ijms-logo

Journal Browser

Journal Browser

Microbial Resistance Mechanisms in Biotechnology: From Extremes to Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 1044

Special Issue Editors


E-Mail Website
Guest Editor
Division of Microbiology, Faculty of Biology, Ludwig-Maximilians-Universität München, 82152 Martinsried, Germany
Interests: extremophiles; Thermus thermophilus; arsenic resistance systems; genome-editing tools; synthetic biology; β-aminoacidos

E-Mail Website
Guest Editor

Special Issue Information

Dear Colleagues,

Microorganisms thriving in extreme environments possess unique resistance systems that enable them to survive and function under harsh conditions such as extreme temperatures, pH levels, salinity and radiation. This Special Issue aims to explore the molecular and genetic mechanisms underlying these resistance systems, highlighting their evolutionary adaptations and physiological responses. The focus will be on identifying and characterizing essential resistance genes and pathways, as well as understanding the ways in which these microorganisms maintain stability and activity under extreme conditions. Additionally, the Special Issue will investigate the potential biotechnological applications of these resistance systems, including their use in industrial processes, environmental remediation and the development of novel bioproducts. By examining both the fundamental biology and applied aspects, this Special Issue seeks to provide comprehensive insights into the resilience of extremophiles and their potential to drive innovations in biotechnology.

Dr. Giovanni Gallo
Dr. Martina Aulitto
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microorganism resistance systems
  • extreme environments
  • molecular adaptation
  • genetic pathways
  • biotechnological applications
  • industrial biotechnology
  • environmental remediation
  • extremophiles
  • stress tolerance
  • evolutionary adaptations

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

20 pages, 2713 KiB  
Article
Bacterial Communities and Resistance and Virulence Genes in Hospital and Community Wastewater: Metagenomic Analysis
by Maria Elena Velazquez-Meza, Miguel Galarde-López, Patricia Cornejo-Juárez, Miriam Bobadilla-del-Valle, Ernestina Godoy-Lozano, Edgar Aguilar-Vera, Berta Alicia Carrillo-Quiroz, Alfredo Ponce de León-Garduño, Consuelo Velazquez Acosta and Celia Mercedes Alpuche-Aranda
Int. J. Mol. Sci. 2025, 26(5), 2051; https://doi.org/10.3390/ijms26052051 - 26 Feb 2025
Viewed by 632
Abstract
Metagenomic studies have made it possible to deepen the analysis of the abundance of bacterial populations that carry resistance and virulence determinants in the wastewater environment. In this study, a longitudinal collection of samples of community and hospital wastewater from August 2021 to [...] Read more.
Metagenomic studies have made it possible to deepen the analysis of the abundance of bacterial populations that carry resistance and virulence determinants in the wastewater environment. In this study, a longitudinal collection of samples of community and hospital wastewater from August 2021 to September 2022 was obtained. Shotgun metagenomic sequencing and bioinformatic analysis were performed to characterize the bacterial abundance, antimicrobial resistance genes (ARGs), plasmids, and virulence factor genes (VFGs) contained in the wastewater. The microbial composition of the community and hospital wastewater showed that the most abundant bacterial phyla detected in all samples were: Proteobacteria, Bacteroides, Firmicutes, Campylobacterota, and Actinobacteria. Seasonal differences in the relative abundances of species, ARGs, plasmids, and VFGs were observed. In this study, a total of 270 ARGs were detected, and it was found that the absolute abundance of ARGs only showed a 39% reduction in the treated wastewater. Furthermore, the ARGs detected in this study were found to encode resistance to antibiotics of the last choice. Our results showed that plasmids carrying resistance genes were more abundant in raw wastewater, and 60% more abundant in hospital wastewater compared to community wastewater. Several of the VFGs detected in this study encode for adhesion, motility, and biofilm formation, which likely allows bacteria to remain and persist in the wastewater environment and survive WWTP treatment systems, thus managing to escape into the environment via treated wastewater. Full article
Show Figures

Figure 1

Back to TopTop