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Molecular Research on Prostate Cancer, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 September 2026 | Viewed by 1229

Special Issue Editor


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Guest Editor
1. Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada
2. Departments of Oncology, Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada
3. Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada
Interests: prostate cancer; genomics; transcriptome; tumor biomarkers; tumorigenesis
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Special Issue Information

Dear Colleagues,

Prostate cancer represents a significant global health challenge, with a demand for improved patient outcomes. Despite treatment strategy advancements, the molecular complexity of this disease remains a daunting hurdle. Understanding the molecular mechanism driving prostate cancer initiation, progression and therapeutic resistance is pivotal for developing precise and effective interventions.

This Special Issue aims to consolidate the latest findings and perspectives on the molecular landscape of prostate cancer, genomic alterations, epigenetic modifications, signaling pathways and novel biomarkers. We aim to foster a collaborative platform for researchers to contribute transformative insights that can shape the future of prostate cancer management and provide a comprehensive overview of the latest breakthroughs in the field. Authors are invited to contribute research articles elucidating the molecular intricacies underlying prostate cancer, fostering a deeper comprehension that can shape relevant targeted therapies and precision medicine.

Dr. Yaser Gamallat
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • prostate cancer
  • molecular biology
  • genomics
  • biomarkers
  • signaling pathways
  • precision medicine
  • treatment resistance
  • epigenetics
  • therapeutic targets

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Related Special Issue

Published Papers (1 paper)

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Review

16 pages, 1252 KB  
Review
Significance of EVs in Prostate Cancer Bone Metastases
by Kagenori Ito, Takaaki Tamura, Fumihiko Urabe, Shinichi Sakamoto, Takahiro Kimura, Shin Egawa and Takahiro Ochiya
Int. J. Mol. Sci. 2025, 26(24), 12160; https://doi.org/10.3390/ijms262412160 - 18 Dec 2025
Viewed by 711
Abstract
Prostate cancer (PCa) exhibits a unique propensity to metastasize to bone, where it predominantly generates osteoblastic lesions. The formation of these lesions is a complex and dynamic process driven by reciprocal interactions between tumor cells and the bone microenvironment. Emerging evidence indicates that [...] Read more.
Prostate cancer (PCa) exhibits a unique propensity to metastasize to bone, where it predominantly generates osteoblastic lesions. The formation of these lesions is a complex and dynamic process driven by reciprocal interactions between tumor cells and the bone microenvironment. Emerging evidence indicates that extracellular vesicles (EVs) play pivotal roles in the establishment of metastatic colonies and disease progression, as well as in local tumor–bone interactions. Through their diverse cargos, including proteins, lipids, and non-coding RNAs, EVs mediate bidirectional communication that regulates osteoclastogenesis, osteoblast activation, and osteocyte function, ultimately reshaping the bone niche to favor tumor growth. Importantly, EVs exhibit dual and context-dependent functions, acting either as promoters or suppressors of malignancy depending on the cellular source and microenvironmental context. These insights highlight EVs not only as mechanistic drivers of PCa bone metastases but also as promising therapeutic targets. Approaches aimed at modulating EV biogenesis, eliminating deleterious EVs, or harnessing EVs as drug delivery vehicles hold significant potential for advancing treatment strategies against PCa bone metastases. Full article
(This article belongs to the Special Issue Molecular Research on Prostate Cancer, 2nd Edition)
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