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Molecular Biology of Human Reproduction

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 813

Special Issue Editor

Biochemistry and Molecular Biology of Reproductive Medicine Laboratory, Saarland University, 66421 Homburg, Germany
Interests: human molecular biology; reproductive medicine; human reproduction; embryology; andrology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue invites submissions that explore the molecular mechanisms of human reproduction. Recent advances in genomics, transcriptomics, proteomics, and imaging technologies have revolutionized our understanding of reproductive biology, allowing us to gain a deeper understanding of the cellular and molecular processes of gametogenesis, fertilization, implantation, and early embryonic development. These discoveries hold promise for addressing key challenges in reproductive health, including infertility, miscarriage, and congenital diseases.

This issue aims to compile high-quality studies and reviews on the basic molecular mechanisms of human reproductive function. We particularly welcome submissions on the regulation of gene expression in germ cells and embryos, the molecular regulation of meiosis, oocyte maturation and sperm function, epigenetic programming in early development, and signaling pathways in implantation and placenta formation. Studies using model systems are welcome, provided their relevance to human reproduction can be clearly demonstrated.

We also encourage interdisciplinary research that combines molecular biology with clinical research in reproductive medicine, including studies on the molecular basis of reproductive diseases such as polycystic ovary syndrome (PCOS), endometriosis, and unexplained infertility. We also particularly welcome submissions focusing on novel diagnostic biomarkers or therapeutic targets.

This Special Issue aims to provide a comprehensive resource for researchers and clinicians, promote interdisciplinary dialog, and support translational applications to improve reproductive outcomes. We welcome your contributions to advance the molecular science of human reproduction.

Dr. Houda Amor
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • human reproduction
  • genomics
  • transcriptomics
  • proteomics
  • imaging technologies

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Published Papers (1 paper)

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Research

23 pages, 10573 KB  
Article
Exposure to Bisphenol B and S Increases the Risk of Male Reproductive Dysfunction in Middle Age
by Sen Zhao, Heliang Ni, Yuan Xiao, Jing Du, Yudong Han, Wenying Wang, Shuang Tang and Mingxi Yu
Int. J. Mol. Sci. 2025, 26(19), 9507; https://doi.org/10.3390/ijms26199507 - 28 Sep 2025
Viewed by 646
Abstract
Accumulating evidence indicates that bisphenol A (BPA) analogs, including bisphenol B (BPB) and bisphenol S (BPS), disrupt testicular function and contribute to male reproductive dysfunction (MRD). However, whether BPA analogs are involved in MRD among middle-aged men remains inconclusive. Therefore, we selected cryptorchidism, [...] Read more.
Accumulating evidence indicates that bisphenol A (BPA) analogs, including bisphenol B (BPB) and bisphenol S (BPS), disrupt testicular function and contribute to male reproductive dysfunction (MRD). However, whether BPA analogs are involved in MRD among middle-aged men remains inconclusive. Therefore, we selected cryptorchidism, erectile dysfunction, premature ejaculation, and testicular tumors as representative MRD conditions in middle-aged individuals, aiming to explore the molecular mechanisms that may be disrupted by bisphenols (BPs). By using GeneCards, STRING and Cytoscape, TP53, AKT1, and MYC were pinpointed as core targets associated with MRD. Enrichment analysis suggested that BPs may induce MRD by disrupting steroidogenesis. UPLC-MS/MS analysis showed that both BPB and BPS exhibit specific accumulation in the testes. Following 20-day exposure to 0.3 or 0.6 mg/kg body weight/day BPB or BPS, testosterone levels and the expression of hub genes were decreased. The molecular docking results demonstrated that both BPB and BPS can directly bind to members of the cytochrome P450 family, potentially interfering with sex hormone biosynthesis. Our study identified the targets and mechanisms through which BPB and BPS induce MRD in middle-aged males, thereby providing insights for the safety assessment of BPs. Full article
(This article belongs to the Special Issue Molecular Biology of Human Reproduction)
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