Molecular Mechanisms and Therapeutic Strategies for Pregnancy Complications
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 18
Special Issue Editor
Interests: pregnancy complications; screening for Down syndrome; autism spectrum disorders; tumor markers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We announce a forthcoming Special Issue in the International Journal of Molecular Sciences (IJMS) entitled “Molecular Mechanisms and Therapeutic Strategies for Pregnancy Complications.” This Special Issue will gather high-quality original research articles, reviews, and perspectives that focus on molecular pathways, novel diagnostic biomarkers, and therapeutic strategies related to complications of pregnancy.
Pregnancy is a complex physiological process governed by finely tuned interplay between maternal and fetal systems. While most pregnancies proceed without significant issues, a considerable proportion is complicated by conditions that can jeopardize maternal and fetal health. These include pre-eclampsia, gestational diabetes mellitus, intrauterine growth restriction (IUGR), preterm birth, placental insufficiency, recurrent pregnancy loss, and infections such as chorioamnionitis. Despite advances in obstetric care, the underlying molecular and cellular mechanisms of many of these disorders remain incompletely understood, and effective targeted treatments are still lacking.
This Special Issue will provide a platform for disseminating innovative research that contributes to our understanding of the molecular and cellular basis of pregnancy-related disorders, as well as potential interventions. We welcome submissions that address, but are not limited to, the following themes:
- Molecular and cellular mechanisms underlying pregnancy complications;
- Epigenetic and genetic factors contributing to placental dysfunction;
- Oxidative stress, inflammation, and immune dysregulation in pregnancy pathologies;
- Biomarkers for early prediction, diagnosis, and monitoring of pregnancy complications;
- Novel drug targets and pharmacological interventions;
- Therapeutic strategies including nutraceuticals, gene therapy, and biologics;
- Role of extracellular vesicles, microRNAs, and long non-coding RNAs;
- Microbiome and its influence on pregnancy outcomes;
- Maternal-fetal interactions and signaling pathways in normal and pathological pregnancies;
- Systems biology and omics approaches (transcriptomics, metabolomics, proteomics)/
We also encourage submissions that present translational or clinical research findings, as well as in vitro, animal model, and computational studies that may lead to the development of innovative therapies or diagnostics.
The International Journal of Molecular Sciences (IJMS) is an international, peer-reviewed open-access journal published by MDPI, with an impact factor of 4.9. The journal provides rapid publication of high-quality scientific papers and has a broad readership in the fields of molecular biology, biochemistry, physiology, and medical sciences.
This Special Issue offers a unique opportunity to publish your work on a widely visible and indexed platform. All submitted manuscripts undergo rigorous peer review to ensure their high scientific standards and relevance to the scope of the Special Issue. Accepted papers will be published promptly and made freely available to the global scientific community.
Prof. Dr. Joško Osredkar
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pregnancy complications
- placenta diseases
- molecular mechanisms
- therapeutics
- biomarkers
- preeclampsia
- gestational diabetes
- intrauterine growth restriction
- maternal-fetal exchange
- inflammation mediators
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