Molecular Toxicology of Nano- and Microplastics: Mechanisms of Cellular Disruption and Biochemical Pathways

Dear Colleagues,

The widespread presence of nano- and microplastics (NMP) in the environment presents an escalating threat to public health. The toxicological impact of NMP on human health can occur through the disruption of biochemical mechanisms that regulate homeostasis. Specifically, this includes dysregulation of immune functions, the endocrine system, the central and peripheral nervous systems, metabolism, microbiota balance, and the metabolome. Furthermore, scientific evidence indicates a direct involvement of NMPs in oxidative stress and epigenetic modifications. Originating from primary sources (industrial production) or secondary sources (degradation of larger plastics), NMPs are found in air, water, food, and even human tissues. Once internalized, NMPs can cross biological barriers and accumulate in tissues, disrupting essential cellular processes. These disruptions impair cellular function and biochemical reactions, creating conditions that favor chronic diseases and potentially carcinogenic outcomes. Additionally, NMPs can act as carriers for other environmental contaminants, thereby enhancing their toxicity.

We welcome submissions related to the theme of this Special Issue.

Dr. Ioannis Alexandros Charitos
Guest Editor

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