Natural Product-Based Therapeutics: Molecular Mechanisms and Cellular Modulation

Dear Colleagues,

Natural product-based therapeutics have re-emerged as a vital area of biomedical research, offering diverse chemical scaffolds and bioactive molecules with unique pharmacological properties. This Special Issue, “Natural Product-Based Therapeutics: Molecular Mechanisms and Cellular Modulation,” aims to showcase recent advances in the discovery, characterization, and biomedical application of natural compounds derived from plants, marine organisms, microorganisms, and other biological sources.

We invite contributions that explore how natural products interact with specific molecular targets, modulate signaling pathways, and influence cellular processes such as proliferation, apoptosis, inflammation, oxidative stress, and immune regulation. Studies that integrate modern technologies—including proteomics, transcriptomics, metabolomics, computational modeling, and structure–activity relationship (SAR) analyses—are particularly encouraged. We also welcome research addressing therapeutic potential in disease contexts such as cancer, neurodegeneration, metabolic disorders, cardiovascular diseases, and infectious diseases.

This Special Issue will feature original research articles, reviews, and short communications that provide mechanistic insights and highlight translational potential. Studies on formulation strategies, bioavailability enhancement, and synergistic effects with conventional drugs are also relevant. By bringing together interdisciplinary research, this Issue aims to advance the development of safe, effective, and targeted natural product-based therapies for clinical use.

Dr. Mario Garcia-Dominguez
Guest Editor

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