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Advances in Drug Delivery Systems: From Nanoparticles to Precision Medicine

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: closed (30 December 2025) | Viewed by 6275

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Guest Editor
Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering, Faculty of Medicine and Health Sciences, McGill University, Montréal, QC H3A 2B4, Canada
Interests: drug delivery; gene therapy; biomedicine; nanoparticles; nanomedicine; nanotechnology; the microbiome; probiotics; chronic diseases; Alzheimer’s; cancer; aging; targeted delivery
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Special Issue Information

Dear Colleagues,

Nanoparticles hold considerable promise for advancing the delivery of pharmacologically active therapeutics targeting a variety of diseases. Although numerous nanoparticle formulations are still in early development or pre-clinical testing, some have proven clinically significant by enhancing drug delivery, targeting, and efficacy while reducing drug toxicity. Their suitability as drug delivery systems is attributed to their small particle size, high surface area, potential for surface modification, active targeting, stimuli-responsive delivery, and prolonged circulation times.

This Special Issue will explore the latest progress in nanoparticle design, characterization, drug delivery, and toxicity. You are invited to contribute to this Special Issue of the International Journal of Molecular Sciences, entitled “Advances in Drug Delivery Systems: From Nanoparticles to Precision Medicine”. This Special Issue will focus on the utility of nanoparticles in drug delivery and the necessary features for their clinical translation.

Prof. Dr. Satya Prakash
Guest Editor

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Keywords

  • polymer-based nanoparticles
  • lipid nanoparticles
  • PLGA and chitosan nano/microparticles for gene therapy
  • targeted drug delivery
  • nucleic acid-loaded nanoparticles
  • siRNA nanoparticles
  • nanoparticle-mediated mirna delivery
  • nanoparticles in cancer therapy
  • nanoparticles in vaccine design
  • nanoparticle-mediated gene therapy

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Published Papers (2 papers)

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Review

21 pages, 2282 KB  
Review
Terpenoid Phytosomes as Advanced Delivery Systems: Molecular Interactions, Pharmacological Potential, and Scalable Manufacturing Approaches
by Shynggys Sergazy, Shyngys Aliakpar, Gulimzhan Adekenova, Khorlan Itzhanova, Orazio Taglialatela-Scafati and Sergazy Adekenov
Int. J. Mol. Sci. 2026, 27(6), 2868; https://doi.org/10.3390/ijms27062868 - 22 Mar 2026
Cited by 2 | Viewed by 789
Abstract
Terpenoids represent a large class of bioactive natural compounds with promising pharmacological properties, including anti-inflammatory, antimicrobial, and anticancer activities. However, their clinical application is often limited by poor aqueous solubility, low membrane permeability, and suboptimal bioavailability. Phytosomal delivery systems have emerged as a [...] Read more.
Terpenoids represent a large class of bioactive natural compounds with promising pharmacological properties, including anti-inflammatory, antimicrobial, and anticancer activities. However, their clinical application is often limited by poor aqueous solubility, low membrane permeability, and suboptimal bioavailability. Phytosomal delivery systems have emerged as a promising strategy to enhance the pharmacokinetic performance of plant-derived compounds by forming molecular complexes between bioactive molecules and phospholipids. This review critically examines the structural principles, preparation methods, physicochemical characterization, and biological performance of terpenoid phytosomes. Particular attention is given to the molecular interactions between terpenoids and phospholipids that govern complex formation and vesicular assembly. The review also summarizes current analytical techniques used to confirm phytosome formation and discusses the influence of formulation parameters, including phospholipid composition and molar ratios, on stability and biological activity. In addition, emerging insights from molecular modeling and membrane interaction studies are considered to better understand the mechanisms underlying improved drug delivery. Finally, challenges related to safety assessment, manufacturing scalability, and clinical translation of phytosomal systems are discussed. Overall, terpenoid phytosomes represent a promising nanodelivery platform capable of improving the pharmacokinetic profile and therapeutic potential of terpenoid compounds. Full article
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27 pages, 1603 KB  
Review
Cell-Based Drug Delivery Systems: Innovative Drug Transporters for Targeted Therapy
by Shynggys Sergazy, Kulzhan Berikkhanova, Alexandr Gulyayev, Zarina Shulgau, Assiya Maikenova, Ruslan Bilal, Milan Terzic, Zhaxybay Zhumadilov and Mohamad Aljofan
Int. J. Mol. Sci. 2025, 26(17), 8143; https://doi.org/10.3390/ijms26178143 - 22 Aug 2025
Cited by 8 | Viewed by 4790
Abstract
Significant progress has been made in developing cell-based drug delivery systems that utilize the intrinsic biological properties of various cell types—erythrocytes, leukocytes, platelets, stem cells, and even spermatozoa—to improve drug targeting, bioavailability, and biocompatibility. This review presents an integrative analysis of the latest [...] Read more.
Significant progress has been made in developing cell-based drug delivery systems that utilize the intrinsic biological properties of various cell types—erythrocytes, leukocytes, platelets, stem cells, and even spermatozoa—to improve drug targeting, bioavailability, and biocompatibility. This review presents an integrative analysis of the latest advances in cell-based drug delivery systems, focusing on their design, pharmacokinetics, cellular interactions, and therapeutic potential. We specifically focus on hybrid microrobots and membrane-coated nanocarriers as emerging biohybrid platforms. Despite these advances, translation to the clinical phase remains constrained by persistent limitations, such as immune clearance, loss of membrane integrity during cargo loading, limited tissue penetration of carrier cells, and manufacturing challenges. Finally, we highlight future directions, including CAR-cell combinations and artificial cell engineering, that promise to expand the clinical utility of cell-based drug delivery systems in oncology, infectious diseases, and regenerative medicine. Full article
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