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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Emerging Role of Quantum Sciences and Radiation Biology in Biomedical Applications, 2nd Edition

edited by

Livio Giuliani

Pierre Madl

and

Nikolaj Sorgenfrei Blom

submission deadline 30 Dec 2025 | 2 articles | Viewed by 3106 | Submission Open

Keywords: quantum sciences; radiation biology; biomedical applications

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Insights into Mitochondrial Iron Metabolism: Connections to Cancer and Other Pathologies

edited by Michael Petronek

submission deadline 30 Dec 2025 | 1 articles | Viewed by 3025 | Submission Open

Keywords: iron metabolism; mitochondrial iron; cellular homeostasis; iron– sulfur cluster biogenesis; heme synthesis; mitochondrial ferritin; cancer biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innate Immunity: New Insights into Genetic and Signaling Networks

edited by

Styliani Sarrou

submission deadline 30 Dec 2025 | 2 articles | Viewed by 3004 | Submission Open

Keywords: innate immunity; innate immune response; signaling pathways; genetic variations

(This special issue belongs to the Section Molecular Immunology)

Advances in the Pathogenesis and Treatment of Heart Failure

edited by

Wioletta Szczurek-Wasilewicz

and

Bożena Szyguła-Jurkiewicz

submission deadline 30 Dec 2025 | 2 articles | Viewed by 2596 | Submission Open

Keywords: heart failure; biomarkers; pathways of heart failure; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innovative Strategies in Cancer Therapy

edited by

Paolo Coghi

and

Carmine Coluccini

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2578 | Submission Open

Keywords: tumor microenvironment; small molecules; IDO1 inhibition; checkpoint inhibitor therapy; adoptive T cell therapy; metabolic reprogram; resistance mechanisms; immune modulation; immune reconstitution; combination therapy; immunosuppression

(This special issue belongs to the Section Molecular Oncology)

Advances in Drug Delivery Systems: From Nanoparticles to Precision Medicine

edited by

Satya Prakash

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2573 | Submission Open

Keywords: polymer-based nanoparticles; lipid nanoparticles; PLGA and chitosan nano/microparticles for gene therapy; targeted drug delivery; nucleic acid-loaded nanoparticles; siRNA nanoparticles; nanoparticle-mediated mirna delivery; nanoparticles in cancer therapy; nanoparticles in vaccine design; nanoparticle-mediated gene therapy

(This special issue belongs to the Section Molecular Pharmacology)

Artificial Intelligence: Applications in the Field of Immune-Mediated Inflammatory Diseases and Onco-Hematology

edited by

Giuseppe Murdaca

and

Sebastiano Gangemi

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2508 | Submission Open

Keywords: artificial intelligence; machine learning; immune-mediated diseases; cancers; hematological ma-lignancies

(This special issue belongs to the Section Molecular Immunology)

Recent Advances in Hypertension and Cardiovascular Disease: 2nd Edition

edited by

Edyta Zbroch

submission deadline 30 Dec 2025 | 2 articles | Viewed by 2488 | Submission Open

Keywords: hypertension; hypertension pathophysiology; hypertension molecular mechanisms; cardiovascular disease; cardiovascular pathophysiology; cardiovascular molecular mechanisms; cardiovascular biomarkers; heart failure; coronary artery disease; chronic kidney disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanisms of Diabetic Cardiomyopathy

edited by Martin Michel

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2419 | Submission Open

Keywords: diabetes; cardiomyopathy; animal models; novel treatments; pathophyiology; SGLT2 inhibitors; neprilysin inhibitors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Cancer Stem Cell Research: 2nd Edition

edited by

Tomoyasu Sugiyama

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2298 | Submission Open

Keywords: cancer stem cell; biomarker; signaling; cancer-associated fibroblast; artificial intelligence; cell therapy; antibody therapy; cell therapy; gene expression

(This special issue belongs to the Section Molecular Oncology)

Plant Stress Biology

edited by Rui Li

submission deadline 30 Dec 2025 | 3 articles | Viewed by 2278 | Submission Open

Keywords: abiotic stress; biotic stress; stress response mechanisms; oxidative stress; phytohormones signaling; stress tolerance

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances in Anti-Cancer Drugs, 2nd Edition

edited by

Christiana Neophytou

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2079 | Submission Open

Keywords: combination therapy in cancer; small-molecule inhibitors in cancer; anti-cancer agents derived from natural sources; immunotherapy advances in cancer therapy; targeting metastatic dormancy; modulation of the tumor microenvironment; 3D model approaches in cancer research; predictive biomarkers for cancer chemoresistance

(This special issue belongs to the Section Molecular Oncology)

Advances in the Pathophysiology and Treatment of Eye Diseases

edited by

Georgios Panos

submission deadline 30 Dec 2025 | 2 articles | Viewed by 2042 | Submission Open

Keywords: ocular pathophysiology; eye diseases; molecular mechanisms; biomolecular pathways; therapeutic targets; translational ophthalmology; retinal degeneration; oxidative stress in ocular disorders; angiogenesis in eye diseases; neuroprotection in ophthalmology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

25th Anniversary of IJMS: Updates and Advances in Molecular Plant Sciences

edited by

Andrei Smertenko

submission deadline 30 Dec 2025 | 4 articles | Viewed by 1839 | Submission Open

Keywords: plant science; plant biochemistry; mechanisms; plant development; stress responses; plant physiology; genetics

(This special issue belongs to the Section Molecular Plant Sciences)

New Insights into Lectins

edited by Yuichiro Sato

submission deadline 30 Dec 2025 | 2 articles | Viewed by 1813 | Submission Open

Keywords: lectin; carbohydrate-binding specificity; virus; antiviral activity; cancer; anticancer activity; glycan-targeted therapy

(This special issue belongs to the Section Molecular Biology)

Dietary Antioxidants in Human Health

edited by

Marika Cordaro

Roberta Fusco

and

Rosanna Di Paola

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1806 | Submission Open

Keywords: diet; functional food; oxidative stress; mitochondrial disfunction; human health; animal models; nutrition; molecular pathways; human pathology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cutting-Edge Advances in Natural Bioactive Compounds

edited by

Luisa M. P. F. Amaral

and

Romeu A. Videira

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1783 | Submission Open

Keywords: natural bioactive compounds; discovery and isolation; chemical characterization; biological activities; mechanisms of action; pharmaceuticals; nutraceuticals; agricultural applications; cosmetic innovations

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Stroke: Novel Molecular Mechanisms and Therapeutic Approaches

edited by Kang-Ho Choi

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1680 | Submission Open

Keywords: stroke; cerebrovascular disease; mechanisms; treatment; diagnosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neutrophil Extracellular Traps (NETs) in Human Disease: Mechanisms, Pathophysiology and Therapeutic Potential

edited by

Rachel Shukrun

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1527 | Submission Open

Keywords: neutrophil extracellular traps (NETs) ; NETosis ; inflammation ; cancer microenvironment ; autoimmune disease ; thrombosis ; molecular signaling ; innate immunity ; biomarkers ; targeted therapy

(This special issue belongs to the Section Molecular Immunology)

Hematologic Malignancies: From Molecular Pathology to Novel Therapeutics

edited by

Myrna Gloria Candelaria

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1385 | Submission Open

Keywords: pathogenesis; B-cell lymphoma regulation; epigenetics and hematology; bispecific antibodies in hematology; hematologic malignancies

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances in Forensic Science: Integrating Innovation and Investigation

edited by

Aniello Maiese

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1347 | Submission Open

Keywords: DNA profiling; artificial intelligence; trace evidence analysis; immunohistochemical markers; molecular biology techniques; super-resolution microscopy; integrated forensic approach; new bioinformatics techniques; digital pathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Leptin Biology

edited by

Víctor Sánchez-Margalet

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1238 | Submission Open

Keywords: leptin; leptin expression; leptin receptor; leptin action

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Myocardial Injury and Ventricular Dysfunction: Pathways and Therapeutic Targets

edited by

Antonio Lax

submission deadline 30 Dec 2025 | 1 articles | Viewed by 960 | Submission Open

Keywords: myocardial injury; ventricular dysfunction; drug development; gene therapy; molecular modulators

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Circulating Cell-Free Nucleic Acids and Cancers: 3rd Edition

edited by

Bruna Scaggiante

submission deadline 30 Dec 2025 | 1 articles | Viewed by 927 | Submission Open

Keywords: biological fluids; cancer; cancer biomarkers; cfDI; cfDNA; cfNA; copy number variation; ctDNA; ddPCR; disease-free survival; epigenetic; epigenetic sequencing; exosome; extracellular vesicle; genotyping; liquid biopsy; miRNA; mRNA; mutation; ncRNA; next-generation sequencing; overall survival; progression-free survival; recurrence-free survival; whole-exome sequencing

(This special issue belongs to the Section Molecular Oncology)

Gene-Level Pharmacological Research on Natural Products

edited by

Wansu Park

submission deadline 30 Dec 2025 | Viewed by 909 | Submission Open

Keywords: natural products; gene-level pathways; pharmacological efficacy

(This special issue belongs to the Section Molecular Pharmacology)

New Challenges of Parkinson’s Disease, 2nd Edition

edited by

Franca Rosa Guerini

and

Cristina Agliardi

submission deadline 30 Dec 2025 | 1 articles | Viewed by 894 | Submission Open

Keywords: Parkinson’ s disease; neurodegeneration; synuclein; diagnosis; genetics; epigenetics; extracellular vesicles; biomarkers; treatments; rehabilitation

(This special issue belongs to the Section Molecular Neurobiology)

Novel Multifunctional Materials with Electrical, Catalytic, and Biological Properties

edited by

Jana Pisk

and

Luka Pavic

submission deadline 30 Dec 2025 | Viewed by 837 | Submission Open

Keywords: novel multifunctional materials; innovative design and synthesis; electrical properties; catalytic properties; biological properties

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms of Cell Adhesion

edited by

Surajit Bhattacharjya

submission deadline 30 Dec 2025 | Viewed by 778 | Submission Open

Keywords: cell adhesion; cell– cell communication; structures; drug discovery; integrins; cadherins; selectins

(This special issue belongs to the Section Molecular Biophysics)

Molecular and Cellular Mechanisms in Learning and Memory

edited by

Giovanna Traina

submission deadline 30 Dec 2025 | Viewed by 646 | Submission Open

Keywords: learning; memory; animal models; conditioning; molecular mechanisms; genetic mechanisms; epigenetic mechanisms

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Cellular Mechanisms of Genotoxicity

edited by

Bernd Kaina

submission deadline 30 Dec 2025 | Viewed by 626 | Submission Open

Keywords: DNA damage; gene instab; genetic instab; DNA methyl; genotoxic; gene mutation; DNA repair; genotoxicity; toxicogenetic; toxicogenomic

(This special issue belongs to the Section Molecular Toxicology)

Stem Cell Innovations and Reproductive Biotechnologies

edited by

Marcin Samiec

submission deadline 30 Dec 2025 | Viewed by 598 | Submission Open

Keywords: mammals; birds; stem cell research; pluri-/multipotency; differentiation/dedifferentiation; assisted reproductive technologies (ARTs); transgenic research; biomedicine

(This special issue belongs to the Section Molecular Biology)

Diabetic Retinopathy—Innovation in Diagnosis and Treatment

edited by

Peter Koulen

submission deadline 30 Dec 2025 | Viewed by 596 | Submission Open

Keywords: diabetes mellitus; diabetic macular edema; diagnostics; drug development; neovascularization; neurodegeneration; neuroprotection; retina; therapeutics; vascular disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancements in Genomic Technologies for Molecular Safety Assessment

edited by

Eric Blomme

submission deadline 30 Dec 2025 | Viewed by 572 | Submission Open

Keywords: gene expression; safety assessment; genomic technologies; genomic tools; molecular toxicology; toxicity; predictive safety assessments; proteomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research on Pathophysiology of Multiple Sclerosis and Neuroinflammation

edited by

Fabrizio Michetti

submission deadline 30 Dec 2025 | Viewed by 497 | Submission Open

Keywords: multiple sclerosis (MS); autoimmune diseases; encephalomyelitis; neuroinflammation; central nervous system (CNS); autoimmunity and neurodegeneration; molecular basis of immune mechanisms

(This special issue belongs to the Section Molecular Neurobiology)

Metal-Based Compounds: Molecular Mechanisms of Pharmacological Action and Toxicity

edited by

Danijela Z. Krstić

submission deadline 30 Dec 2025 | Viewed by 492 | Submission Open

Keywords: metal elements and ions; metal complexes; metal nanoclusters; pharmacology andpharmacokinetics; in vitro toxicity; in vivo toxicity; toxicity biomarkers; enzymes as pharmacological and toxicity targets; toxicity mechanisms; metallodrugs

(This special issue belongs to the Section Molecular Toxicology)

Brain Ischemia: From Molecular Mechanisms to Innovative Therapies

edited by

Ryszard Pluta

submission deadline 30 Dec 2025 | Viewed by 369 | Submission Open

Keywords: ischemic neurodegeneration; focal brain ischemia; global brain ischemia; perinatal asphyxia; ischemic stroke; traumatic brain injury; apnea; neuroinflammation; proteins; genes; genes involved in neurodegeneration; glia-to-neurons genetic conversion; dementia; Alzheimer’s disease; genetic conversion of ischemia to Alzheimer's disease; new therapeutic approaches; biomarkers

(This special issue belongs to the Section Molecular Biology)

Molecular Insight into Antimicrobial Resistance

edited by

Dan-Alexandru Țoc

and

Carmen Costache

submission deadline 30 Dec 2025 | Viewed by 362 | Submission Open

Keywords: antimicrobial resistance; MRSA; ESBL-producing bacteria; carbapenem-resistant enterobacterales (CRE); vancomycin-resistant enterococci (VRE); linezolid resistance; novel antibiotic combinations; resistance mechanisms; horizontal gene transfer; molecular epidemiology

(This special issue belongs to the Section Molecular Pharmacology)

Electromagnetic Field Interactions with Biomolecules

edited by Samina Masood

submission deadline 30 Dec 2025 | Viewed by 361 | Submission Open

Keywords: magnetic field; biomolecules; medicine; drug delivery; protective methods; disease control

(This special issue belongs to the Section Biochemistry)

Advances in Regenerative Medicine, Organ Bioengineering and Transplantation

edited by

Dorota Latek

submission deadline 30 Dec 2025 | Viewed by 361 | Submission Open

Keywords: regenerative medicine; organ bioengineering; transplantation; allografting; stem cells; drug discovery; immunosuppression; xenotransplantation; organogenesis; biomaterials

(This special issue belongs to the Section Molecular Immunology)

Neuroimmune Regulation of Acute and Chronic Pain

edited by Karen M. Wagner

submission deadline 30 Dec 2025 | Viewed by 323 | Submission Open

Keywords: acute pain; chronic pain; central sensitization; neuroinflammation; neuroimmunity; neurovascular coupling; cytokines; chemokines; catacholamines; stress

(This special issue belongs to the Section Molecular Neurobiology)

Skin Cancer: A Focus from Pathophysiology to Novel Therapeutic Strategies

edited by

Piotr Sobolewski

submission deadline 30 Dec 2025 | Viewed by 261 | Submission Open

Keywords: skin cancer; melanoma; keratinocyte carcinoma; pathophysiology; biomarkers; immunotherapy; targeted therapy; nanomedicine; resistance; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Role of Mitochondria in Neurodegenerative Diseases

edited by Małgorzata Wojtkowska

submission deadline 30 Dec 2025 | Viewed by 250 | Submission Open

Keywords: mitochondria; ccfDNA; Parkinson’ s disease’ Alzheimer’ s disease

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Obesity Research: Metabolic Pathways and Pathophysiological Factors

edited by Aleksandra Stefanović

submission deadline 30 Dec 2025 | Viewed by 244 | Submission Open

Keywords: obesity; inflammation; oxidative stress; obesity-related diseases; adypocitokines

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Basis for Sustainable Management of Migratory Insects

edited by

Xingfu Jiang

submission deadline 30 Dec 2025 | Viewed by 230 | Submission Open

Keywords: migrant insects; molecular basis of population growth; migration and reproduction; migration and immunity; migration and diapause; migration and orientation; molecular regulation of migration

(This special issue belongs to the Section Molecular Biology)

Innovative Immune-Modulating Therapies and Cutting-Edge Technologies for Immune-Related Diseases

edited by

Xingxing Fan

submission deadline 30 Dec 2025 | Viewed by 207 | Submission Open

Keywords: immune heomostasis; immune related diseases; small molecules; cell therapy; bacteria and virus; antibodies

(This special issue belongs to the Section Molecular Immunology)

Role of Immune and Inflammatory Cells in Pulmonary Diseases

edited by Remo C. Russo

submission deadline 30 Dec 2025 | Viewed by 204 | Submission Open

Keywords: idiopathic pulmonary fibrosis (IPF); pulmonary immunology; precision medicine; single-cell RNA sequencing (scRNA-seq); spatial transcriptomics sequencing; animal model of pulmonary fibrosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Synthesis, Characterization and Applications of Advanced Polymer Materials

edited by Namil Kim

submission deadline 30 Dec 2025 | Viewed by 191 | Submission Open

Keywords: synthesis methodologies; molecular architecture; functional polymers; characterization techniques; cutting-edge applications

(This special issue belongs to the Section Macromolecules)

Machine Learning in Disease Diagnosis and Treatment: 2nd Edition

edited by

Makrina Karaglani

submission deadline 30 Dec 2025 | Viewed by 180 | Submission Open

Keywords: machine learning; diagnosis; treatment; algorithm; predictive; artificial intelligence

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Immunotherapy in Cancer

edited by Magdalena Król

submission deadline 30 Dec 2025 | Viewed by 173 | Submission Open

Keywords: cancer immunotherapy; tumor microenvironment; immune checkpoint inhibitors; monoclonal antibodies; cytokine signaling; tumor immune evasion; metabolic regulation in cancer; cell-based therapies

(This special issue belongs to the Section Molecular Immunology)

Epigenetic Regulation in Cell Development, Differentiation and Cell Fate

edited by Gang Ren

submission deadline 30 Dec 2025 | Viewed by 161 | Submission Open

Keywords: 3D genome; myogenesis; transgenerational inheritance; enhancer– promoter interaction; histone modification; epigenetic variation; complex traits

(This special issue belongs to the Section Molecular Genetics and Genomics)

Displaying special issue 551-600 on page 12 of 65.

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