Bone Development and Regeneration—4th Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 75
Special Issue Editor
Interests: articular cartilage; chondrocytes; polychondritis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The bone is a fascinating tissue conferring structural body support, mechanical integrity, and organ protection. A more holistic perspective sees the bone as an integral organ that, together with other tissues, not only regulates mineral homeostasis and maintains the hematopoietic niche but also plays endocrine functions, contributing to and regulating numerous metabolic processes independent of the mineral metabolism.
Bone formation is orchestrated by multiple stimuli and processes, and based on their embryological origin, the ossification of collagenous tissues is regulated by different paths. Compared to other musculoskeletal tissues, the bone has a high regenerative potential, with the skeleton being fully remodeled multiple times throughout the human lifespan. However, with a continuous extension of life expectancy, aging-related bone issues and pathologies have become more prominent, negatively impacting the quality of life of an increasing number of individuals.
While several mechanisms and pathways, such as the WNT, BMP2, or PTH signaling pathways, have been thoroughly studied over the last few decades, new scientific capabilities and perspectives allow for a more integrative and comprehensive view of bone development and regeneration. With the revolutionary rise of the omics field and the latest advances in cell lineage-tracing models and single-cell analysis, new molecular mechanisms are being elucidated, and important novel players are being recognized. For example, our understanding of epigenetic processes or metabolites that control bone integrity is growing at a rapid pace. In concert with the progress made recently in the development and design of new scaffolds and biomaterials, all these advances generate novel and alternative approaches to target bone regeneration and are under investigation, with the potential to increase the quality of life for many people.
This Special Issue of IJMS provides a platform for high-quality publications exploring novel insights on bone development and/or presenting new molecular and conceptual approaches for the manipulation of osteogenesis, bone regeneration, and bone homeostasis. This will provide a representative picture of the latest advances in bone research and serve as a road map for the future of the bone field.
Prof. Dr. Kazuo Yudoh
Guest Editor
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Keywords
- osteoblast
- osteocyte
- osteoclast
- mesenchymal stem cell
- cell differentiation
- epigenetics
- omics
- integrative analysis
- biomaterials
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