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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances and Emerging Trends in Marine Natural Products

edited by Rafael Alexandre Faria da Costa Félix and

Carina Félix

submission deadline 20 Jan 2026 | 3 articles | Viewed by 4093 | Submission Open

Keywords: marine natural products; bioprospecting; circular bioeconomy; bioactive compounds; antioxidant; antimicrobial; anti-inflammatory; polymers; peptides; genome mining; enzyme inhibitors; plant priming; green extraction methodologies

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insights into Lipodystrophy

edited by

Sofía Sánchez-Iglesias

and

David Araújo-Vilar

submission deadline 20 Jan 2026 | 2 articles | Viewed by 4046 | Submission Open

Keywords: lipodystrophy; adipogenesis; animal models; lipid metabolism; therapeutic targets; insulin signaling pathways; adipose tissue

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Artificial Intelligence in Cancer Treatment: Molecular Perspective

edited by Andra Valentina Krauze

submission deadline 20 Jan 2026 | 2 articles | Viewed by 4009 | Submission Open

Keywords: cancer treatment; artificial intelligence; machine learning; precision medicine; molecular insights

(This special issue belongs to the Section Molecular Informatics)

Hormone Metabolism and Signaling in Human Health and Disease

edited by

Kuo-Hu Chen

submission deadline 20 Jan 2026 | 1 articles | Viewed by 3980 | Submission Open

Keywords: hormone metabolism; signaling pathways; pathophysiology; molecular and cellular biology; diseases originating from hormone disorders; hormonal therapy

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Exploring the Complex Interplay Between Metabolic Diseases, MASLD, and Liver Cancer

edited by

Daniela Gabbia

and

Sara De Martin

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3951 | Submission Open

Keywords: hepatocellular carcinoma; MASLD; MASH; obesity; insulin resistance; dyslipidemia; liver cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pathophysiology and Treatment of Congenital Neuromuscular Disorders

edited by Johan Lindqvist

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3737 | Submission Open

Keywords: nemaline myopathy; hereditary neuromuscular disorder; genetic mutations; pathogenesis; pathophysiology; therapy; myofilament dysfunction; congenital neuromuscular disorders; congenital muscular dystrophy; spinal muscular atrophy; Duchenne muscular dystrophy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hemophilia: From Pathophysiology to Novel Therapies

edited by

Mingching Shen

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3590 | Submission Open

Keywords: hemophilia; novel therapy in hemophilia; ultra-long half life clotting factor; clotting factor mimics; coagulation rebalancing agent; gene therapy; pathogenesis of hemophilia; molecular biology of hemophilia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of HLA (Human Leucocyte Antigen) in Human Diseases

edited by

Jeane Eliete Laguila Visentainer

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3514 | Submission Open

Keywords: HLA (human leukocyte antigen); molecular immunology; autoimmune diseases; HLA genetics; antigen presentation; HLA and cancer; immunotherapy and HLA; immune responses; immunity and HLA; infectious diseases and HLA; innate and adaptive immunity; organ transplantation and HLA; HLA and immune responses; HLA genotypes and susceptibility; autoimmunity and HLA; HLA and infectious diseases; HLA and personalized therapies; molecular mechanisms of HLA; HLA mutations; experimental models of HLA; HLA and inflammation; HLA biomarkers; HLA and immunosuppression; immune tolerance and HLA; immune evasion by HLA

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biology and Targeted Therapies in Leukemias

edited by Fabio Stagno and

Stefania Stella

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3418 | Submission Open

Keywords: molecular biology; target therapy; leukemia; TKI; BCL-2; FLT3; CAR-T cells; CML

(This special issue belongs to the Section Molecular Oncology)

Current Research for Heart Disease Biology and Therapeutics (Third Edition)

edited by Claudia Kusmic

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3399 | Submission Open

Keywords: myocardial hypertrophy; cardiac remodeling; heart failure; drug therapy; molecular therapeutic targets; myocardial gene therapy; heart disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Lipid Peroxidation and Protein Carbonylation in Human Diseases

edited by

Galina Nikolova

submission deadline 20 Jan 2026 | 1 articles | Viewed by 3372 | Submission Open

Keywords: free radicals; lipid peroxidation; protein carbonylation; apoptosis; autophagy; ferroptosis; antioxidant enzymes

(This special issue belongs to the Section Biochemistry)

Molecular Targets in Gastrointestinal Diseases

edited by

Changwon Yang

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3365 | Submission Open

Keywords: molecular pathways; gastrointestinal cancers; inflammatory bowel disease; targeted therapies; microbiota; gene editing

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oxidative Stress Responses in Cardiovascular Diseases

edited by Vladimir Jakovljevic

submission deadline 20 Jan 2026 | 1 articles | Viewed by 3351 | Submission Open

Keywords: antioxidant capacity; cardiovascular disease; cell death; endothelial dysfunction; ischemia/reperfusion injury; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Plant Stress

edited by

Pandiyan Muthuramalingam

Subramani Pandian

and

Hyunsuk Shin

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3340 | Submission Open

Keywords: abiotic stress; biotic stress; bioinformatics; artificial intelligence; biotechnology; breeding; crop plants; horticultural plants; GWAS; CRISPR-Cas; multi-omics; genomics; epigenomics; transcriptomics; proteomics; genetic diversity; gene expression

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Advances in Understanding Plant-Microbe Interactions

edited by

Tomislav Radić

and

Katarina Hančević

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3288 | Submission Open

Keywords: phytomicrobiome; symbiosis; pathogen resistance; microbial signalling

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Clostridial and Related Neurotoxins, 3rd Edition

edited by

Sabine Pellett

submission deadline 20 Jan 2026 | 1 articles | Viewed by 3274 | Submission Open

Keywords: botulinum neurotoxin; BoNT; toxicity; molecular mechanisms; recombinant; derivative; clostridium botulinum

(This special issue belongs to the Section Molecular Toxicology)

Molecular Dynamics Simulations of Protein Structures

edited by Alfonso Trezza

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3241 | Submission Open

Keywords: molecular dynamics simulations; protein structure analysis; computational methods in structural biology; bioinformatics and drug discovery; protein– ligand interactions

(This special issue belongs to the Section Molecular Biophysics)

Genomics of Human Disease

edited by

Sungkyoung Choi

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3204 | Submission Open

Keywords: genome-wide association study (GWAS); next-generation sequencing (NGS); multi-omics analysis; epidemiology data analysis; precision medicine approaches; disease prediction analysis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Hematologic Diseases: Molecular Insights and Novel Methods

edited by

Simona Soverini

and Samantha Bruno

submission deadline 20 Jan 2026 | 1 articles | Viewed by 3192 | Submission Open

Keywords: hematologic malignancies; high-throughput technologies; omics data; biomarkers; drug resistance; minimal residual disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular Research of Cartilage: 2nd Edition

edited by

Laura Mangiavini

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2986 | Submission Open

Keywords: articular cartilage; cartilage lesions; tissue engineering; cell therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms: New Insights into the Pathogenesis of Neonatal Disorders

edited by

Rozeta Sokou

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2959 | Submission Open

Keywords: neonate; neonatal infections; molecular and cellular mechanisms; necrotizing enterocolitis; immature immune system; neonatal inflammation; epigenetic modification; regulatory RNAs; bronchopulmonary dysplasia; neonatal hypoxic– ischemic injury

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancing Precision Medicine in Urological Cancers: Integrating Multi-Omics and Optimizing Therapeutic Approaches

edited by Magaly Martinez-Ferrer

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2920 | Submission Open

Keywords: prostate cancer; proteomics; metabolomics; precision medicine; biomarker

(This special issue belongs to the Section Molecular Oncology)

Psoriasis: Molecular Pathologies, Lipid Disturbances, Diagnosis and Therapeutic Strategies

edited by Hanna Mysliwiec

submission deadline 20 Jan 2026 | 3 articles | Viewed by 2871 | Submission Open

Keywords: psoriasis; pathogenesis; lipid metabolism disturbances; metabolic syndrome; systemic comorbidities; epigenetics; therapeutic strategies; biologic treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cell Envelope Biogenesis and, Molecular Strategies to Maintain Cellular Homeostasis in Bacteria

edited by

Satish Raina

and

Gracjana Klein

submission deadline 20 Jan 2026 | 3 articles | Viewed by 2793 | Submission Open

Keywords: LpxC and the regulation of LPS; periplasmic protein folding; disulfide bond formation; BAM proteins and assembly of outer membrane proteins; periplasmic protease DegP (HtrA); lipopolysaccharide assembly; LPS modifications and diversity; LPS and phospholipid trafficking; bacterial virulence factors; antibiotic resistance; extracytoplasmic function sigma factors; regulatory RNAs; two-component systems; lipid A and its modification

(This special issue belongs to the Section Molecular Microbiology)

Dysregulation of Bone Health–a Matter of Several Culprits

edited by Ana Gomes

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2743 | Submission Open

Keywords: bone metabolism; osteoporosis; osteopenia; low-impact fractures; osteoimmunology; leptin; lung disorders; cancer; renal disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Chronic Lymphocytic Leukemia: Molecular Pathologies and Therapeutic Strategies

edited by Tang Her Jaing

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2739 | Submission Open

Keywords: chronic lymphocytic leukemia; genomic landscapes; precision medicine; clinical trials; biomarker

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microbial Resistance Mechanisms in Biotechnology: From Extremes to Applications

edited by Giovanni Gallo and

Martina Aulitto

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2708 | Submission Open

Keywords: microorganism resistance systems; extreme environments; molecular adaptation; genetic pathways; biotechnological applications; industrial biotechnology; environmental remediation; extremophiles; stress tolerance; evolutionary adaptations

(This special issue belongs to the Section Molecular Microbiology)

Exploring New Field in Hydrocolloids Research and Applications

edited by

Mihaela Violeta Ghica

, Cristina Elena Dinu-Pirvu and

Lacramioara Popa

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2693 | Submission Open

Keywords: drug delivery systems; controlled-release; targeted delivery; wound healing; tissue engineering; bioadhesive agents; transdermal patches; mucoadhesive hydrogels; ophthalmic preparations; oral disintegrating films; gastroretentive systems; rheology modifiers; textural characteristics; stabilizing agents; encapsulation for protection and stability (drugs; probiotics and bioactive compounds); 3D bioprinting; nutraceutical delivery

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

The Multiple Faces of Non-Small Cell Lung Cancer: Targeted Therapies and Recent Developments

edited by Angelo Delmonte and Alberto Verlicchi

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2648 | Submission Open

Keywords: non-small cell lung cancer; tyrosine-kinase inhibitors; next generation sequencing; immunoconjugates; targeted therapies

(This special issue belongs to the Section Molecular Oncology)

Molecular Research in Epilepsy and Epileptogenesis—2nd Edition

edited by

Stanisław Jerzy Czuczwar

and Barbara Miziak

submission deadline 20 Jan 2026 | 3 articles | Viewed by 2645 | Submission Open

Keywords: epilepsy; antiseizure; anti-epileptogenic drugs; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Innovative Strategies in the Design and Development of Anticancer Agents

edited by Sanjay Kumar

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2633 | Submission Open

Keywords: chemotherapy; biomimetic; natural product analogs; prodrugs; nanodrugs; drug release

(This special issue belongs to the Section Molecular Pharmacology)

Bone Development and Regeneration—4th Edition

edited by

Kazuo Yudoh

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2605 | Submission Open

Keywords: osteoblast; osteocyte; osteoclast; mesenchymal stem cell; cell differentiation; epigenetics; omics; integrative analysis; biomaterials

(This special issue belongs to the Section Molecular Biology)

Biofunctionalization of Metals for Medical Application: Molecular Aspects

edited by

Luca Scotti

and Xiaoming Zhang

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2603 | Submission Open

Keywords: biofunctionalization; medical applications; nanomaterials; nanofunctionalized materials; molecular mechanisms; bacterial membranes; membrane polarity; bacterial resistance

(This special issue belongs to the Section Molecular Nanoscience)

Autophagy and Kidney Diseases

edited by Francesco Reggiani

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2594 | Submission Open

Keywords: autophagy; kidney diseases; cellular homeostasis; molecular signaling; autophagy biomarkers; renal homeostasis; autophagy modulators

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Structure, Function and Dynamics in Proteins: 3rd Edition

edited by

Luigi Russo

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2584 | Submission Open

Keywords: protein structure and dynamics; protein– protein and protein– DNA interactions; protein folding and misfolding; protein aggregation processes; intermediate/misfolded states; conformational equilibria; DNA and ligand recognition mechanisms; membrane receptors; enzyme dynamics; metal-binding proteins; intrinsically disordered proteins; cell signaling; phase separation mechanims; solution- and solid-state NMR; molecular dynamics simulations; time-resolved X-ray; NMR relaxation; in-/on-cell NMR; cryo-EM; fluorescence polarization; surface plasmon resonance; static and dynamic light scattering; isothermal titration calorimetry; microscale thermophoresis; protein– fragment complementation assay; cross-linking; protein microarray

(This special issue belongs to the Section Molecular Biology)

Protein Networks and Their Signaling

edited by

Ashok Kumar

and

Vladimir N. Uversky

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2499 | Submission Open

Keywords: protein-protein interaction; chromatin/nucleosome; signaling; protein structure; drug design

(This special issue belongs to the Section Molecular Biology)

Latest Advances in Nanoparticles for Modern Biomedicine (2nd Edition)

edited by

Sebastian Schwaminger

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2456 | Submission Open

Keywords: nanoparticles; nanotherapeutics; nanomedicine; biomedicine; selective targeting of nanoparticles

(This special issue belongs to the Section Molecular Nanoscience)

Recent Advances in Molecular Mechanisms of Bacterial Resistance and Antibiotic Therapy

edited by

Xinyi Yang

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2451 | Submission Open

Keywords: bacterial resistance; antibiotics; antimicrobials; “ superbugs” ; clinical strains; laboratory induced-bacteria; antimicrobial peptides; antimicrobial combinations; hybrid antibiotics; repurposing drugs; anti-virulence agents; immune modulators; toxin neutralizers

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms of Bone Injury and Bone Tissue Regeneration

edited by Nasim Golafshan

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2348 | Submission Open

Keywords: bone formation; osteoblast diffrentiation; cell-based materials

(This special issue belongs to the Section Materials Science)

Precision Medicine Approaches to Antifibrotic Therapy

edited by Karim Daliri

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2227 | Submission Open

Keywords: fibrotic diseases; antifibrotic therapy; antifibrotic drug; multi-omics data; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research in Alzheimer’s Disease: Advances and Perspectives

edited by

Silvia Boschi

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2204 | Submission Open

Keywords: neuroinflammation; synaptic dysfunction; oxidative stress; neurofibrillary tangles; mitochondrial dysfunction; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Protein Signal Transduction in the Nucleus

edited by Jaekyung Shim

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2155 | Submission Open

Keywords: inner nuclear membrane protein; protein network; LEM-domain proteins; nuclear lamina; signal transcription; transcriptional regulation

(This special issue belongs to the Section Molecular Biology)

The Pathogenesis of Alcohol-Associated Hepatitis and Its Therapies

edited by

Mrigya Babuta

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2107 | Submission Open

Keywords: alcohol-associted hepatitis; acute kidney injury; hepatic encephalopathy; adaptive immune response; innate immune response; neutrophilia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Tumor Suppressor Proteins

edited by Jie Liu

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2060 | Submission Open

Keywords: DNA repair; genome stability; tumor suppressor; BRCA1; BRCA2; PALB2; RAD51C

(This special issue belongs to the Section Molecular Oncology)

Advanced Research on the Physiology and Toxicology of Aquatic Animals

edited by Xin Zhang

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2025 | Submission Open

Keywords: aquatic ecosystem; physiology of aquatic animals; toxicology of aquatic animals; environmental adaptability; environmental pollutants; ecotoxicology; biomarkers; risk assessment

(This special issue belongs to the Section Molecular Biology)

Role of Cell Metabolism in Cancer Biology

edited by

Silvia Filippi

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1967 | Submission Open

Keywords: cancer cells metabolism; target therapy; PI3K/Akt/mTOR pathway; hypoxia

(This special issue belongs to the Section Molecular Oncology)

Molecular Crosstalk in Breast Cancer Progression and Therapies

edited by Giuseppina Daniela Naimo

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1929 | Submission Open

Keywords: breast cancer; endocrine therapy; drug resistance; breast tumor microenvironment; targeted therapies; personalized therapies; immunotherapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oxidative Stress in Dermatology, Aesthetics and Regenerative Medicine

edited by

Eugenio Luigi Iorio

submission deadline 20 Jan 2026 | Viewed by 1918 | Submission Open

Keywords: oxidative stress; redox system; antioxidant chemical species; dermatology; aesthetics; regenerative medicine; inflammatory; degenerative skin diseases

(This special issue belongs to the Section Molecular Biology)

Molecular Breeding and Genetic Regulation of Crops, 2nd Edition

edited by

Chiara Biselli

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1891 | Submission Open

Keywords: molecular breeding; genetic regulation; genomics; genome-editing techniques; epigenetic modifications

(This special issue belongs to the Section Molecular Plant Sciences)

Modulating the Function of the Immune System by Thyrotropin and Thyroid Hormones

edited by Graciela Alicia Cremaschi and Claudia Gabriela Pellizas

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1870 | Submission Open

Keywords: thyrotropin (TSH); thyroid hormones (THs); immune modulation; immunology; immune; autoimmune; immunoendocrinology; hypothalamic-pituitary-thyroid axis; antitumor immune response

(This special issue belongs to the Section Molecular Immunology)

Displaying special issue 901-950 on page 19 of 65.

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