The Role of Selenium in Human Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: 20 March 2026 | Viewed by 14
Special Issue Editor
Interests: HIFs; TGF-b; oncogenic microRNA-210 druggable targets; mechanism-based biologic and cytotoxic therapies; COVID-19 and selenium
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Selenium (Se), an essential trace element, exerts profound pleiotropic effects on human physiology through its incorporation into selenoprotein, which serves as a key regulator of redox homeostasis, thyroid hormone metabolism, immune modulation, and DNA repair. While optimal Se status is linked to reduced risks of chronic conditions such as cardiovascular disease, neurodegeneration, and certain malignancies, both deficiency and excess manifest in distinct pathologies, including exacerbated oxidative stress. This Special Issue of International Journal of Molecular Sciences aims to elucidate the intricate molecular underpinnings of Se's dual role in health and disease, bridging nutritional science, immunology, and clinical translational research. We invite original research articles, reviews, and perspectives exploring preclinical and clinical insights into Se supplementation for cancer chemoprevention viral immunity (e.g., against SARS-CoV-2), immune modulation of targets associated with drug response and toxicity, and the potential for mechanism-based combination for cancer. We anticipate a collection that not only advances fundamental knowledge but also translates into actionable interventions for public health. By synthesizing multidisciplinary research, this issue seeks to inspire expanded research and clinical development of novel seleno-compounds for precision medicine.
Prof. Dr. Youcef M. Rustum
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- selenium
- oxidative stress
- immune modulation
- cancer prevention and therapy
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
