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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Latest Advances in Aquatic Genetic Improvement

edited by Jun Qiang,

Yifan Tao

and Wenjing Tao

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2478 | Submission Open

Keywords: aquaculture genetic breeding; genomic selection; gene editing; disease-resistant breeding; multi-omics analysis; stress resistance enhancement; smart aquaculture; artificial intelligence

(This special issue belongs to the Section Molecular Genetics and Genomics)

Melanoma: Molecular Diagnosis and Treatment

edited by

Teresa Lettini

submission deadline 20 Sep 2026 | 1 articles | Viewed by 2407 | Submission Open

Keywords: molecular pathology; melanoma; skin cancer; molecular pathway; dermatopathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Interactions and Advanced Computational Methods for Biomolecular Systems

edited by

Amar Singh

submission deadline 20 Sep 2026 | 1 articles | Viewed by 2403 | Submission Open

Keywords: molecular interactions; biological systems; computational biology; protein–protein interactions; protein docking; bioinformatics; structural modeling; multiscale modeling techniques

(This special issue belongs to the Section Molecular Biophysics)

Molecular Pharmacology of Protein Kinase Inhibitor

edited by

Liming Hu

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2368 | Submission Open

Keywords: protein kinase inhibitor; molecular pharmacology; signaling pathway; preclinical/clinical evaluation; computational modeling; toxicity

(This special issue belongs to the Section Molecular Pharmacology)

Advanced Functionalization of Biopolymers and Bio-Oligomers for Precision Therapeutics

edited by

Dayong Wang

submission deadline 20 Sep 2026 | 1 articles | Viewed by 2242 | Submission Open

Keywords: precision therapeutics; biopolymers; drug delivery; biopharmaceuticals; pharmacology

(This special issue belongs to the Section Materials Science)

Updates on Metal Ions and Related Complexes in Molecular Biology and Biochemistry

edited by

Makan Golizeh

submission deadline 20 Sep 2026 | 1 articles | Viewed by 2224 | Submission Open

Keywords: biochemistry; homeostasis; metal ions; metal ion complexes; metallomics; molecular biology; molecular pathogenesis; quantification; systems biology; toxicity

(This special issue belongs to the Section Biochemistry)

Innovative Biomaterials for Advanced Applications in Regenerative Medicine and Drug Delivery

edited by

Calogero Fiorica

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2177 | Submission Open

Keywords: biomaterials; drug delivery; regenerative medicine; stimuli-responsive polymers; 3D scaffolds; micro-nanocarriers

(This special issue belongs to the Section Materials Science)

Schiff Bases and Their Metal Complexes: Structure, Synthesis, and Biological Application

edited by Nenad Filipovic

submission deadline 20 Sep 2026 | 1 articles | Viewed by 2158 | Submission Open

Keywords: hydrazones; (thio/seleno)semicarbazones; oximes; antimicrobial activity; anticancer activity; enzyme inhibition; metal complexes; diagnostic agents; photothermal therapy; photodynamic therapy

(This special issue belongs to the Section Biochemistry)

From Plant Genomics Investigations to Plant Biotechnology Exploitation

edited by

Maria R. Ercolano

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2126 | Submission Open

Keywords: sequencing; plant genomes; biotechnological applications; translational genomics; new discoveries

(This special issue belongs to the Section Molecular Plant Sciences)

Beyond Drivers and Suppressors: Investigating Upstream Regulators of Cell Death

edited by

Damian Kołat

submission deadline 20 Sep 2026 | 1 articles | Viewed by 2122 | Submission Open

Keywords: cell death; driver genes; suppressor genes; upstream regulators; gene expression; in silico; in vitro; in vivo

(This special issue belongs to the Section Molecular Biology)

Molecular Aspects of Retinal Neurodegeneration and Neuroprotection

edited by

Kyriaki Thermos

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2114 | Submission Open

Keywords: retinal neurodegeneration; neuroprotection; therapeutic targets; retinal ischemia; excitotoxicity; oxidative stress; mitochondrial dysfunction; neuroinflammation; vascular dysfunction

(This special issue belongs to the Section Molecular Neurobiology)

Advanced Oxidation Processes and Biodegradation for Emerging Contaminants Treatment: 2nd Edition

edited by

Chengdu Qi

submission deadline 20 Sep 2026 | 1 articles | Viewed by 2082 | Submission Open

Keywords: advanced oxidation processes; persistent organic compounds; water pollution control; biodegradation; emerging contaminants; water treatment; wastewater treatment; toxicity assessment

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Recent Advances in Herpesviruses (2nd Edition)

edited by

Marisa Granato

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2058 | Submission Open

Keywords: α-herpesviridae; β-herpesviridae; γ-herpesviridae; herpesviruses associated diseases

(This special issue belongs to the Section Molecular Microbiology)

Brain–Immune Crosstalk and Ischemic Injury

edited by

Yvonne Couch

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2053 | Submission Open

Keywords: stroke; ischemia; haemorrhage; inflammation; cytokines; macrophages; neutrophils; microglia; immunity

(This special issue belongs to the Section Molecular Immunology)

Adipose Tissue and Adipose Tissue-Derived Stem Cells in Multidisciplinary Research

edited by Oliver Felthaus

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2047 | Submission Open

Keywords: adipose tissue; adipose-derived stem cells; regenerative medicine; tissue engineering

(This special issue belongs to the Section Molecular Biology)

New Trends in Alzheimer’s Disease Research: From Molecular Mechanisms to Therapeutics: 3rd Edition

edited by

Ramón Cacabelos

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2035 | Submission Open

Keywords: Alzheimer’s disease; pathogenic mechanisms; genomics; epigenetics; biomarkers; prevention; treatment; pharmacogenetics

(This special issue belongs to the Section Molecular Neurobiology)

Using Model Organisms to Study Complex Human Diseases—2nd Edition

edited by

Roberto Piergentili

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1939 | Submission Open

Keywords: model organism; Escherichia coli; yeast; Caenorhabditis elegans; Drosophila melanogaster; zebrafish; Arabidopsis thaliana; Xenopus laevis; rat and mouse model; human disease; inherited disease; cancer; rare disease; genetics

(This special issue belongs to the Section Molecular Biology)

Mechanisms in Biofilm Formation, Tolerance and Control: 3rd Edition

edited by

Manuel Simões

and Lúcia Chaves Simões

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1912 | Submission Open

Keywords: adhesion; antimicrobial action; antimicrobial resistance; biofilm development; biofilm matrix; biofilm structure; quorum sensing; motility; surfaces

(This special issue belongs to the Section Molecular Microbiology)

Health Impacts of Environmental Pollution on the Urogenital and Reproductive Systems

edited by

Anna Perri

and

Silvestro Antonio Ruffolo

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1896 | Submission Open

Keywords: pollution; endocrine toxicity; endocrine disruptors; human biomonitoring; infertility; cancer; inflammation; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Prostate Cancer, 2nd Edition

edited by

Yaser Gamallat

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1896 | Submission Open

Keywords: prostate cancer; molecular biology; genomics; biomarkers; signaling pathways; precision medicine; treatment resistance; epigenetics; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondrial Dysfunction in Disease: Mechanisms, Biomarkers and Emerging Therapies

edited by

Alexandre Umpierrez Amaral

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1847 | Submission Open

Keywords: mitochondria; bioenergetic homeostasis; calcium homeostasis; redox homeostasis; oxidative stress; biogenesis; mitophagy; dynamics

(This special issue belongs to the Section Biochemistry)

Genetic and Molecular Research on the Malaria Parasite

edited by Hajime Hisaeda and

Takashi Imai

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1834 | Submission Open

Keywords: plasmodium; malaria parasite; molecular biology; genomics; gene expression; host–parasite interaction; drug resistance; vaccine development

(This special issue belongs to the Section Molecular Microbiology)

Heterogeneous Catalysis Towards a Sustainable Future: Energy Conversion and Green Synthesis

edited by Chen Wu and

Shaodong Zhou

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1830 | Submission Open

Keywords: heterogeneous catalysis; CO2 hydrogenation; CO2 electroreduction; water splitting; Fischer-Tropsch synthesis; oxidative coupling of methane; methane dry reforming; green synthesis; fine chemicals; sustainable energy; catalyst design; active site engineering; single-atom catalysts; metal–organic frameworks; zeolites; nanostructured catalysts; in situ and operando characterizations; photocatalysis; electrocatalysis; biomass valorization; reaction engineering; renewable feedstocks

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Drug Discovery and Development for Renal Disease Treatment

edited by

Keiko Hosohata

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1809 | Submission Open

Keywords: kidney disease; medicinal chemistry; drug discovery; computer-assisted drug design; drug targets; in vitro assays; epigenetic targets; multi-targeting compounds; biophysical methods; target engagement studies

(This special issue belongs to the Section Molecular Pharmacology)

Beyond the Resolution Revolution: The Next Era of Cryo-EM and Structural Biology

edited by

Gaya P. Yadav

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1804 | Submission Open

Keywords: cryo-electron microscopy (cryo-EM); membrane protein structure; cryo-tomography and 3D reconstruction; advances in sample vitrification; structure-guided drug discovery; lipid–protein dynamics; innovations in cryo-EM methodology

(This special issue belongs to the Section Molecular Biology)

Vitamin K in Disease Mechanisms and Therapy

edited by Maria Kokozidou

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1797 | Submission Open

Keywords: vitamins K; vitamins K-soluble proteins; vitamin K-dependent clotting factors; matrix Gla protein; calcification of blood vessels; vascular stiffness; cardiac output; stroke volume

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Understanding the Molecular Basis of Antimicrobial Properties in Natural Products, Functional Additives, and Food-Derived Compounds

edited by

Aleksandra Maria Kocot

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1740 | Submission Open

Keywords: natural antibacterial substances; antibacterial activity; bacterial metabolites; functional additives; antibacterial peptides

(This special issue belongs to the Section Biochemistry)

Advances in Molecular Biology of Ovarian Cancer

edited by

Stefania Scicchitano

and Cinzia Garofalo

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1737 | Submission Open

Keywords: ovarian cancer; signaling pathways; transcription factors; cancer metabolism; chemoresistance; tumor microenvironment; ovarian cancer stem cells; cancer therapies

(This special issue belongs to the Section Molecular Oncology)

Current Research for Ovarian Cancer Biology and Therapeutics (Second Edition)

edited by

Carmela Ricciardelli

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1717 | Submission Open

Keywords: ovarian cancer; chemotherapy resistance; metastasis; novel therapeutic agents; immunotherapy; CAR-T cells; cancer chemotherapy; pre-clinical models

(This special issue belongs to the Section Molecular Oncology)

Molecular Toxicology of Nano- and Microplastics: Mechanisms of Cellular Disruption and Biochemical Pathways

edited by Ioannis Alexandros Charitos

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1696 | Submission Open

Keywords: nanoplastics; microplastics (NMP); toxicology; toxicological impact; human health; human microbiota; metabolome

(This special issue belongs to the Section Molecular Toxicology)

Recent Research of Nanomaterials in Molecular Science: 3rd Edition

edited by

Giovanna Iezzi

and

Tania Vanessa Pierfelice

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1675 | Submission Open

Keywords: nanomaterials; medical research; synthesis and characterization; molecular formula; molecular dynamics; molecular imaging; cell signaling; cellular metabolism; tissue regeneration; biocompatibility; molecular biology; nanomedicine; functional nanomaterials; drug and gene delivery; tissue engineering; cancer therapy

(This special issue belongs to the Section Molecular Nanoscience)

Epigenetics and RNA Processing Involved in Disease

edited by

Naoyuki Kataoka

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1674 | Submission Open

Keywords: RNA processing; RNA splicing; epigenetics; DNA modification; histone modification; RNA modification; RNA diseases; genetic diseases

(This special issue belongs to the Section Molecular Genetics and Genomics)

Antioxidant and Antidiabetic Potential of Natural Products in the Management of Diabetes and Its Complications

edited by

Ochuko Lucky Erukainure

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1641 | Submission Open

Keywords: diabetes; natural products; obesity; medicinal plants; oxidative stress; antioxidants

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Diagnostics and Therapeutics of Neurodegenerative Disease

edited by

Romina Combi

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1637 | Submission Open

Keywords: neurodegenerative disorders; biomarkers; diagnosis; therapy

(This special issue belongs to the Section Molecular Neurobiology)

The Role of Selenium in Human Health and Disease

edited by

Youcef M. Rustum

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1633 | Submission Open

Keywords: selenium; oxidative stress; immune modulation; cancer prevention and therapy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Synthesis and Molecular Applications of Nanomaterials

edited by

Fernando J. Pereira

A. Javier Aller

and

Roberto Lopez

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1621 | Submission Open

Keywords: nanomaterials; synthesis; molecular applications

(This special issue belongs to the Section Molecular Nanoscience)

Advances in Alzheimer’s Disease: From Metabolic Dysregulation to Molecular Pathophysiology and Therapeutics

edited by Pedro Cisternas

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1594 | Submission Open

Keywords: Alzheimer’s disease; metabolic dysregulation; brain insulin resistance; neuroenergetics; mitochondrial dysfunction; adipokines; neuroinflammation; gut–brain axis; multi-omics biomarkers; therapeutics and precision medicine

(This special issue belongs to the Section Molecular Neurobiology)

Marine Fungi: From Molecular Biology to Biotechnology Application

edited by

Guang-Lei Liu

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1587 | Submission Open

Keywords: marine fungi; marine yeasts; marine filamentous fungi; biosynthesis; metabolic engineering; regulatory mechanism; functional biomolecules; exopolysaccharides; glycolipids; organic acids; biofuel; enzymes; cell factories; gene editing tools; fermentation optimization

(This special issue belongs to the Section Molecular Microbiology)

Training Immunity and Reprogramming Monocytes and Macrophages in Health and Disease

edited by Eugenio A. Carrera Silva

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1586 | Submission Open

Keywords: monocytes; macrophage plasticity; regulatory reprogramming; chronic inflammation

(This special issue belongs to the Section Molecular Immunology)

Sigma-1 Receptor: Signaling, Functions and Therapeutic Potential

edited by Gabriela Cristina Brailoiu and Eugen Brailoiu

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1545 | Submission Open

Keywords: Sigma-1R; intracellular receptor; molecular mechanisms; calcium signaling; neurological diseases; neurodegenerative diseases; pain; cancer; addiction

(This special issue belongs to the Section Molecular Biology)

Sex Differences in Preclinical and Clinical Studies

edited by

Flavia Franconi

Valeria Raparelli

and

Ilaria Campesi

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1542 | Submission Open

Keywords: cellular and in vitro studies; genetic and epigenetic studies; intersectional studies; observational studies; pharmacological studies; pragmatic studies; randomized control trials; disease management

(This special issue belongs to the Section Molecular Biology)

Molecular Strategies for the Discovery, Optimization, and Efficient Use of Green Pesticides

edited by

Hongjian Song

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1536 | Submission Open

Keywords: natural-product-based pesticides; total synthesis; structural optimization; bioactivity evaluation; structure–activity relationship

(This special issue belongs to the Section Molecular Pharmacology)

Roles and Mechanisms of Non-Coding RNAs in Cancer

edited by Stefano Sechi and Daniela Scarabino

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1506 | Submission Open

Keywords: cancer; non-coding RNA (ncRNA); translational medicine; oncological therapy; biomarker; piRNA; lncRNA; circRNA

(This special issue belongs to the Section Molecular Genetics and Genomics)

Gastrointestinal Diseases and Pharmacology

edited by

Giuseppe Esposito

and Irene Palenca

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1505 | Submission Open

Keywords: gastrointestinal diseases; gastrointestinal pharmacology; inflammatory bowel diseases; gastrointestinal cancer; irritable bowel syndrome; visceral hypersensitivity; enteric nervous system; gut–brain axis; intestinal motility; neurogastroenterology; drug discovery; gastrointestinal inflammation; translational pharmacology; therapeutic targets; microbiota–drug interactions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Product-Based Therapeutics: Molecular Mechanisms and Cellular Modulation

edited by Mario Garcia-Dominguez

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1485 | Submission Open

Keywords: natural products; molecular mechanisms; cellular modulation; molecular targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Environmental and Human Adverse Effects of Micro and Nanoplastics: 2nd Edition

edited by

Elena Niccolai

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1467 | Submission Open

Keywords: micro and nanoplastics; environmental pollution; micro and nanoplastic toxicity; human health

(This special issue belongs to the Section Molecular Toxicology)

New Advances in Cardio-Oncology: Mechanisms, Biomarkers, and Therapeutic Strategies

edited by Valentina Citi

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1450 | Submission Open

Keywords: cardio-oncology; cardiotoxicity; cancer therapies; cardiovascular complications; risk stratification; biomarkers; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Recent Advances in Natural Compounds: Biosynthesis and Application

edited by

Abdellah Zinedine

, Marya Raji and El Habib Ait Addi

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1444 | Submission Open

Keywords: natural compounds; chemical composition; biological activities; biosynthesis; bioconversion; application

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Metabolic Signaling and Inflammation in Cardiac Pathophysiology

edited by

Maria Luisa Barcena

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1437 | Submission Open

Keywords: cardiac metabolism; inflammation; metabolic signaling; heart disease; therapeutic targets

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Application of Pulsed Electric Fields in Cancer Therapy

edited by Siqi Guo

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1436 | Submission Open

Keywords: pulsed electric fields; cancer therapy; ablation; minimally invasive; tumor microenvironment; combination therapy

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 251-300 on page 6 of 63.

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