulated cell death; iron metabolism; copper metabolism; psychiatric disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Abiotic Stress Signaling in Plants: Focus on Atmospheric Stressors, 2nd Edition

edited by

Mateusz Labudda

submission deadline 20 Aug 2026 | 2 articles | Viewed by 3631 | Submission Open

Keywords: abiotic stress; interactomics; gene expression regulation; kinases; oxidative stress; phytohormones; signaling, sugar sensing and signaling; transcription factors

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Research in Probiotic Yeasts: Molecular Aspects

edited by

Maurizio Ciani

and

Francesca Comitini

submission deadline 20 Aug 2026 | 2 articles | Viewed by 3438 | Submission Open

Keywords: probiotic yeasts; molecular mechanisms; mycocins active; compounds; functional compounds

(This special issue belongs to the Section Molecular Microbiology)

Molecular Genetics and Genomics of Aquatic Crustaceans

edited by

Xianhong Meng

, Falin Zhou and Lingbo Ma

submission deadline 20 Aug 2026 | 3 articles | Viewed by 3385 | Submission Open

Keywords: genome sequencing; epigenomics; CRISPR/Cas9 gene editing; transcriptomics; gene expression profiling; genome-wide association studies (GWASs); quantitative trait loci (QTL) mapping; genomic selection; marker-assisted selection (MAS); molecular markers

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Plant Nematology Research

edited by

Sergei A. Subbotin

submission deadline 20 Aug 2026 | 1 articles | Viewed by 3350 | Submission Open

Keywords: DNA barcoding; Molecular evolution; Genomes; Molecular systematics; Phylogenetics; Plant–nematode interactions; Transcriptomics

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Ion Channels in Health and Disease

edited by

Joohyun Nam

submission deadline 20 Aug 2026 | 2 articles | Viewed by 3347 | Submission Open

Keywords: ion channel; molecular mechanisms; channelopathies; drug discovery; electrophysiology

(This special issue belongs to the Section Molecular Biology)

Novel Agents and Molecular Research in Multiple Myeloma

edited by

Claudio Cerchione

submission deadline 20 Aug 2026 | 1 articles | Viewed by 3333 | Submission Open

Keywords: multiple myeloma; novel agents; target therapy; immunotherapy; bispecific antibodies; CAR-T

(This special issue belongs to the Section Molecular Oncology)

The Biogenesis, Structure, Function and Division of Plastids

edited by

Xiaomin Liu

and Li'na Yin

submission deadline 20 Aug 2026 | 1 articles | Viewed by 3248 | Submission Open

Keywords: plastid; chloroplast; chlorophyll; endosymbiotic cyanobacteria; photosynthesis; genetic engineering

(This special issue belongs to the Section Biochemistry)

Advanced Research on Plant-Derived Products in the Service of Immune Regulation

edited by

Lyuba Dineva Miteva

submission deadline 20 Aug 2026 | 2 articles | Viewed by 3236 | Submission Open

Keywords: plant bioactive compound; inflammation; immunity; cytokine; chronic disease

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Next Generation Sequencing in Human Diseases

edited by

Manuel Muro

submission deadline 20 Aug 2026 | 2 articles | Viewed by 3202 | Submission Open

Keywords: NGS; single-cell analysis; metagenomics; forensic DNA analysis; precision medicine; genetic diagnostics; transplant monitoring; cell-free DNA; new allele and variant discovery

(This special issue belongs to the Section Molecular Informatics)

Molecular Insight into Natural Nutraceuticals for Cancer Chemoprevention

edited by

Jia-Feng Chang

and

Chih-Hsin Tang

submission deadline 20 Aug 2026 | 2 articles | Viewed by 3168 | Submission Open

Keywords: natural nutraceuticals; cancer; cancer chemoprevention; natural compounds

(This special issue belongs to the Section Molecular Oncology)

Molecular Studies on Wnt Signaling

edited by Katalin Mészáros

submission deadline 20 Aug 2026 | 2 articles | Viewed by 3101 | Submission Open

Keywords: Wnt signaling pathway; inhibitor; cancer; treatment; drugs

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Embryo Developmental Potential: 2nd Edition

edited by

Jan Tesarik

submission deadline 20 Aug 2026 | 1 articles | Viewed by 3034 | Submission Open

Keywords: embryo developmental potential; oocyte quality; sperm quality; non-invasive techniques; molecular biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Medicinal Plants and Natural Products: Second Edition

edited by

Teresa Leszczyńska

Barbara Borczak

and

Joanna Kapusta-Duch

submission deadline 20 Aug 2026 | 2 articles | Viewed by 3001 | Submission Open

Keywords: medicinal plants; natural products; phytochemistry; bioactive substances; medicinal properties

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Research on Gut Microbiota in Health and Disease

edited by Li Cui

submission deadline 20 Aug 2026 | 3 articles | Viewed by 2998 | Submission Open

Keywords: microbiota-host crosstalk; HMA models; microbial metabolites; gut–brain axis; translational microbiome

(This special issue belongs to the Section Molecular Microbiology)

Molecular Insights in Food Science: From Nutritional Value to Safety Evaluation

edited by

Mariachiara Bianco

submission deadline 20 Aug 2026 | 3 articles | Viewed by 2972 | Submission Open

Keywords: nutraceutical; food safety; analytical methods; novel foods; food analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Targeting Epilepsy: Molecular Mechanisms, Neuroinflammation and Emerging Therapies

edited by

Karoly Orban-Kis

submission deadline 20 Aug 2026 | 2 articles | Viewed by 2939 | Submission Open

Keywords: epilepsy; molecular targets; antiepileptic drug discovery; neuroinflammation; epileptogenesis; ion channels; pharmacoresistance; translational neuroscience

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Peptides: Discovery, Synthesis, and Therapeutic Applications

edited by

Chuan-Mu Chen

submission deadline 20 Aug 2026 | 2 articles | Viewed by 2799 | Submission Open

Keywords: bioactive peptides; functional food-derived peptides; antimicrobial and antiviral peptides; peptide drug design and delivery; anticancer peptides; peptide-based therapeutics; regenerative medicine; immunomodulatory peptides; structure–function relationships; translational peptide research

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Oral Potentially Malignant Disorders and Oral Cancers: From Molecular Pathology to Therapeutic Approaches

edited by

Ana Caruntu

and Nicholas Kalavrezos

submission deadline 20 Aug 2026 | 2 articles | Viewed by 2790 | Submission Open

Keywords: oral cancer; oral potentially malignant disorders; molecular mechanisms in oral cancer; detection of oral cancer; pathogenic mechanisms of oral cancer; immune system; translational oral cancer; microbiota oral cancer; therapy for oral cancer

(This special issue belongs to the Section Molecular Oncology)

Artificial Intelligence Advancing Computer-Aided Drug Discovery

edited by

Raju Dash

submission deadline 20 Aug 2026 | 4 articles | Viewed by 2756 | Submission Open

Keywords: machine learning; deep learning; computer-aided drug design; target identification; AI-assisted molecular diagnosis; AI-driven pharmacokinetic profiling; virtual screening; network pharmacology; drug repurposing; molecular dynamics simulation; computational chemistry; AI in nanotechnology

(This special issue belongs to the Section Molecular Informatics)

The Role of Extracellular Histones in Patho(physio)logical Hemostasis

edited by Fabrizio Semeraro and

Mauro Coluccia

submission deadline 20 Aug 2026 | 2 articles | Viewed by 2752 | Submission Open

Keywords: extracellular histones; hemostasis; platelets; coagulation; fibrinolysis; thrombosis; inflammation; extracellular traps

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Acute Myeloid Leukemia: From Molecular Insights to Therapeutic Innovations

edited by

Lukasz Szymanski

submission deadline 20 Aug 2026 | 3 articles | Viewed by 2720 | Submission Open

Keywords: acute myeloid leukemia; AML; epigenetic Mechanisms; genetics; epigenetic regulation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advanced Oxidation Processes for the Decontamination of Emerging Contaminants and Disinfection of Pathogenic Microorganisms

edited by

Chengdu Qi

submission deadline 20 Aug 2026 | 1 articles | Viewed by 2717 | Submission Open

Keywords: advanced oxidation processes; emerging contaminants; pathogenic microorganisms; disinfection; hydroxyl radical; sulfate radical; organic radical

(This special issue belongs to the Section Molecular Microbiology)

Upcycling Food Industry By-Products: Bioactive Ingredients for Nutrition and Health

edited by

Giusy Rita Caponio

and

Graziana Difonzo

submission deadline 20 Aug 2026 | 1 articles | Viewed by 2657 | Submission Open

Keywords: bioactive compounds; food by-products; functional foods; molecular mechanisms; polyphenols; oxidative stress; inflammation; nutrigenomics; microbiome; prebiotics; postbiotics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

RNA Biology: Unraveling the Complex Interplay Between Proteins and RNAs in Gene Expression and Regulation, 2nd Edition

edited by

Rosemary Kiernan

submission deadline 20 Aug 2026 | 2 articles | Viewed by 2645 | Submission Open

Keywords: RNA biology; protein–RNA interplay; gene expression; post-transcriptional modifications; non-coding RNAs

(This special issue belongs to the Section Molecular Genetics and Genomics)

Displaying special issue 51-100 on page 2 of 63.

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