Recent Advances in Herpesviruses (2nd Edition)
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 91
Special Issue Editor
Interests: virology; herpesvirus and cell hots interaction; herpesviruses associated diseases; viruses
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
α-β-γ-Herpesviridae belong to the Herpesviridae family. They share the same structure and cycle properties. Herpesviruses are organized in icosahedral capsids that surround DNA-stranded genomic DNA. Usually, a viral genome is an episomal structure during the non-productive cycle. Herpesviruses, in fact, have two cycle steps: they show a latent phase, without productive virions, and a lytic phase, with the release of mature virions. The lytic phase can be induced by several stimuli in vitro and in vivo. The acute infection persists in in vivo models in oropharyngeal epithelium without a release of productive virions. The lytic state is characterized by the expression of specific genes. The lytic proteins are necessary to organize the viral DNA in concatenameric structures and to form the mature capsids. The nucleocapsids are released from the nucleus to the cytosol compartements by a proposed specific model. The nuclear membrane leafts are necessary to organize the nuclear complex to induce the release and translocate the nuclear capsids into the cytosol. The latent phase is characterized by the expression of viral proteins involved in cellular and viral mechanisms. They regulate cell cycle progression, apoptosis and cellular proliferation.
Many attempts are ongoing to study new therapeutical treatments to the aim to improve the conventional therapy.
Dr. Marisa Granato
Guest Editor
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Keywords
- α-herpesviridae
- β-herpesviridae
- γ-herpesviridae
- herpesviruses associated diseases
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