Molecular Crosstalk in Breast Cancer Progression and Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 January 2026 | Viewed by 929
Special Issue Editor
Special Issue Information
Dear Colleagues,
Breast cancer is the most prevalent form of malignancy among women and the leading cause of cancer-related mortality among this demographic, representing a significant global health issue. Despite advances in early detection, molecular profiling, and treatment-improving outcomes, there is a high variability in prognosis and response to treatment in breast cancer patients due to the elevated heterogeneity of this disease. Several factors contribute to this variability, including the biology of the tumor, genetic mutations, tumor microenvironment, the stage at diagnosis, de novo or acquired resistance to treatment, and patient factors. Given this complexity, precision medicine is becoming increasingly important for improving outcomes for breast cancer patients. The identification of novel biomarkers and the understanding of the molecular mechanisms underlying different subtypes of breast cancer are key areas of current research. These efforts are critical for improving early detection, predicting prognosis, and developing more effective, personalized treatment strategies.
This Special Issue of the International Journal of Molecular Sciences, entitled "Molecular Crosstalk in Breast Cancer Progression and Therapies", aims to provide a comprehensive and up-to-date overview of the current state of knowledge concerning breast cancer's pathophysiology and molecular profiling. In addition, it will offer insights into the development of innovative targeted therapeutic approaches, focusing on the promises and potential limitations of these approaches.
Dr. Giuseppina Daniela Naimo
Guest Editor
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Keywords
- breast cancer
- endocrine therapy
- drug resistance
- breast tumor microenvironment
- targeted therapies
- personalized therapies
- immunotherapy
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