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Advanced Research on the Physiology and Toxicology of Aquatic Animals
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Advanced Research on the Physiology and Toxicology of Aquatic Animals

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 January 2026 | Viewed by 2331

Special Issue Editor

Dr. Xin Zhang

E-Mail Website
Guest Editor
College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
Interests: environmental physiology and toxicology of aquatic animals; healthy aquaculture

Special Issue Information

Dear Colleagues,

The physiology and toxicology of aquatic animals encompass the mechanism by which these organisms adapt physiologically to environmental changes and the impacts of pollutants on their health. With the increasing challenges posed by global environmental changes and water pollution, studying the physiological responses and toxicological effects of aquatic animals has become crucial for protecting aquatic ecosystems, assessing environmental risks, and promoting the sustainable development of the aquaculture industry.

We invite global researchers to submit original research articles, review papers, and short communications that are related, but not limited to, the following topics: (1) physiological responses of aquatic animals to environmental pollutants; (2) toxicological research methodologies in aquatic animals; (3) development and application of biomarkers for assessing aquatic animal health; (4) physiological adaptation mechanisms of aquatic animals under different environmental conditions; and (5) ecotoxicology of aquatic animals and its impacts on ecosystems.

This Special Issue aims to stimulate academic exchange and foster collaborative efforts in the field of aquatic animal physiology and toxicology, providing a platform for relevant research contributions. This special issue is supervised by Dr. Xin Zhang and assisted by Dr. Hongdan Wang.

Dr. Xin Zhang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aquatic ecosystem
  • physiology of aquatic animals
  • toxicology of aquatic animals
  • environmental adaptability
  • environmental pollutants
  • ecotoxicology
  • biomarkers
  • risk assessment

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Published Papers (2 papers)

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Research

20 pages, 9441 KB  
Article
Dietary Exposure to 2,2′,4,4′-Tetrabromodiphenyl Ether (BDE-47) Causes Inflammation in the Liver of Common Carp (Cyprinus carpio) and Affects Lipid Metabolism by Interfering with Steroid Hormone Biosynthesis Pathways
by Shuhuang Chen, Nian Han, Yujie Huang, Huimin Sun, Youlian Liu, Defang Chen, Zhiqiong Li and Xin Zhang
Int. J. Mol. Sci. 2025, 26(20), 10152; https://doi.org/10.3390/ijms262010152 - 18 Oct 2025
Viewed by 586
Abstract
2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) is a common environmental contaminant and widely detected in aquatic surroundings, while only a few reports exist on the hazard mechanism in economic aquatic animals. It has been shown that 40 and 4000 ng/g of BDE-47 dietary exposure over 42 [...] Read more.
2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) is a common environmental contaminant and widely detected in aquatic surroundings, while only a few reports exist on the hazard mechanism in economic aquatic animals. It has been shown that 40 and 4000 ng/g of BDE-47 dietary exposure over 42 days significantly increased the levels of blood triglycerides, glucose, and liver glycogen in carp (Cyprinus carpio). Tissue observations showed that BDE-47 resulted in vacuolation, atrophy, and fat deposition in hepatocytes. Combined metabolomic and transcriptomic analyses revealed that BDE-47 affected the inflammatory response and the biosynthesis of steroid hormones. This was further confirmed by gene expression related to inflammatory factors (il-10, tnf-α, il-1β, and tgf-β1), lipid metabolism (acc, fas, srebp, rxr, atgl, hsl, and lpl), and the steroid hormone biosynthetic pathway (11bhsd, hsd3b, and star). Thus, BDE-47 affects liver inflammatory response and lipid deposition through steroid hormone biosynthesis in carp. This helps us to understand how BDE-47 dietary exposure impacts inflammation and lipid metabolism in fish, which affects the health of aquaculture and has potential risks to human health. Full article
(This article belongs to the Special Issue Advanced Research on the Physiology and Toxicology of Aquatic Animals)
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25 pages, 7083 KB  
Article
Reproductive Risk Assessment of Bisphenol A and Its Substitutes on Estrogen Receptors (ERs) in Bivalves
by Weili Guo, Pengyu Zhang, Jianyong Song, Chunnuan Zhang and Ruiyi Xu
Int. J. Mol. Sci. 2025, 26(16), 7969; https://doi.org/10.3390/ijms26167969 - 18 Aug 2025
Cited by 2 | Viewed by 1021
Abstract
As benthic filter feeders, bivalve mollusks serve as ideal biological indicators. Bisphenol A (BPA) and its substitutes (BPS, BPF, and BPAF) are endocrine disruptors with reproductive toxicity, targeting estrogen receptors (ERs). However, their binding sites and affinity for shellfish ERs remain unclear. This [...] Read more.
As benthic filter feeders, bivalve mollusks serve as ideal biological indicators. Bisphenol A (BPA) and its substitutes (BPS, BPF, and BPAF) are endocrine disruptors with reproductive toxicity, targeting estrogen receptors (ERs). However, their binding sites and affinity for shellfish ERs remain unclear. This study aims to identify ER binding sites of BPA and its substitutes, compare toxicity via molecular docking, and validate results through exposure experiments. The full-length cDNA of Corbicula fluminea ER was cloned using the RACE technique for the first time, the sequence length is 2138bp. Homologous models of LBD sequences from Danio rerio, C. fluminea, Azumapecten farreri, and Ruditapes philippinarum ERs were constructed via homology modeling and screened for optimal fit. Hydrogen bonds were observed during the docking process, with interaction sites including Glu-66, Arg-177, and other amino acid residues. Exposure experiments (1, 10, and 100 μg/L) showed an enhancement in ER mRNA expression. Based on the docking energies and results of the exposure experiments, it was concluded that the toxicity of BPA and BPS is similar and greater than that of BPF and BPAF. This study provides data for a reproductive risk assessment and aquatic toxicological monitoring of bisphenols. Full article
(This article belongs to the Special Issue Advanced Research on the Physiology and Toxicology of Aquatic Animals)
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