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Recent Advances in Hypertension and Cardiovascular Disease: 2nd Edition

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Guest Editor
Department of Internal Medicine and Hypertension, Faculty of Medicine, Medical University of Bialystok, 15-089 Bialystok, Poland
Interests: primary and secondary hypertension especially due to renal artery stenosis or kidney disorders; chronic kidney disease; cardiovascular disease; cardiovascular risk factors
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Special Issue Information

Dear Colleagues,

This Special Issue is the continuation of our previous Special Issue “Recent Advances in Hypertension and Cardiovascular Disease”, published in 2022–2024.

Hypertension (HT) remains the most important risk factor for premature cardiovascular disease (CVD), including stroke, coronary artery disease, heart failure, atrial fibrillation, and peripheral vascular disease, as well as for chronic kidney disease (CKD). On the other hand, CKD is an independent risk factor for the development of—often, more severe—coronary artery disease, and CKD is also associated with adverse outcomes in those with existing cardiovascular disease. HT is a very common symptom in patients with CKD. It affects approximately 80 to 85 percent of this population. CVD consistently remains the leading cause of death worldwide; therefore, it is extremally important to know the pathophysiology, molecular mechanisms, and biomarkers of cardiovascular disorders as well as other diseases leading to the development of CVD.

This Special Issues focuses on the pathophysiology, molecular mechanisms, and biomarkers of hypertension and CVD, with particular emphasis on chronic kidney disease, providing better knowledge regarding their development and consequently contributing to more effective prevention, the earliest diagnosis, and thus, appropriate treatment.

We warmly welcome submissions, including original papers and reviews, regarding this widely discussed topic. Data related to molecular mechanisms or pathophysiology are essential, and papers that only contain clinical trials/data are not acceptable.

Prof. Dr. Edyta Zbroch
Guest Editor

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Keywords

  • hypertension
  • hypertension pathophysiology
  • hypertension molecular mechanisms
  • cardiovascular disease
  • cardiovascular pathophysiology
  • cardiovascular molecular mechanisms
  • cardiovascular biomarkers
  • heart failure
  • coronary artery disease
  • chronic kidney disease

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Published Papers (1 paper)

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Research

14 pages, 1008 KiB  
Article
Metabolomics, Genetics, and Environmental Factors: Intersecting Paths in Abdominal Aortic Aneurysm
by Lilian Fernandes Silva, Jagadish Vangipurapu, Anniina Oravilahti, Aldons Jake Lusis and Markku Laakso
Int. J. Mol. Sci. 2025, 26(4), 1498; https://doi.org/10.3390/ijms26041498 - 11 Feb 2025
Viewed by 639
Abstract
Abdominal aortic aneurysm represents a significant public health concern, particularly in men aged 55 to 64, where it occurs in about 1%. We investigated the metabolomics and genetics of AAA by analyzing a cohort including 76 patients with AAA and randomly selected 228 [...] Read more.
Abdominal aortic aneurysm represents a significant public health concern, particularly in men aged 55 to 64, where it occurs in about 1%. We investigated the metabolomics and genetics of AAA by analyzing a cohort including 76 patients with AAA and randomly selected 228 controls. Utilizing the Metabolon DiscoveryHD4 platform for non-targeted metabolomics profiling, we identified several novel metabolites significantly associated with AAA. These metabolites were primarily related to environmental and lifestyle factors, notably smoking and pesticide exposure, which underscores the influence of external factors on the progression of AAA. Additionally, several genetic variants were associated with xenobiotics, highlighting a genetic predisposition that may exacerbate the effects of these environmental exposures. The integration of metabolomic and genetic data provides compelling evidence that lifestyle, environmental, and genetic factors are intricately linked to the etiology of AAA. The results of our study not only deepen the understanding of the complex pathophysiology of AAA but also pave the way for the development of targeted therapeutic strategies. Full article
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