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Marine Fungi: From Molecular Biology to Biotechnology Application

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 20 March 2026 | Viewed by 620

Special Issue Editor


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Guest Editor
College of Marine Life Sciences, Ocean University of China, Qingdao 266101, China
Interests: marine yeasts; metabolic engineering; regulatory mechanism; exopolysaccharides; microbial glycolipids
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Special Issue Information

Dear Colleagues,

Marine fungi exhibit widespread distribution across various native marine habitats such as seawater, marine sediments, estuaries, algae, marine invertebrates, animals, and mangrove ecosystems. Surprisingly, they have also been identified in exceptionally harsh environments such as deep-sea extremes. Due to their robust adaptation to such extreme conditions, marine fungi are believed to possess diverse capabilities for synthesizing functional biomolecules. These biomolecules encompass a range of valuable discoveries, including fine chemicals, biofuels, enzymes, bioactive compounds, single-cell proteins, and nanoparticles. The applications of these functional biomolecules span multiple industries, including the food, chemical, agricultural, biofuel, and pharmaceutical sectors, highlighting their significant potential for various industrial uses. This open access Special Issue will curate original research and review articles focused on the molecular biology and biotechnological applications of marine fungi. Emphasizing topics such as new strain resources, genetic tool platforms, metabolic regulatory mechanisms, the construction of cell factories, and the application of metabolites within marine fungi, this Special Issue will highlight cutting-edge advancements in this field.

Prof. Dr. Guang-Lei Liu
Guest Editor

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Keywords

  • marine fungi
  • marine yeasts
  • marine filamentous fungi
  • biosynthesis
  • metabolic engineering
  • regulatory mechanism
  • functional biomolecules
  • exopolysaccharides
  • glycolipids
  • organic acids
  • biofuel
  • enzymes
  • cell factories
  • gene editing tools
  • fermentation optimization

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Published Papers (1 paper)

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Research

26 pages, 5836 KB  
Article
Integrative Study of the Life Cycle in the Marine Protist Thraustochytrium aureum ssp. strugatskii
by Alexey V. Doroshkov, Ludmila G. Naumenko, Daniil A. Iukhtanov, Ksenia N. Morozova, Elena V. Kiseleva, Aleksei G. Menzorov and Ulyana S. Zubairova
Int. J. Mol. Sci. 2025, 26(23), 11302; https://doi.org/10.3390/ijms262311302 - 22 Nov 2025
Viewed by 291
Abstract
Thraustochytrium aureum ssp. strugatskii, a marine protist belonging to the class Labyrinthulea, exhibits a complex life cycle characterized by alternating motile and vegetative phases. Using an integrative multimodal microscopy approach, we reconstructed its full developmental cycle and analyzed the coordination between cellular [...] Read more.
Thraustochytrium aureum ssp. strugatskii, a marine protist belonging to the class Labyrinthulea, exhibits a complex life cycle characterized by alternating motile and vegetative phases. Using an integrative multimodal microscopy approach, we reconstructed its full developmental cycle and analyzed the coordination between cellular morphology, subcellular architecture, and population-level behavior. Transmission and scanning electron microscopy, combined with fluorescence and time-lapse imaging, revealed the dynamics of nuclear division, organelle rearrangement, and zoospore formation. Morphometric analysis of serial ultrathin sections demonstrated distinct changes in mitochondrial distribution, Golgi apparatus, and lipid droplet abundance during transitions between stages. We have shown that vegetative cells undergo synchronized karyokinesis coupled with stable nuclear-to-cytoplasmic ratios, leading to the emergence of multinucleate stages prior to zoospore formation. The integration of ultrastructural and dynamic data enabled us to propose a systems-level model linking metabolic state, morphogenesis, and population structure. This model highlights feedback regulation between nutrient availability, biomass accumulation, and developmental synchronization. Our results establish that T. aureum ssp. strugatskii has good potential to serve as a tractable model organism for systems-level studies of protists and provide an initial framework for predictive modeling of its life cycle under controlled conditions. Full article
(This article belongs to the Special Issue Marine Fungi: From Molecular Biology to Biotechnology Application)
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