The Role of Selenium in Human Health and Disease

Dear Colleagues,

Selenium (Se), an essential trace element, exerts profound pleiotropic effects on human physiology through its incorporation into selenoprotein, which serves as a key regulator of redox homeostasis, thyroid hormone metabolism, immune modulation, and DNA repair. While optimal Se status is linked to reduced risks of chronic conditions such as cardiovascular disease, neurodegeneration, and certain malignancies, both deficiency and excess manifest in distinct pathologies, including exacerbated oxidative stress. This Special Issue of International Journal of Molecular Sciences aims to elucidate the intricate molecular underpinnings of Se's dual role in health and disease, bridging nutritional science, immunology, and clinical translational research. We invite original research articles, reviews, and perspectives exploring preclinical and clinical insights into Se supplementation for cancer chemoprevention viral immunity (e.g., against SARS-CoV-2), immune modulation of targets associated with drug response and toxicity, and the potential for mechanism-based combination for cancer. We anticipate a collection that not only advances fundamental knowledge but also translates into actionable interventions for public health. By synthesizing multidisciplinary research, this issue seeks to inspire expanded research and clinical development of novel seleno-compounds for precision medicine.

Prof. Dr. Youcef M. Rustum
Guest Editor

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