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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advancements in Inflammatory and Oxidative Disease Research

edited by

Sandra Barbalho

submission deadline 31 Dec 2025 | Viewed by 227 | Submission Open

Keywords: diabetes; cancer; neurological diseases; inflammation; oxidative stress; endocrinology; gastroenterology; pulmonology; rheumatology; cardiology; neurology; nephrology; dermatology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Synthetic Lethality Strikes: Outsmarting Cancer with Precision Medicine

edited by

Stefania Butini

submission deadline 31 Dec 2025 | Viewed by 222 | Submission Open

Keywords: synthetic lethality; precision medicine; DDR modulators; non-DDR modulators; cancer; BRCA; PARP; RAD51; RAD52

(This special issue belongs to the Section Molecular Oncology)

Microtubule Cytoskeleton, Motor Proteins, and Other Cytoskeleton-Associated Proteins

edited by

Tibor Szénási

submission deadline 31 Dec 2025 | Viewed by 219 | Submission Open

Keywords: microtubule cytoskeleton; motor proteins (kinesins and dyneins); cytoskeleton-associated proteins; cytoskeletal “ cross-talk” ; intracellular transport; cellular signaling and regulation; cellular processes (mitosis; migration; and polarity)

(This special issue belongs to the Section Biochemistry)

Plant Responses to Microorganisms and Insects

edited by

Sumit Jangra

submission deadline 31 Dec 2025 | Viewed by 204 | Submission Open

Keywords: biotic stresses; crop protection; signaling molecules; transcriptomics; proteomics; microRNAs; resistance mechanism; plant– microbe– vector interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular, Cellular Mechanism of Oxidative Stress in Physiological and Pathophysiological Conditions, 2nd Edition

edited by Dominika Marta Stygar

submission deadline 31 Dec 2025 | Viewed by 202 | Submission Open

Keywords: oxidative stress; inflammation; obesity; civilization; diseases; molecular mechanism; cellular mechanism; biomarkers; bacterial and viral diseases; environmental stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Decoding Cardiovascular Disease: From Molecular Mechanisms to Clinically Translational Innovations

edited by Lisa Kitasato

submission deadline 31 Dec 2025 | Viewed by 202 | Submission Open

Keywords: cardiovascular disease; molecular mechanisms; translational research; biomarkers; cardiac remodeling; oxidative stress; inflammation; precision medicine; systems biology; regenerative cardiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Computational Approaches in Drug Discovery and Design: From Molecular Modeling to Translational Applications

edited by

Przemysław Czeleń

submission deadline 31 Dec 2025 | Viewed by 199 | Submission Open

Keywords: computational drug discovery; molecular modeling; AI-driven drug design; molecular dynamics simulations; quantum chemistry; structure-based drug design; machine learning in pharmacology; virtual screening and docking; ADMET prediction; personalized medicine modeling

(This special issue belongs to the Section Molecular Informatics)

New Insights into Antimicrobial Peptides with Anticancer Activity

edited by

Esther Imperlini

submission deadline 31 Dec 2025 | Viewed by 196 | Submission Open

Keywords: antimicrobial peptides; cytotoxicity; selective anticancer drugs; omics approaches; anticancer peptide action

(This special issue belongs to the Section Biochemistry)

Toxicology Research: Understanding and Predicting Compound—Induced Toxicity

edited by

Georgios Pampalakis

and

Eleni Zingkou

submission deadline 31 Dec 2025 | Viewed by 194 | Submission Open

Keywords: molecular toxicology; emerging toxicology; drug-induced toxicity; organ toxicology; animal models; in silico toxicology; in vitro models; pesticides; industrial chemicals

(This special issue belongs to the Section Molecular Toxicology)

The Role of Iron in Human Physiology: Molecular Mechanisms and Therapeutic Applications

edited by

Alireza Morovat

submission deadline 31 Dec 2025 | Viewed by 193 | Submission Open

Keywords: iron; hepcidin; ferroportin; ferritin; transferrin; metabolic regulation; cell signaling; cellular processes; mitochondrial function; stress response; inflammation; ferroptosis; gene regulation; disorders

(This special issue belongs to the Section Molecular Biology)

Consensus-Based Approaches to Rational Drug Design and Predictive Toxicology

edited by

Fernando Daniel Prieto-Martínez

submission deadline 31 Dec 2025 | Viewed by 191 | Submission Open

Keywords: drug design; bioactive compounds; pharmacophore; molecular dynamics; protein– ligand interactions; activity cliffs; machine learning

(This special issue belongs to the Section Molecular Toxicology)

Protein-Targeted Therapeutics: Functional Modulation in Disease Pathways

edited by

Sung-Kun (Sean) Kim

submission deadline 31 Dec 2025 | Viewed by 181 | Submission Open

Keywords: protein-targeted therapeutics; proteins inhibitors; ligand binding; conformational changes

(This special issue belongs to the Section Biochemistry)

Molecular and Electrochemical Mechanisms of Metal Corrosion

edited by

Mehrdad Faraji

submission deadline 31 Dec 2025 | 1 articles | Viewed by 179 | Submission Open

Keywords: metal corrosion; molecular mechanisms; electrochemistry; surface chemistry; corrosion inhibitors; passivation

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Advanced in In Silico Methods for Rational Drug Design and Predictive Toxicology

edited by

Gnanendra Shanmugam

submission deadline 31 Dec 2025 | Viewed by 178 | Submission Open

Keywords: rational drug design; predictive toxicology; molecular modeling; AI in drug discovery; QSAR; molecular docking; ADMET

(This special issue belongs to the Section Molecular Informatics)

Latest Review Papers in “Materials Science” Section

edited by

David P. Mills

submission deadline 31 Dec 2025 | Viewed by 178 | Submission Open

Keywords: biomaterials; coatings; materials phenomena; machine learning; nanocomposites; artificial intelligence

(This special issue belongs to the Section Materials Science)

Molecular and Cellular Research on Adipose Tissue Development and Functions, 2nd Edition

edited by

Younghoon Jang

submission deadline 31 Dec 2025 | Viewed by 177 | Submission Open

Keywords: adipose tissue; development; expansion; white adipose tissue; brown adipose tissue; beige adipose tissue; adipocytes; adipogenesis; lipogenesis; peroxisome proliferator-activated receptor gamma (PPAR-γ ); CCAAT enhancer binding proteins (CEBP-α ; CEBP-β ; and CEBP-δ ); carbohydrate response element binding protein (ChREBP)

(This special issue belongs to the Section Molecular Biology)

Fractalkine (CX3CL1) and Its Chemoattractant and Adhesion Molecule Properties in Health and Disease, 2nd Edition

edited by Dariusz Szukiewicz

submission deadline 31 Dec 2025 | Viewed by 176 | Submission Open

Keywords: fractalkine; transmembrane fractalkine; soluble fractalkine; fractalkine receptor; CX3CL1-CX3CR1 signaling; inflammation; chemokine; cell adhesion; chemotaxis; immune response; angiogenesis; implantation; atherosclerosis; carcinogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Early Diagnosis and Advanced Therapies of Genetic Disorders

edited by

Milen Velinov

submission deadline 31 Dec 2025 | Viewed by 174 | Submission Open

Keywords: genetic disorders; rare diseases; disease diagnostics; therapeutic targets; gene variants

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immunological Control of Vascular Plasticity: Insights into Arteriogenesis, Angiogenesis, and Atherosclerosis

edited by

Elisabeth Deindl

and

Hector A. Cabrera-Fuentes

submission deadline 31 Dec 2025 | Viewed by 165 | Submission Open

Keywords: vascular plasticity; arteriogenesis; angiogenesis; atherosclerosis; immune modulation; inflammation and vascular remodeling; translational vascular immunology; smooth muscle cell-/endothelial cell proliferation; sterile inflammation; collateral artery growth

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms Associated with Exercise for Health and Performance

edited by Ciro José Brito

submission deadline 31 Dec 2025 | Viewed by 164 | Submission Open

Keywords: exercise science; sports medicine; aging; genetic and exercise; endocrinology; immunology

(This special issue belongs to the Section Molecular Biology)

Synthesis and Structural Studies of Potential Anticancer Drugs

edited by Janusz Madaj

submission deadline 31 Dec 2025 | Viewed by 156 | Submission Open

Keywords: medicinal chemistry; drug discovery; design and synthesis of bioactive compounds; molecular modeling; X-ray crystallography; structure– activity relationships; structure-based drug design

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms of Nitric Oxide in Cardiovascular System

edited by

Elena Grossini

submission deadline 31 Dec 2025 | Viewed by 153 | Submission Open

Keywords: heart; nitric oxide; oxidative stress; pathways; protection; therapy; vascular

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Gut Microbiota—Its Role and Molecular Mechanisms in Nutritional Health

edited by

Xi Ma

and Peng Tan

submission deadline 31 Dec 2025 | 1 articles | Viewed by 153 | Submission Open

Keywords: gut microbiota; microbiome; mucosal immunity; probiotics; omics; dysbiosis; microbiota– host interactions; microbiota manipulation

(This special issue belongs to the Section Molecular Microbiology)

Systemic Lupus: Molecular Research, New Biomarkers and Novel Therapy

edited by Juan Pablo Mackern-Oberti

submission deadline 31 Dec 2025 | Viewed by 147 | Submission Open

Keywords: lupus; biomarkers; autoimmunity; inflammation; therapy; treatment; endocrine; prolactin; stress; T cell and B cell activation; T cell and B cell proliferation; antigenic immunosuppression

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Genetics and Genomics of Neurodevelopmental Disorders

edited by

Elisabetta Bolognesi

and

Franca Rosa Guerini

submission deadline 31 Dec 2025 | Viewed by 146 | Submission Open

Keywords: neurodevelopmental disorders; genetics; molecular biology; biomarkers; epigenetics; precision medicine; rare variants; common variants; artificial intelligence; machine learning

(This special issue belongs to the Section Molecular Genetics and Genomics)

Exploring Molecular Mechanisms of Prostate Cancer

edited by

Estefania Labanca

submission deadline 31 Dec 2025 | Viewed by 146 | Submission Open

Keywords: genetic alterations; signlaing pathways; cellular dysregulation; non-coding RNAs; epigenetics; tumor microenvironment; metabolic factors; therapuetic targeting; multi-modal approaches

(This special issue belongs to the Section Molecular Oncology)

Molecular and Cellular Basis of Oral Immunology

edited by

Kenichi Kumagai

submission deadline 31 Dec 2025 | Viewed by 145 | Submission Open

Keywords: oral immunology; oral mucosa; immune tolerance; oral microbiome; oral diseases; periodontium; innate immunity; adaptive immunity

(This special issue belongs to the Section Molecular Immunology)

Advances in Neuropharmacology in Neurodegenerative Disorders

edited by

Ichiro Kawahata

submission deadline 31 Dec 2025 | Viewed by 144 | Submission Open

Keywords: neuropharmacology; neurodegenerative disorders; cognitive dysfunction; motor dysfunction; drug discovery; neuroprotection; neurogenesis; brain plasticity; biomarkers; AI (artificial intelligence)

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Genome-Edited Animal Models

edited by Takayuki Sakurai and

Masahiro Sato

submission deadline 31 Dec 2025 | Viewed by 141 | Submission Open

Keywords: genome editing; prime editing; base editing; CRISPRa/CRISPRi; knock-in/out; conditional genome editing; multiplex genome editing; manipulation of early embryos and germ cells; in vivo gene delivery; genome-edited animals; disease animal model

(This special issue belongs to the Section Molecular Genetics and Genomics)

Micro/Nano-Structure Regulation of Two-Dimensional Materials

edited by

Ning Wang

submission deadline 31 Dec 2025 | Viewed by 140 | Submission Open

Keywords: 2D materials; micro/nano-engineering; structure– property relationships

(This special issue belongs to the Section Materials Science)

Molecular Adaptations of Arthropod Vectors to Oxidative Stress

edited by

Francisco José Alves Lemos

submission deadline 31 Dec 2025 | Viewed by 139 | Submission Open

Keywords: oxidative stress; arthropod vectors; molecular adaptation; redox biology; proteomics; stress response mechanisms

(This special issue belongs to the Section Molecular Biology)

Targeted Peptide Drugs for Metabolic Diseases

edited by

Lukasz Buldak

submission deadline 31 Dec 2025 | Viewed by 139 | Submission Open

Keywords: metabolic disorders; peptide drugs; MASLD; receptor targeting; lipid regulation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Research on Embryo Developmental Potential: 2nd Edition

edited by

Jan Tesarik

submission deadline 31 Dec 2025 | Viewed by 137 | Submission Open

Keywords: embryo developmental potential; oocyte quality; sperm quality; non-invasive techniques; molecular biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Discoveries in Virus–Cytoskeleton Regulation

edited by

Agustín Valenzuela-Fernández

submission deadline 31 Dec 2025 | Viewed by 136 | Submission Open

Keywords: viruses; cytoskeleton dynamics; actin; tubulin and intermediate filaments; infection; pathogenesis; therapies

(This special issue belongs to the Section Molecular Biology)

Natural Products in Cancer Prevention and Treatment—Second Edition

edited by

Simona Serini

and

Gabriella Calviello

submission deadline 31 Dec 2025 | Viewed by 136 | Submission Open

Keywords: natural products; cancer; therapeutic strategies; novel molecular pathways

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cellular, Immune and Molecular Pathways of Injury and Disease in Forensic and Legal Medicine

edited by

Sorin Hostiuc

submission deadline 31 Dec 2025 | Viewed by 133 | Submission Open

Keywords: molecular autopsy; cellular injury pathways; ischemia and hypoxia markers; molecular profiling of fatal injuries; forensic genetics and toxicogenomic

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Pathophysiology of Peripheral Neuropathies and Neuromuscular Disorders

edited by

Eleonora Galosi

submission deadline 31 Dec 2025 | Viewed by 133 | Submission Open

Keywords: peripheral neuropathies; neuromuscular disorders; small fiber neuropathy; neuropathic pain; nerve regeneration; molecular pathways; next-generation sequencing

(This special issue belongs to the Section Molecular Neurobiology)

Epigenetic Mechanisms in Pain

edited by Hsien-Yu Peng

submission deadline 31 Dec 2025 | Viewed by 133 | Submission Open

Keywords: chronic pain; epigenetics; molecular biomarkers; neural plasticity; ion channel function; synaptic transmission; therapeutic strategies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Gut Microbiota in Human Disease and Health: 2nd Edition

edited by

Silvia Turroni

and

Federica D'Amico

submission deadline 31 Dec 2025 | Viewed by 132 | Submission Open

Keywords: gut microbiota; human disease; human health; omics; microbiota– host interactions; microbiota manipulation

(This special issue belongs to the Section Molecular Microbiology)

Molecular Insights into Skin Health and Disease

edited by Federica Li Pomi

submission deadline 31 Dec 2025 | Viewed by 132 | Submission Open

Keywords: dermatology; molecular mechanisms; targeted therapy; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetic Susceptibility in Human Diseases

edited by Xiaowu Gai

submission deadline 31 Dec 2025 | Viewed by 131 | Submission Open

Keywords: bioinformatics; genomics; genetic susceptibility to disease; genetic variation; gene– environment interactions; biomarkers; epigenetic mechanisms; pharmacogenomics; population genetics; bioinformatics tools and databases; novel diagnostics; targeted therapies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Recombinant Proteins and Antibody Engineering for Diagnostic and Treatment of Emerging Infectious Diseases

edited by

Gustavo Helguera

submission deadline 31 Dec 2025 | Viewed by 124 | Submission Open

Keywords: recombinant proteins; antibody engineering; monoclonal antibodies; hemorrhagic fevers; tuberculosis; emerging infectious diseases; neglected viruses; diagnostics; therapeutic antibodies

(This special issue belongs to the Section Molecular Immunology)

Innovative Approaches to RNA-Based Therapeutics

edited by

Elzbieta Kierzek

submission deadline 31 Dec 2025 | Viewed by 124 | Submission Open

Keywords: RNA therapeutic; RNA drug; antisense therapy; siRNA; delivery; oligonucleotides; mRNA vaccine

(This special issue belongs to the Section Molecular Biology)

Advances in Stem Cell Biology and Translational Medicine

edited by Yangluowa Qu

submission deadline 31 Dec 2025 | Viewed by 124 | Submission Open

Keywords: stem cell regulation; differentiation; proliferation; self-renewal; stem cell-based therapy; tissue engineering; translational research

(This special issue belongs to the Section Molecular Biology)

Advances in Autoimmune Diseases: The Molecular Basis and New Therapies

edited by

Adawi Mohammad

submission deadline 31 Dec 2025 | Viewed by 123 | Submission Open

Keywords: autoimmunity; molecular mechanisms; biologics; immunotherapy; precision medicine

(This special issue belongs to the Section Molecular Immunology)

Anti-Cancer Effects of Natural Products: 2nd Edition

edited by

Moon Nyeo Park

submission deadline 31 Dec 2025 | Viewed by 122 | Submission Open

Keywords: cancer; natural products; herbal medicine; anticancer therapies; metastasis; recurrence; resistance mechanism; novel biomarker

(This special issue belongs to the Section Molecular Pharmacology)

Pathogenesis of Central Nervous System Disorders, Interplay and Multifaceted Role of Glial Cells and Neuroprotective Mechanisms

edited by Matilde Balbi

submission deadline 31 Dec 2025 | Viewed by 122 | Submission Open

Keywords: neurodegenerative disease; CNS disorders; glial cells; glia-cross talk; extracellular vesicles; calcium pathway; neuroinflammation; autophagy; excitotoxicity; glial phenotype

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Biochemical, Genetic, and Molecular Biology Approaches in Human Reproduction

edited by Athanasios Zikopoulos

submission deadline 31 Dec 2025 | Viewed by 121 | Submission Open

Keywords: reproductive biology; infertilit; epigenetics in reproduction; maternal-fetal health; precision medicine

(This special issue belongs to the Section Molecular Biology)

Cell Penetrating Peptides: Novel Therapeutic Tools for Drug Delivery

edited by

Betty Revon Liu

submission deadline 31 Dec 2025 | Viewed by 121 | Submission Open

Keywords: cell-penetrating peptides; peptide design; drug delivery; controlled and release; clinical applica-tions; penetration mechanisms

(This special issue belongs to the Section Molecular Pharmacology)

Phytochemical Insights and Green Extraction Strategies for Bioactive Natural Compounds

edited by

Ana M. L. Seca

and

Gonçalo Pereira da Rosa

submission deadline 31 Dec 2025 | Viewed by 120 | Submission Open

Keywords: plant and algal bioactive metabolites; phytochemistry; green extraction techniques; natural sustainable solvents (NADES); structural elucidation of natural molecules; molecular characterization

(This special issue belongs to the Section Bioactives and Nutraceuticals)

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