Modulating the Function of the Immune System by Thyrotropin and Thyroid Hormones
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 20 July 2025 | Viewed by 625
Special Issue Editors
Interests: thyroid hormone; T-cell lymphoma; thyroxine; T-cell; hypothyroidism
Special Issue Information
Dear Colleagues,
Thyrotropin (TSH), a hormone produced by the pituitary gland, and thyroid hormones (THs), such as thyroxine (T4) and triiodothyronine (T3), primarily regulate metabolism and energy balance. However, emerging research highlights their significant influence on immune responses. TSH and THs interact with various immune cells, including T lymphocytes, B lymphocytes, macrophages, and dendritic cells, impacting their development, differentiation, and activity. The interplay between thyroid hormones and the immune system is crucial for maintaining immune homeostasis and responding to infections and autoimmune conditions. The dysregulation of thyroid hormone levels can lead to altered immune responses, contributing to the pathogenesis of autoimmune diseases such as Hashimoto’s thyroiditis and Graves’ disease.
Additionally, thyroid hormone imbalances are linked to increased susceptibility to infections, impaired vaccine responses, and affect the immune component of the tumor microenvironment, thus affecting tumor growth and dissemination. This Special Issue aims to collect research that explores the mechanisms through which TSH and THs influence immune function, their effects on various immune cell types, and the implications for pathology including autoimmune diseases and immunotherapy. By providing a comprehensive overview of the current understanding and highlighting novel insights, this Special Issue seeks to advance the field of immunoendocrinology and foster the development of therapeutic strategies targeting thyroid–immune system interactions.
Prof. Dr. Graciela Alicia Cremaschi
Prof. Dr. Claudia Gabriela Pellizas
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- thyrotropin (TSH)
- thyroid hormones (THs)
- immune modulation
- immunology
- immune
- autoimmune
- immunoendocrinology
- hypothalamic-pituitary-thyroid axis
- antitumor immune response
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
