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Role of Mitochondria in Neurodegenerative Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 30 December 2025 | Viewed by 656

Special Issue Editor


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Guest Editor
Department of Bioenergetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, 61-614 Poznan, Poland
Interests: mitochondria; function and evolution; mitochondria and ccfDNA; Parkinson diseases
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Special Issue Information

Dear Colleagues,

For the last decade, mitochondria have been studied intensively in their role in the pathogenesis of many neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. There is a growing body of evidence on the influence of mitochondrial dysfunction regarding protein import, mitochondrial dynamics, and redox imbalance causing neurodegenerative diseases.

This Special Issue summarizes and discusses different aspects of mitochondrial metabolism and functions, opening new avenues in understanding mitochondrial biology. The goal of the proposed Special Issue, “Role of Mitochondria in Neurodegenerative Diseases”, is to understand all the available mechanisms of intervention into mitochondrial functioning and its communication with the nucleus so as to prevent or repair unwanted changes in mitochondrial structure and function. In this Special Issue, original research articles and reviews are welcome. We look forward to receiving your contributions.

Dr. Małgorzata Wojtkowska
Guest Editor

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Keywords

  • mitochondria
  • ccfDNA
  • Parkinson’s disease’ Alzheimer’s disease

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Published Papers (1 paper)

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Review

23 pages, 1973 KB  
Review
Cell-Free DNA and Mitochondria in Parkinson’s Disease
by Małgorzata Wojtkowska and Franciszek Ambrosius
Int. J. Mol. Sci. 2025, 26(23), 11615; https://doi.org/10.3390/ijms262311615 - 30 Nov 2025
Viewed by 378
Abstract
Parkinson’s disease (PD) is a progressive neurodegenerative disorder marked by the gradual and irreversible loss of neurons, especially within the substantia nigra region of the midbrain. Early and accurate diagnosis remains a significant challenge in both research and clinical practice. This difficulty is [...] Read more.
Parkinson’s disease (PD) is a progressive neurodegenerative disorder marked by the gradual and irreversible loss of neurons, especially within the substantia nigra region of the midbrain. Early and accurate diagnosis remains a significant challenge in both research and clinical practice. This difficulty is further compounded by the substantial clinical and molecular heterogeneity of PD, emphasizing the urgent need for reliable biomarkers to enhance diagnostic precision and guide therapeutic strategies. One promising candidate biomarker is cell-free DNA (cfDNA), comprising short DNA fragments composed of mitochondrial (cf-mtDNA) and nucleus-derived (cf-ntDNA) DNA. cfDNA is released into body fluids through physiological or pathological processes such as apoptosis, necrosis, NETosis, or active secretion. The presence of cfDNA in human biological fluids has been utilized for years in oncology and prenatal medicine and, more recently, it has gained attention as a non-invasive diagnostic tool in the context of neurodegenerative diseases such as PD. This review article aims to provide a comprehensive overview of the current knowledge on the origin of cfDNA, highlighting the roles of the mitochondria and cf-mtDNA in PD, mitochondria quality control, and neuroinflammation in cfDNA biogenesis. The review collates available research on cfDNA types in human serum, plasma, and CSF, sequence analysis, and its potential application as a biomarker in the diagnosis and monitoring of PD, contributing to the ongoing search for non-invasive biomarkers of neurodegenerative diseases. Full article
(This article belongs to the Special Issue Role of Mitochondria in Neurodegenerative Diseases)
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