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Recent Advances in Anti-Cancer Drugs, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 55

Special Issue Editor


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Guest Editor
Apoptosis and Cancer Chemoresistance Laboratory, Basic and Translational Cancer Research Center, Department of Life Sciences, European University Cyprus, Nicosia 2404, Cyprus
Interests: targeted cancer therapy; apoptosis; metastasis; cancer chemoresistance; pancreatic cancer; breast cancer; lung cancer
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Special Issue Information

Dear Colleagues,

It is a pleasure for me to invite you to contribute to this Special Issue in IJMS that aims to collect the latest information on a wide variety of novel anti-cancer therapies. Despite all the advances of the last decades, many challenges remain in targeting aggressive and resistant cancer. The design of new drugs or improvement of current therapies remains at the forefront of cancer research. In addition, identifying the underlying causes of cancer chemoresistance as well as the discovery of biomarkers that predict patient response to treatment are pivotal for enhancing therapeutic efficacy.

In this Special Issue, we aim to report the latest developments on anti-cancer therapy, with special emphasis on targeting difficult-to-treat cancers, including but not limited to triple negative breast cancer, lung, pancreatic cancer and glioblastoma. Efforts to evaluate the efficacy of anti-cancer drugs and reverse chemoresistance in the pre-clinical setting will also be included. Potential contributors are invited to submit papers on the following topics:

  • Synergistic anti-cancer therapy, especially involving small-molecule inhibitors and agents derived from natural sources;
  • Therapeutic approaches to reverse cancer chemoresistance as well as identification of underlying mechanisms of resistance;
  • Recent developments in immunotherapy;
  • Predictive biomarkers, especially derived from liquid biopsies, to determine therapeutic efficacy;
  • Anti-cancer drugs targeting metastatic dormancy;
  • Agents that modulate the tumor microenvironment for improving therapeutic efficacy;
  • Modern approaches in preclinical drug discovery including 3D culture systems.

Experimental studies using in vitro and in vivo models and review articles are all welcome for consideration.

Dr. Christiana Neophytou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • combination therapy in cancer
  • small-molecule inhibitors in cancer
  • anti-cancer agents derived from natural sources
  • immunotherapy advances in cancer therapy
  • targeting metastatic dormancy
  • modulation of the tumor microenvironment
  • 3D model approaches in cancer research
  • predictive biomarkers for cancer chemoresistance

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Published Papers (1 paper)

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Research

25 pages, 2743 KiB  
Article
Active Substances from the Micro-Immunotherapy Medicine 2LC1® Show In Vitro Anti-Cancer Properties in Colon, Prostate, and Breast Cancer Models and Immune-Enhancing Capabilities in Human Macrophages
by Camille Jacques, Irene Marchesi, Francesco Paolo Fiorentino, Flora Marchand, Mathias Chatelais and Ilaria Floris
Int. J. Mol. Sci. 2025, 26(9), 4300; https://doi.org/10.3390/ijms26094300 - 1 May 2025
Abstract
Tumor-associated macrophages (TAMs) play a pivotal role in cancer regulation by influencing tumor growth, metastasis, and the immune microenvironment. By providing low doses and ultra-low doses (ULD) of immune regulators to the organism, micro-immunotherapy (MI) medicines (MIM) could be seen as valuable adjuvant [...] Read more.
Tumor-associated macrophages (TAMs) play a pivotal role in cancer regulation by influencing tumor growth, metastasis, and the immune microenvironment. By providing low doses and ultra-low doses (ULD) of immune regulators to the organism, micro-immunotherapy (MI) medicines (MIM) could be seen as valuable adjuvant drugs in the context of a wide range of pathological conditions, including cancers. Thus, these MIM could target TAMs, affecting their phenotype and activities. In this study, the anti-tumor and the immune-stimulatory effects of four capsules out of the ten composing the Labo’life’s MIM 2LC1® (2LC1-1, 2LC1-6, 2LC1-7, and 2LC1-8), as well as the specific nucleic acid (SNA®) sequence SNA-MYC present at ULD in this medicine have been evaluated in vitro, in several cancer models, and in human monocyte-derived macrophages. Our results showed that the tested MI formulations increased the tumor cell death of spheroids from HCT-116 colon cancer cells, while reducing the spheroid volume. Moreover, the treatments impaired the clonogenic capabilities of two cancer cell lines from epithelial origin, the LNCaP prostate cancer and the MCF-7 breast cancer cells. Interestingly, ULD of the SNA-MYC shared similar anti-cancer capabilities in those models, and it led to a significant reduction in the expression of C-MYC when evaluated in a model of human M2 macrophages. In the same model, the MI formulations also increased the expression of CD86 and HLA-DR, two markers of M1 anti-tumor macrophages. In addition, the tested items modulated the secretion of a panel of chemokines related to macrophage activity and immune cell recruitment. Finally, our results showed that 2LC1-8 increased the phagocytosis capabilities of human monocyte-derived macrophages, thus possibly contributing to sustaining the immune functions of M1, which are crucial in the context of cancer. Even if more research is needed to uncover their exact mechanism of action, these results suggest that the tested capsules of 2LC1 as well as ULD of SNA-MYC display both anti-tumor and immune-enhancing effects. Full article
(This article belongs to the Special Issue Recent Advances in Anti-Cancer Drugs, 2nd Edition)
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