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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Focus on Plant Biotechnology and Molecular Breeding submission deadline 31 Dec 2025 | 3 articles | Viewed by 1469 | Submission Open
Keywords: genetic engineering; plant transformation; applied biotechnology; functional genomics; crop plants; crop improvement; plant tissue cultures; secondary metabolites
(This special issue belongs to the Section Molecular Plant Sciences)
Melanoma: From Molecular Pathology to Therapeutic Approaches, 2nd Edition
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1451 | Submission Open
Keywords: melanoma; pathology; therapeutic approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Research of Plant-Pathogen Interaction
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1409 | Submission Open
Keywords: molecular plant-pathogen interactions; pathogen detection; secondary metabolism; multi-omics approaches; antibiotic resistance
(This special issue belongs to the Section Molecular Plant Sciences)
Food Allergy: Molecular Mechanisms, Clinical Challenges, and Future Directions
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1229 | Submission Open
Keywords: food allergy; allergen; environmental exposures; gut microbiome; non-IgE-mediated pathways
(This special issue belongs to the Section Molecular Immunology)
Molecular Biology of Human Reproduction
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1219 | Submission Open
Keywords: human reproduction; genomics; transcriptomics; proteomics; imaging technologies
(This special issue belongs to the Section Molecular Biology)
Advances in Forensic Molecular Biology and Genetics
edited by
submission deadline 31 Dec 2025 | Viewed by 1152 | Submission Open
Keywords: nuclear and mt-DNA; rapid DNA analysis; next-generation sequencing; mRNA analysis; microbiome analysis; barcode DNA; time since deposition; fluid identification; DNA phenotyping; DNA ancestry
(This special issue belongs to the Section Molecular Biology)
Nature-Inspired and Synthetic Compounds: New Frontiers in Bioactivity and Drug Discovery
edited by and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1149 | Submission Open
Keywords: natural and synthetic products; drug discovery and development; drug repurposing; artificial intelligence and machine learning; biological evaluation; healthcare; green and sustainable chemistry; natural and synthetic drug applications
(This special issue belongs to the Section Bioactives and Nutraceuticals)
25th Anniversary of IJMS: Updates and Advances in Molecular Pharmacology
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1082 | Submission Open
Keywords: precision medicine; pharmacogenomics; targeted protein degradation (TPD); molecular pharmacology; RNA Therapeutics; novel drug modalities; proteomics; transcriptomics; personalized drug therapy
(This special issue belongs to the Section Molecular Pharmacology)
Advances in Inflammasomes
edited by
submission deadline 31 Dec 2025 | Viewed by 1052 | Submission Open
Keywords: inflammasome; pyroptosis; innate immunity; cancer; neurodegenerative diseases; microbiota; gasdermin; ninjurin; drug screening; personalized treatments; multi-omics analysis
(This special issue belongs to the Section Molecular Immunology)
Upcycling Food Industry By-Products: Bioactive Ingredients for Nutrition and Health submission deadline 31 Dec 2025 | 1 articles | Viewed by 991 | Submission Open
Keywords: bioactive compounds; food by-products; functional foods; molecular mechanisms; polyphenols; oxidative stress; inflammation; nutrigenomics; microbiome; prebiotics; postbiotics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Trends in Alzheimer’s Disease Research: From Molecular Mechanisms to Therapeutics: 3rd Edition
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 920 | Submission Open
Keywords: Alzheimer’ s disease; pathogenic mechanisms; genomics; epigenetics; biomarkers; prevention; treatment; pharmacogenetics
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Breeding for Important Economic Traits in Livestock submission deadline 31 Dec 2025 | Viewed by 883 | Submission Open
Keywords: molecular breeding; livestock genetics; economic traits; genomic selection; adipogenesis; feed efficiency; disease resistance; non-coding RNAs; multi-omics; genetic improvement
(This special issue belongs to the Section Molecular Biology)
Atherosclerosis and Comorbidities: From Molecular Pathogenesis to Diagnosis and Therapeutic Targets submission deadline 31 Dec 2025 | Viewed by 843 | Submission Open
Keywords: atherosclerosis; comorbidities; lipidology; inflammation; obesity; arterial stiffness; vascular remodeling; cardiovascular risk; cardiovascular diseases; targeted therapies; lifestyle
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Emerging Trends in Enzymology submission deadline 31 Dec 2025 | Viewed by 807 | Submission Open
(This special issue belongs to the Section Biochemistry)
Enzymes and Enzyme Inhibitors—Applications in Medicine and Diagnosis, 3rd Edition
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 797 | Submission Open
Keywords: enzyme; enzyme inhibitor; drug target; enzyme deficiency; enzyme overexpression; biomarker; drugs; diagnosis; therapy
(This special issue belongs to the Section Molecular Pharmacology)
Red Blood Cells: Dynamic Regulators, Disease Indicators and Therapeutic Targets
edited by Leonid Livshits
submission deadline 31 Dec 2025 | 1 articles | Viewed by 734 | Submission Open
Keywords: red blood cell (RBC); RBC biochemical; hemodynamic; biophysical properties
(This special issue belongs to the Section Molecular Biology)
Advances in the Synthesis and Study of Novel Bioactive Molecules submission deadline 31 Dec 2025 | 1 articles | Viewed by 709 | Submission Open
Keywords: organic compounds; metal complexes; bioactive molecules
(This special issue belongs to the Section Biochemistry)
Recent Advances in Molecular Research and Therapeutic Strategies for Endometrial Cancer
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 704 | Submission Open
Keywords: endometrial cancer; molecular classification; biomarkers; precision medicine; targeted therapy; immunotherapy; early detection; non-invasive diagnostics; genomic profiling; translational research
(This special issue belongs to the Section Molecular Oncology)
Microbial Fermentation: Advances in Synthetic Biology, Metabolic Engineering, and Biomanufacturing
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 693 | Submission Open
Keywords: microbial fermentation; synthetic biology; metabolic engineering; biomanufacturing; industrial biotechnology
(This special issue belongs to the Section Molecular Microbiology)
Molecular Insights into Plasma in Seed and Plant Treatment submission deadline 31 Dec 2025 | Viewed by 672 | Submission Open
Keywords: seed; plant; plasma; germination; dormancy; sterilization; reactive oxygen species; reactive nitrogen species; molecular mechanism; growth promotion; essential oils; plant stem cells; seed coating and pelleting
(This special issue belongs to the Section Molecular Plant Sciences)
Chelating Ligands in Therapeutics: Recent Advances and Future Directions submission deadline 31 Dec 2025 | Viewed by 635 | Submission Open
Keywords: metal complexes; chelation therapy; chelating agents; diagnostic imaging; metal detoxification; chelation pharmacokinetics
(This special issue belongs to the Section Biochemistry)
Advances in Plant RNA Biology: Non Coding RNAs in Plant Development, Defense, and Adaptation
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 630 | Submission Open
Keywords: plant RNA biology; regulatory RNA; non-coding RNA; small RNA (including miRNAs and siRNAs); RNA interacting proteins; plant development; plant pathogen defense; plant environmental stress adaptation
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms and Therapeutic Strategies for Pregnancy Complications
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 618 | Submission Open
Keywords: pregnancy complications; placenta diseases; molecular mechanisms; therapeutics; biomarkers; preeclampsia; gestational diabetes; intrauterine growth restriction; maternal-fetal exchange; inflammation mediators
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancing Research on Alexander Disease
edited by
submission deadline 31 Dec 2025 | Viewed by 614 | Submission Open
Keywords: Alexander disease; astrocyte dysfunction; intermediate filaments; GFAP; astrogliosis; neurodegeneration; leukodystrophy; rare disease; rosenthal fibers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bacterial Infections: Unraveling Pathogenesis, Resistance, and Therapeutic Frontiers
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 599 | Submission Open
Keywords: antimicrobial resistance; host– pathogen interactions; bacterial molecular pathogenesis; therapeutic target discovery
(This special issue belongs to the Section Molecular Microbiology)
Carbon Fiber, Carbon Nanofiber for Composites: Synthesis, Processing, Molecular Structure, Characterization, and Application
edited by Tridung Ngo
submission deadline 31 Dec 2025 | Viewed by 589 | Submission Open
Keywords: carbon fiber; carbon nanofiber; nanotube; carbon fiber composites; synthesis; advanced manufacturing; characterization; recent advancements; applications
(This special issue belongs to the Section Materials Science)
Targeted Pharmacological Modulation of Cellular Pathology and Drug Discovery: A Translational Approach to Bridge Laboratory Discoveries with Clinical Practice
edited by Saurav Mallik
submission deadline 31 Dec 2025 | 1 articles | Viewed by 585 | Submission Open
Keywords: targeted pharmacotherapy; cellular pathology; translational medicine; drug mechanism of action; signal transduction modulation; precision medicine; apoptosis and autophagy; biomarker-guided therapy; pathophysiology-driven drug design; clinical applications of molecular targets; molecular docking
(This special issue belongs to the Section Molecular Pharmacology)
T-Cell Lymphoma: From Basic Science to Novel Therapeutics submission deadline 31 Dec 2025 | Viewed by 572 | Submission Open
Keywords: T-cell lymphoma; targeted therapy; immunotherapy; translational research; real-world experience
(This special issue belongs to the Section Molecular Oncology)
Emerging Trends of Quantum Mechanics, Computational Chemistry, and Spectroscopy in Physical Chemistry
edited by
submission deadline 31 Dec 2025 | Viewed by 567 | Submission Open
Keywords: quantum theory; computational chemistry; spectroscopy
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular Dynamics Techniques in the Artificial Intelligence Era
edited by , and Itamar Borges Junior
submission deadline 31 Dec 2025 | Viewed by 566 | Submission Open
Keywords: molecular dynamics; machine learning; force field; free energy; statistical mechanics; algorithm development; artificial intelligence
(This special issue belongs to the Section Molecular Informatics)
Supramolecular Liquid Crystal Compounds—from Molecular Design to Functional Materials
edited by
submission deadline 31 Dec 2025 | Viewed by 563 | Submission Open
Keywords: supramolecular; self-assembled; liquid crystal; hydrogen bonding
(This special issue belongs to the Section Materials Science)
Molecular Entomology of Insects of Economic Importance: Advanced Molecular Approaches for Insect Pest Management
edited by
submission deadline 31 Dec 2025 | Viewed by 525 | Submission Open
Keywords: molecular entomology; insect pests; agricultural pests; disease vectors; beneficial insects; CRISPR; RNA interference; genome-wide approaches; computational biology; nanotechnology
(This special issue belongs to the Section Molecular Biology)
Molecular Research on the Pathology and Treatment of Sepsis and Non-Infectious Inflammatory Conditions
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 511 | Submission Open
Keywords: sepsis; comorbidities; inflammation; molecular mechanisms; cytokine signaling; oxidative stress; leukocyte recruitment; therapeutic targets
(This special issue belongs to the Section Molecular Immunology)
State-of-the-Art Electrochemical Reaction Technologies submission deadline 31 Dec 2025 | 1 articles | Viewed by 510 | Submission Open
Keywords: energy storage; electrochemical sensors; electrocatalysis; supercapacitors; molecular electrochemistry
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Design of Polymer Composites for Biomedical Applications
edited by
submission deadline 31 Dec 2025 | Viewed by 507 | Submission Open
Keywords: biocompatibility; polymers; biomaterials; tissue regeneration; mesenchymal cells; wound healing
(This special issue belongs to the Section Materials Science)
Role of Mesenchymal Stem/Stromal Cells (MSCs) in Human Diseases and Their Treatment
edited by
submission deadline 31 Dec 2025 | Viewed by 506 | Submission Open
Keywords: mesenchymal stem/stromal cells (MSCs); MSC homing; MSC properties; immune cells; macrophages; injury; inflammation; cell therapy
(This special issue belongs to the Section Molecular Immunology)
Current Progress in Neutrophil Extracellular Traps (NETs)
edited by
submission deadline 31 Dec 2025 | Viewed by 471 | Submission Open
Keywords: PAD4; NETs; autoimmune diseases; CECNs; autoantibodies
(This special issue belongs to the Section Molecular Immunology)
Natural Products and Drug Delivery Systems in Dental Diseases submission deadline 31 Dec 2025 | 1 articles | Viewed by 415 | Submission Open
Keywords: periodontitis; natural products; anti-inflammatory therapy; local drug delivery; gingival inflammation; regenerative periodontics; nanotechnology in dentistry; herbal medicine; antimicrobial agents; oral microbiome modulation; signaling pathways
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Tools in Environmental Microbiology submission deadline 31 Dec 2025 | Viewed by 393 | Submission Open
Keywords: environmental microbiology; molecular methods; microbial community analysis; low-abundance microorganisms; microbial identification; environmental DNA; next-generation sequencing (NGS); high-throughput sequencing
(This special issue belongs to the Section Molecular Microbiology)
Detrimental and Beneficial Roles of Glial Cells After Neural Disorders
edited by
submission deadline 31 Dec 2025 | Viewed by 388 | Submission Open
Keywords: neuroprotection; neuroinflammation; cell therapy; microglia; astrocytes; oligodendrocytes; Janus face; double-edged sword
(This special issue belongs to the Section Molecular Neurobiology)
Microbial Metagenomics: From Basic Science to Biotechnological Applications
edited by Rafael Antonio Rojas-Herrera
submission deadline 31 Dec 2025 | Viewed by 368 | Submission Open
Keywords: metagenomic; microbial ecology; bioremediation; ecological resilience; extremozyme bioprospecting; biodiversity
(This special issue belongs to the Section Molecular Microbiology)
Functional Genomics and Molecular Mechanisms of Plant Stress Responses
edited by
submission deadline 31 Dec 2025 | Viewed by 356 | Submission Open
Keywords: plant stress responses; abiotic stress; biotic stress; molecular mechanisms; functional genomics
(This special issue belongs to the Section Molecular Plant Sciences)
Functional Microbiomes and the Organization of Marine Communities: Molecular Biological Insights
edited by
submission deadline 31 Dec 2025 | Viewed by 355 | Submission Open
Keywords: marine communities; functional microbiomes; exoenzymes; chemical communication; organization of complex ecosystems
(This special issue belongs to the Section Molecular Microbiology)
Advances in Pathophysiology and Treatment of Atherosclerosis
edited by Graziano Riccioni
submission deadline 31 Dec 2025 | Viewed by 318 | Submission Open
Keywords: atherosclerosis; pathogenetic pathway; targeted therapies; cardiovascular disease; plaque development
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Medicinal Plants in Drug Discovery: Unveiling Potential Applications and Molecular Mechanisms
edited by Abdelhakim Bouyahya
submission deadline 31 Dec 2025 | Viewed by 313 | Submission Open
Keywords: bioactive compounds; pharmacodynamic; clinical efficacy; chemotherapeutic drugs
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Research on Prostate Cancer, 2nd Edition
edited by
submission deadline 31 Dec 2025 | Viewed by 298 | Submission Open
Keywords: prostate cancer; molecular biology; genomics; biomarkers; signaling pathways; precision medicine; treatment resistance; epigenetics; therapeutic targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Macrophage Plasticity: Beyond the M1–M2 Paradigm
edited by
submission deadline 31 Dec 2025 | Viewed by 250 | Submission Open
Keywords: macrophage; plasticity; microenvironment; polarization; epigenetic modulation; phagocytosis
(This special issue belongs to the Section Molecular Immunology)
Advances in Drug Synthesis Reactions: From Bench to Breakthroughs
edited by
submission deadline 31 Dec 2025 | Viewed by 236 | Submission Open
Keywords: organic synthesis; sustainability; scale-up synthesis; bio-orthogonal reactions; flow chemistry; green chemistry; natural product scaffolds; electrochemical synthesis; chemoenzymatic synthesis; automated and high-throughput synthesis
(This special issue belongs to the Section Molecular Pharmacology)
Advances in Dendritic Cell-Based Immunotherapy of Cancer
edited by Helena Haque Chowdhury and Matjaz Jeras
submission deadline 31 Dec 2025 | Viewed by 229 | Submission Open
Keywords: DC-based immunotherapy of cancer; immunostimulatory dendritic cell (DC) generation; dosage and routes of DC administration; body distribution of DCs post-application; frequency and duration of DC applications; tumour immunosuppressive mechanisms’ modulation; combinatorial DC-based anticancer immunotherapy
(This special issue belongs to the Section Molecular Immunology)
Organoid Models in Host–Pathogen Interactions and Disease Pathogenesis
edited by
submission deadline 31 Dec 2025 | Viewed by 228 | Submission Open
Keywords: organoids; host– pathogen interaction; infectious disease models; mucosal immunity; tissue engineering; microbial pathogenesis; immune organoids; 3D culture systems
(This special issue belongs to the Section Molecular Biology)
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